≡

RAB1A, Member RAS Oncogene Family (RAB1A)

[Edit]

RAB1; YPT1; Ras-related protein Rab-1A; YPT1-related protein

RAB1A, Member RAS Oncogene Family (RAB1A)
CCC J783
HGNC 9758
MGI 97842
PubMed 23770851
RGD 619736
UniProt P62820
Wiki RAB1A
RAB1A encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. RAB1 recruited p115 to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum (ER), where it interacted with a select set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus.RAB1-regulated assembly of functional effector-SNARE complexes defines a conserved molecular mechanism to coordinate recognition between subcellular compartments.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ783Hu01 Recombinant RAB1A, Member RAS Oncogene Family (RAB1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAJ783Hu21 Monoclonal Antibody to RAB1A, Member RAS Oncogene Family (RAB1A) WB; IHC; ICC; IP.
PAJ783Hu01 Polyclonal Antibody to RAB1A, Member RAS Oncogene Family (RAB1A) WB; IHC; ICC; IP.
Assay Kits SCJ783Hu CLIA Kit for RAB1A, Member RAS Oncogene Family (RAB1A) Chemiluminescent immunoassay for Antigen Detection.
SEJ783Hu ELISA Kit for RAB1A, Member RAS Oncogene Family (RAB1A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB1A, Member RAS Oncogene Family (RAB1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB1A, Member RAS Oncogene Family (RAB1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB1A, Member RAS Oncogene Family (RAB1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB1A, Member RAS Oncogene Family (RAB1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB1A, Member RAS Oncogene Family (RAB1A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB1A, Member RAS Oncogene Family (RAB1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB1A, Member RAS Oncogene Family (RAB1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB1A, Member RAS Oncogene Family (RAB1A) Polyclonal Antibody Customized Service Offer
Assay Kits SEJ783Ra ELISA Kit for RAB1A, Member RAS Oncogene Family (RAB1A) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion."J. Biol. Chem. 264:12394-12401(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (NOV-2005) to UniProtKB
  7. "Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2."Nature 350:715-718(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A."Proc. Natl. Acad. Sci. U.S.A. 91:11963-11967(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Rab GTPases as coordinators of vesicle traffic."Nat. Rev. Mol. Cell Biol. 10:513-525(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Rab1 small GTP-binding protein regulates cell surface trafficking of the human calcium-sensing receptor."Endocrinology 151:5114-5123(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Regulation of integrin beta 1 recycling to lipid rafts by Rab1a to promote cell migration."J. Biol. Chem. 285:29398-29405(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Proteomic analysis of endocytic vesicles: Rab1a regulates motility of early endocytic vesicles."J. Cell Sci. 124:765-775(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Modulation of Rab GTPase function by a protein phosphocholine transferase."Nature 477:103-106(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Legionella pneumophila regulates the small GTPase Rab1 activity by reversible phosphorylcholination."Proc. Natl. Acad. Sci. U.S.A. 108:21212-21217(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  18. "Rab1a and Rab5a preferentially bind to binary lipid compositions with higher stored curvature elastic energy."Mol. Membr. Biol. 30:303-314(2013) [PubMed] [Europe PMC] [Abstract]
  19. "Crystal structure of human RAB1A in complex with GDP."Submitted (FEB-2009) to the PDB data bank
  20. "Structural insights into the dual nucleotide exchange and GDI displacement activity of SidM/DrrA."EMBO J. 29:496-504(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA."Proc. Natl. Acad. Sci. U.S.A. 107:4699-4704(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses."Cell 150:1029-1041(2012) [PubMed] [Europe PMC] [Abstract]
  23. "Structural insights into a unique Legionella pneumophila effector LidA recognizing both GDP and GTP bound Rab1 in their active state."PLoS Pathog. 8:E1002528-E1002528(2012) [PubMed] [Europe PMC] [Abstract]
  24. "Structural analyses of Legionella LepB reveal a new GAP fold that catalytically mimics eukaryotic RasGAP."Cell Res. 23:775-787(2013) [PubMed] [Europe PMC] [Abstract]
  25. "The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism."J. Biol. Chem. 288:24000-24011(2013) [PubMed] [Europe PMC] [Abstract]