Granzyme M (GZMM)

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GZM-M; LMET1; MET1; Hu-Met-1; Met-ase; Lymphocyte Met Ase 1; Met-1 serine protease; Natural killer cell granular protease

Granzyme M (GZMM)
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and Met-ase, also known as granzyme M.
By fluorescence in situ hybridization, Pilat et al. (1994) mapped the GZMM gene to chromosome 19p13.3. Interphase studies with 2 differentially labeled probes for GZMM and the azurocidin (AZU1), proteinase-3 (PRTN3), and elastase-2 (ELA2) gene cluster indicated that the GZMM gene is 200 to 500 kb from that gene cluster.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA431Hu01 Recombinant Granzyme M (GZMM) Positive Control; Immunogen; SDS-PAGE; WB.
APA431Hu01 Active Granzyme M (GZMM) Cell culture; Activity Assays.
Antibodies PAA431Hu01 Polyclonal Antibody to Granzyme M (GZMM) WB; IHC
MAA431Hu22 Monoclonal Antibody to Granzyme M (GZMM) WB,IHC
LAA431Hu71 Biotin-Linked Polyclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC.
LAA431Hu81 FITC-Linked Polyclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IF.
MAA431Hu23 Monoclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IP.
Assay Kits SEA431Hu ELISA Kit for Granzyme M (GZMM) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA431Mu01 Recombinant Granzyme M (GZMM) Positive Control; Immunogen; SDS-PAGE; WB.
RPA431Mu02 Recombinant Granzyme M (GZMM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA431Mu01 Polyclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IP.
PAA431Mu02 Polyclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IP.
Assay Kits SEA431Mu ELISA Kit for Granzyme M (GZMM) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA431Ra01 Recombinant Granzyme M (GZMM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA431Ra01 Polyclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Granzyme M (GZMM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Granzyme M (GZMM) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA431Po01 Recombinant Granzyme M (GZMM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA431Po01 Polyclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Granzyme M (GZMM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Granzyme M (GZMM) ELISA Kit Customized Service Offer
  1. "Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells."J. Immunol. 151:6195-6205(1993) [PubMed] [Europe PMC] [Abstract]
  2. "The human Met-ase gene (GZMM): structure, sequence, and close physical linkage to the serine protease gene cluster on 19p13.3."Genomics 24:445-450(1994) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network."J. Immunol. 180:8184-8191(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells."J. Biol. Chem. 285:18326-18335(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M."J. Immunol. 183:421-429(2009) [PubMed] [Europe PMC] [Abstract]