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Peroxisome Proliferator Activated Receptor Gamma (PPARg)

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PPAR-G; PPARG1; PPARG2; NR1C3; Glitazone Receptor; Nuclear Receptor Subfamily 1 Group C Member 3

Peroxisome Proliferator Activated Receptor Gamma (PPARg)
CCC A886
HGNC 9236
MGI 97747
PubMed 18707223
RGD 3371
UniProt P37231
Wiki PPARG

Peroxisome Proliferator-Activated Receptor gamma is a member of the orphan nuclear receptor family. Oxidized metabolites of linoleic acid, 9-hydroxyctadienoic acid (9-HODE) and 13-HODE are activators and ligands of PPAR-gamma. PPAR-gamma; is expressed in white adipose tissue, intestinal mucosa, colon, spleen, monocytes, macrophages, retina, cartilage, osteoclasts, and skeletal muscle. PPAR-γ plays important roles in lipid and glucose metabolism, and has been implicated in obesity-related metabolic diseases such as hyperlipidemia, insulin resistance, and coronary artery disease. Three known family members are called PPAR alpha, delta, and gamma. Three N-terminal isoforms, called gamma1, gamma 2 and gamma 3, are known to arise by alternative splicing and promoter usage from the PPAR-gamma gene. RXR is an obligate partner for PPAR.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA886Hu01 Recombinant Peroxisome Proliferator Activated Receptor Gamma (PPARg) Positive Control; Immunogen; SDS-PAGE; WB.
RPA886Hu02 Recombinant Peroxisome Proliferator Activated Receptor Gamma (PPARg) Positive Control; Immunogen; SDS-PAGE; WB.
APA886Hu01 Active Peroxisome Proliferator Activated Receptor Gamma (PPARg) Cell culture; Activity Assays.
Antibodies PAA886Hu01 Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (PPARg) WB; IHC
MAA886Hu22 Monoclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (PPARg) WB; IHC; ICC; IP.
PAA886Hu02 Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (PPARg) WB; IHC; ICC; IP.
LAA886Hu71 Biotin-Linked Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (PPARg) WB; IHC; ICC.
Assay Kits SEA886Hu ELISA Kit for Peroxisome Proliferator Activated Receptor Gamma (PPARg) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA886Mu01 Recombinant Peroxisome Proliferator Activated Receptor Gamma (PPARg) Positive Control; Immunogen; SDS-PAGE; WB.
RPA886Mu02 Recombinant Peroxisome Proliferator Activated Receptor Gamma (PPARg) Positive Control; Immunogen; SDS-PAGE; WB.
RPA886Mu03 Recombinant Peroxisome Proliferator Activated Receptor Gamma (PPARg) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA886Mu01 Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (PPARg) WB
PAA886Mu02 Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (PPARg) WB; ICC/IF
LAA886Mu71 Biotin-Linked Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (PPARg) WB; IHC; ICC.
PAA886Mu03 Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (PPARg) WB; IHC; ICC; IP.
Assay Kits SEA886Mu ELISA Kit for Peroxisome Proliferator Activated Receptor Gamma (PPARg) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA886Ra01 Recombinant Peroxisome Proliferator Activated Receptor Gamma (PPARg) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA886Ra01 Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (PPARg) WB
MAA886Ra21 Monoclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (PPARg) IHC
MAA886Ra22 Monoclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (PPARg) IHC
MAA886Ra23 Monoclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (PPARg) IHC
MAA886Ra24 Monoclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (PPARg) IHC
MAA886Ra25 Monoclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (PPARg) IHC
Assay Kits SEA886Ra ELISA Kit for Peroxisome Proliferator Activated Receptor Gamma (PPARg) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA886Rb01 Recombinant Peroxisome Proliferator Activated Receptor Gamma (PPARg) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA886Rb51 Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (PPARg) WB; IHC
MAA886Rb21 Monoclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (PPARg) WB; IHC; ICC; IP.
PAA886Rb01 Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (PPARg) WB; IHC; ICC; IP.
Assay Kits SEA886Rb ELISA Kit for Peroxisome Proliferator Activated Receptor Gamma (PPARg) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA886Bo01 Recombinant Peroxisome Proliferator Activated Receptor Gamma (PPARg) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA886Bo01 Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (PPARg) WB; IHC; ICC; IP.
MAA886Bo21 Monoclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (PPARg) WB; IHC; ICC; IP.
Assay Kits SEA886Bo ELISA Kit for Peroxisome Proliferator Activated Receptor Gamma (PPARg) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and activation with retinoid X receptor agonists and antagonists."J. Biol. Chem. 272:8071-8076(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2."Biochem. Biophys. Res. Commun. 224:431-437(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Differential expression of PPAR gamma1 and gamma2 isoforms in human adipose tissue."Biochem. Biophys. Res. Commun. 233:320-324(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping."Gene Expr. 4:281-299(1995) [PubMed] [Europe PMC] [Abstract]
  5. "No coding mutations are detected in the peroxisome proliferator-activated receptor-gamma gene in Japanese patients with lipoatrophic diabetes."Diabetes 46:1904-1906(1997) [PubMed] [Europe PMC] [Abstract]
  6. "A human peroxisome-proliferator-activated receptor-gamma is activated by inducers of adipogenesis, including thiazolidinedione drugs."Eur. J. Biochem. 239:1-7(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of a truncated alternative splicing variant of human PPARgamma1 that exhibits dominant negative activity."Biochem. Biophys. Res. Commun. 347:698-706(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Cloning and characterization of RAP250, a nuclear receptor coactivator."J. Biol. Chem. 275:5308-5317(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Over-representation of PPARgamma sequence variants in sporadic cases of glioblastoma multiforme: preliminary evidence for common low penetrance modifiers for brain tumour risk in the general population."J. Med. Genet. 37:410-414(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha."J. Biol. Chem. 277:28624-28630(2002) [PubMed] [Europe PMC] [Abstract]
