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Exosome Component 2 (EXOSC2)

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RRP4; Rrp4p; hRrp4p; p7; Ribosomal RNA-processing protein 4

Exosome Component 2 (EXOSC2)
CCC H822
HGNC 17097
MGI 2385133
PubMed 9390555
RGD 1306573
UniProt Q13868
Wiki EXOSC2
Mammalian mRNAs contain AU-rich elements (AREs) within their three prime untranslated regions. In yeast, 3-prime-to-5-prime mRNA degradation is mediated by the exosome, a multisubunit particle. EXOSC2 (which is homologous to the yeast Rrp4 protein) is a component of the human exosome.
The protein encoded by this gene is required for a 3-prime to 5-prime exonuclease activity that generates the 3-prime end of the 5.8S rRNA. The yeast protein, as well as its human homolog, is only 1 enzymatic subunit of a multienzyme ribonuclease complex that Mitchell et al. (1997) referred to as the 'exosome.' The human protein is 43% identical to the yeast protein. Expression of the human RRP4 gene in yeast complemented the mutation in the rrp4.1 strain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH822Hu01 Recombinant Exosome Component 2 (EXOSC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH822Hu21 Monoclonal Antibody to Exosome Component 2 (EXOSC2) WB; IHC; ICC; IP.
PAH822Hu01 Polyclonal Antibody to Exosome Component 2 (EXOSC2) WB; IHC; ICC; IP.
Assay Kits SEH822Hu ELISA Kit for Exosome Component 2 (EXOSC2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Exosome Component 2 (EXOSC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Exosome Component 2 (EXOSC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Exosome Component 2 (EXOSC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Exosome Component 2 (EXOSC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exosome Component 2 (EXOSC2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Exosome Component 2 (EXOSC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Exosome Component 2 (EXOSC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Exosome Component 2 (EXOSC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Exosome Component 2 (EXOSC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exosome Component 2 (EXOSC2) ELISA Kit Customized Service Offer
  1. "Sequence of the human abl and bcr genes."Thesis (1994), University of Oklahoma, United States
  2. "The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases."Cell 91:457-466(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The 3' end of yeast 5.8S rRNA is generated by an exonuclease processing mechanism."Genes Dev. 10:502-513(1996) [PubMed] [Europe PMC] [Abstract]
  7. "The yeast exosome and human PM-Scl are related complexes of 3'-->5' exonucleases."Genes Dev. 13:2148-2158(1999) [PubMed] [Europe PMC] [Abstract]
  8. "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs."Cell 107:451-464(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways."RNA 13:1027-1035(2007) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Dis3-like 1: a novel exoribonuclease associated with the human exosome."EMBO J. 29:2358-2367(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Modulation of exosome-mediated mRNA turnover by interaction of GTP-binding protein 1 (GTPBP1) with its target mRNAs."FASEB J. 25:2757-2769(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Reconstitution, activities, and structure of the eukaryotic RNA exosome."Cell 127:1223-1237(2006) [PubMed] [Europe PMC] [Abstract]
  18. ErratumCell 131:188-189(2007)