V-Ral Simian Leukemia Viral Oncogene Homolog A (RALA)

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RAL; RAS-Like Protein A; Ras-Related Protein Ral-A; Ras Family Small GTP Binding Protein RALA

V-Ral Simian Leukemia Viral Oncogene Homolog A (RALA)
RALA belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins.
Cancer-associated A-beta mutants failed to reverse this tumorigenic phenotype, indicating that the mutants functioned as null alleles. Cancer-derived A-beta mutants failed to form a complex with the small GTPase RALA, whereas wildtype A-beta-containing complexes dephosphorylated RALA at ser183 and ser194, inactivating RALA and abolishing its transforming function.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM097Hu01 Recombinant V-Ral Simian Leukemia Viral Oncogene Homolog A (RALA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM097Hu01 Polyclonal Antibody to V-Ral Simian Leukemia Viral Oncogene Homolog A (RALA) WB; IHC; ICC; IP.
LAM097Hu71 Biotin-Linked Polyclonal Antibody to V-Ral Simian Leukemia Viral Oncogene Homolog A (RALA) WB; IHC; ICC.
MAM097Hu21 Monoclonal Antibody to V-Ral Simian Leukemia Viral Oncogene Homolog A (RALA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for V-Ral Simian Leukemia Viral Oncogene Homolog A (RALA) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Ral Simian Leukemia Viral Oncogene Homolog A (RALA) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant V-Ral Simian Leukemia Viral Oncogene Homolog A (RALA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to V-Ral Simian Leukemia Viral Oncogene Homolog A (RALA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Ral Simian Leukemia Viral Oncogene Homolog A (RALA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for V-Ral Simian Leukemia Viral Oncogene Homolog A (RALA) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Ral Simian Leukemia Viral Oncogene Homolog A (RALA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant V-Ral Simian Leukemia Viral Oncogene Homolog A (RALA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to V-Ral Simian Leukemia Viral Oncogene Homolog A (RALA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Ral Simian Leukemia Viral Oncogene Homolog A (RALA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for V-Ral Simian Leukemia Viral Oncogene Homolog A (RALA) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Ral Simian Leukemia Viral Oncogene Homolog A (RALA) ELISA Kit Customized Service Offer
  1. "Coding sequences of human ralA and ralB cDNAs."Nucleic Acids Res. 17:4380-4380(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of the ral and rac1 gene products, low molecular mass GTP-binding proteins from human platelets."J. Biol. Chem. 264:16383-16389(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA."J. Biol. Chem. 266:9786-9794(1991) [PubMed] [Europe PMC] [Abstract]
  7. "Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity."J. Biol. Chem. 270:22473-22477(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral."J. Biol. Chem. 275:13406-13410(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Ral GTPases regulate exocyst assembly through dual subunit interactions."J. Biol. Chem. 278:51743-51748(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth."Mol. Cell. Biol. 27:8003-8014(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs."EMBO J. 27:2375-2387(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK."Cell. Signal. 21:1207-1217(2009) [PubMed] [Europe PMC] [Abstract]
  13. "RalA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling."Curr. Biol. 20:75-79(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase."EMBO J. 24:2064-2074(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Crystal structure of the C3bot-RalA complex reveals a novel type of action of a bacterial exoenzyme."EMBO J. 24:3670-3680(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Molecular recognition of an ADP-ribosylating Clostridium botulinum C3 exoenzyme by RalA GTPase."Proc. Natl. Acad. Sci. U.S.A. 102:5357-5362(2005) [PubMed] [Europe PMC] [Abstract]