IFNs Antibodies of Cloud-Clone
IFNs are a family of cytokines that are grouped into three types: I, II, and III. In humans, all 17 type I IFNs bind to and signal through a shared heterodimeric receptor complex composed of a single chain of IFNAR1 and IFNAR2, and these are present on nearly all nucleated cells. In contrast to the many type I IFNs, there is only a single type II IFN, IFN-γ, which is produced mainly by immune cells. The impact of type II IFN on shaping the adaptive immune response during viral, bacterial, fungal, and parasitic infections is broad and complex。The type III IFNs (also known as IFN-λs). Type III IFNs signal through a heterodimeric receptor complex including single chains of IL-10R2 and IFNLR1. Consequentially, many cell types respond either very poorly, or not at all, to type III IFNs. Once IFNs bind to their cognate receptor on the cell surface, a signal is propagated within the cell via the JAK‒STAT signaling pathway.They have various functions in the regulation of innate and adaptive immune responses, the response to bacterial ligands, inflflammasome activation, intestinal homeostasis and inflflammatory and autoimmune diseases.