  14. "ERAP140, a conserved tissue-specific nuclear receptor coactivator."Mol. Cell. Biol. 22:3358-3372(2002) [PubMed] [Europe PMC] [Abstract]
  15. "ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor."Biochem. Biophys. Res. Commun. 317:54-59(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Hic-5 regulates an epithelial program mediated by PPARgamma."Genes Dev. 19:362-375(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the DNA-binding domain of peroxisome proliferator-activated receptor gamma."Endocrinology 147:377-388(2006) [PubMed] [Europe PMC] [Abstract]
  18. "3-phosphoinositide-dependent protein kinase-1 activates the peroxisome proliferator-activated receptor-gamma and promotes adipocyte differentiation."Mol. Endocrinol. 20:268-278(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Interaction with MEK causes nuclear export and downregulation of peroxisome proliferator-activated receptor gamma."Mol. Cell. Biol. 27:803-817(2007) [PubMed] [Europe PMC] [Abstract]
  20. "Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma."J. Biol. Chem. 285:35330-35339(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator-activated receptor {gamma}."J. Biol. Chem. 286:1354-1363(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Familial focal segmental glomerulosclerosis (FSGS)-linked alpha-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors."J. Biol. Chem. 287:12027-12035(2012) [PubMed] [Europe PMC] [Abstract]
  23. "THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation."Mol. Endocrinol. 27:769-780(2013) [PubMed] [Europe PMC] [Abstract]
  24. "Crystal structure of the ligand binding domain of the human nuclear receptor PPARgamma."J. Biol. Chem. 273:31108-31112(1998) [PubMed] [Europe PMC] [Abstract]
  25. "Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma."Nature 395:137-143(1998) [PubMed] [Europe PMC] [Abstract]
  26. "Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors."Mol. Cell 5:545-555(2000) [PubMed] [Europe PMC] [Abstract]
  27. "Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors."Proc. Natl. Acad. Sci. U.S.A. 98:13919-13924(2001) [PubMed] [Europe PMC] [Abstract]
  28. "Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family."Structure 9:699-706(2001) [PubMed] [Europe PMC] [Abstract]
  29. "Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar."J. Med. Chem. 46:1306-1317(2003) [PubMed] [Europe PMC] [Abstract]
  30. "A new class of peroxisome proliferator-activated receptor agonists with a novel binding epitope shows antidiabetic effects."J. Biol. Chem. 279:41124-41130(2004) [PubMed] [Europe PMC] [Abstract]
  31. "Structure-based design of potent retinoid X receptor alpha agonists."J. Med. Chem. 47:2010-2029(2004) [PubMed] [Europe PMC] [Abstract]
  32. "Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity."J. Med. Chem. 48:4457-4468(2005) [PubMed] [Europe PMC] [Abstract]
  33. "Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner."Proc. Natl. Acad. Sci. U.S.A. 102:9505-9510(2005) [PubMed] [Europe PMC] [Abstract]
  34. "Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis."Bioorg. Med. Chem. Lett. 16:5659-5663(2006) [PubMed] [Europe PMC] [Abstract]
  35. "Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: design, synthesis, structural biology, and molecular docking studies."J. Med. Chem. 49:1212-1216(2006) [PubMed] [Europe PMC] [Abstract]
  36. "Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities."J. Med. Chem. 49:2703-2712(2006) [PubMed] [Europe PMC] [Abstract]
  37. "Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR-gamma) gene in diabetic Caucasians: identification of a pro12ala PPAR-gamma-2 missense mutation."Biochem. Biophys. Res. Commun. 241:270-274(1997) [PubMed] [Europe PMC] [Abstract]
  38. "Obesity associated with a mutation in a genetic regulator of adipocyte differentiation."N. Engl. J. Med. 339:953-959(1998) [PubMed] [Europe PMC] [Abstract]
  39. "A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity."Nat. Genet. 20:284-287(1998) [PubMed] [Europe PMC] [Abstract]
  40. "Missense variants in the human peroxisome proliferator-activated receptor-gamma2 gene in lean and obese subjects."Eur. J. Endocrinol. 141:90-92(1999) [PubMed] [Europe PMC] [Abstract]
  41. "Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women."J. Clin. Endocrinol. Metab. 84:3708-3712(1999) [PubMed] [Europe PMC] [Abstract]
  42. "Loss-of-function mutations in PPAR-gamma associated with human colon cancer."Mol. Cell 3:799-804(1999) [PubMed] [Europe PMC] [Abstract]
  43. "Dominant negative mutations in human PPAR-gamma associated with severe insulin resistance, diabetes mellitus and hypertension."Nature 402:880-883(1999) [PubMed] [Europe PMC] [Abstract]
  44. "PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy."Diabetes 51:3586-3590(2002) [PubMed] [Europe PMC] [Abstract]
  45. "A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy."J. Clin. Endocrinol. Metab. 87:408-411(2002) [PubMed] [Europe PMC] [Abstract]
  46. "Effect of the peroxisome proliferator activated receptor-gamma gene Pro12Ala variant on body mass index: a meta-analysis."J. Med. Genet. 40:773-780(2003) [PubMed] [Europe PMC] [Abstract]
  47. "Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis."J. Clin. Endocrinol. Metab. 89:4238-4242(2004) [PubMed] [Europe PMC] [Abstract]
  48. "Effects of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala polymorphism on body fat distribution in female Korean subjects."Metabolism 53:1538-1543(2004) [PubMed] [Europe PMC] [Abstract]