Top-Ranked ELISA Kits (S100 Calcium Binding Protein B). Vol.16
The S100B protein is an acidic calcium binding protein with a molecular weight of 21 kD and is a member of the S100 protein family. Structurally, S100B contains two EF chiral calcium binding regions and auxiliary Zn2+ binding sites. By binding Zn2+to histidine residues in binding sites, the structure of S100B can be changed, and the distance between calcium binding sites can be shortened to play a role as a calcium sensor protein. S100B mainly acts as intracellular calcium receptor protein in organisms. Low concentration of S100B has neurotrophic effect. Glial cells can paracrine and autocrine S100B to promote nerve growth and repair. High concentration of S100B has neurotoxicity and induces neuronal death through NO-dependent pathway in vitro. Therefore, the change of serum content of S100B has an important relationship with nerve damage and pathological changes such as blood-brain barrier and brain injury, and it is often regarded as one of the important indicators for the diagnosis and treatment of neurological diseases.