MOCO Sulphurase C-Terminal Domain Containing Protein 1 (MOSC1)

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Molybdenum Cofactor Sulphurase C-Terminal Domain Containing Protein; Mitochondrial amidoxime-reducing component 1

MOCO Sulphurase C-Terminal Domain Containing Protein 1 (MOSC1)
MOSC1 has been reported to reduce amidoximes to amidines. These MOSC domains contain an absolutely conserved cysteine and occur either as stand-alone forms such as the bacterial YiiM proteins, or fused to other domains such as a NifS-like catalytic domain in Molybdenum cofactor sulfurase. The MOSC domain is predicted to be a sulfur-carrier domain that receives sulfur abstracted by the pyridoxal phosphate-dependent NifS-like enzymes, on its conserved cysteine, and delivers it for the formation of diverse sulfur-metal clusters. The identification of this domain may clarify the mechanism of biogenesis of various metallo-enzymes including Molybdenum cofactor-containing enzymes that are compromised in human type II xanthinuria.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR574Hu01 Recombinant MOCO Sulphurase C-Terminal Domain Containing Protein 1 (MOSC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAR574Hu01 Polyclonal Antibody to MOCO Sulphurase C-Terminal Domain Containing Protein 1 (MOSC1) WB,IHC,ICC/IF
MAR574Hu21 Monoclonal Antibody to MOCO Sulphurase C-Terminal Domain Containing Protein 1 (MOSC1) WB; IHC; ICC; IP.
Assay Kits SER574Hu ELISA Kit for MOCO Sulphurase C-Terminal Domain Containing Protein 1 (MOSC1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MOCO Sulphurase C-Terminal Domain Containing Protein 1 (MOSC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MOCO Sulphurase C-Terminal Domain Containing Protein 1 (MOSC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MOCO Sulphurase C-Terminal Domain Containing Protein 1 (MOSC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MOCO Sulphurase C-Terminal Domain Containing Protein 1 (MOSC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for MOCO Sulphurase C-Terminal Domain Containing Protein 1 (MOSC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MOCO Sulphurase C-Terminal Domain Containing Protein 1 (MOSC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MOCO Sulphurase C-Terminal Domain Containing Protein 1 (MOSC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MOCO Sulphurase C-Terminal Domain Containing Protein 1 (MOSC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MOCO Sulphurase C-Terminal Domain Containing Protein 1 (MOSC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for MOCO Sulphurase C-Terminal Domain Containing Protein 1 (MOSC1) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs."J. Med. Chem. 51:8173-8177(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Reduction of N(omega)-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC)."Biochem. J. 433:383-391(2011) [PubMed] [Europe PMC] [Abstract]
  7. "The mitochondrial amidoxime-reducing component (mARC1) is a novel signal-anchored protein of the outer mitochondrial membrane."J. Biol. Chem. 287:42795-42803(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Functional characterization of protein variants encoded by non-synonymous SNPs in MARC1 and MARC2 in healthy Caucasians."Drug Metab. Dispos. 42:718-725(2014) [PubMed] [Europe PMC] [Abstract]