Top-Ranked ELISA Kits (Brain Derived Neurotrophic Factor). Vol.14
Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor that usually exists as dimers in vivo. Mature monomeric BDNF is a 119 amino acid secretory protein with a predicted molecular mass of approximately 3.5 kD and an isoelectric point of 9.99. The secondary structure of mature monomeric BDNF consists of multiple β-sheets and coiled coils, and three disulfide bonds. BDNF is expressed in multiple tissues including central and peripheral nervous system, endocrine system, bone and cartilage tissue. Predominantly, BDNF is expressed in the central nervous system, with the highest level detected in the hippocampus and cortex. Interactions between BDNF and the Trk family receptors (TrkA, TrkB, TrkC), or the neurotrophin receptor (P75 neurotrophin receptor) has been widely studied in neurological researches.