Cluster Of Differentiation 58 (CD58)

[Edit]

LFA3; Ag3; Surface glycoprotein LFA-3; Lymphocyte Function Associated Antigen 3

Cluster Of Differentiation 58 (CD58)
  • CD58, also known as lymphocyte function-associated antigen (LFA-3), is a 210 amino acid protein that belongs to the CD2 family of the immunoglobulin superfamily.1 CD58 is widely expressed on hematopoietic and non-hematopoietic human tissue and has been found on leukocytes, erythrocytes, endothelial cells, epithelial cells and fibroblasts of human origin.2 No mouse or rat homolog of CD58 has as of yet been identified. CD58 has only one known ligand, CD2. CD2 is expressed on T cells, NK cells and Dendritic cells. CD2 ligation by CD58 has been shown to mediate T cell adhesion, T cell activation, T cell cytokine production and T cell and NK cells cytotoxic activity. In dendritic cells, CD2 engagement increases MHC Class II, CD40, CD80, CD86, CD58 and CCR7 and induces IL-1beta; IL-12 cytokine secretion.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA903Hu01 Recombinant Cluster Of Differentiation 58 (CD58) Positive Control; Immunogen; SDS-PAGE; WB.
EPA903Hu61 Eukaryotic Cluster Of Differentiation 58 (CD58) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA903Hu01 Polyclonal Antibody to Cluster Of Differentiation 58 (CD58) WB; IHC; ICC; IP.
MAA903Hu22 Monoclonal Antibody to Cluster Of Differentiation 58 (CD58) WB; IHC; ICC; IP.
MAA903Hu21 Monoclonal Antibody to Cluster Of Differentiation 58 (CD58) WB; IHC; ICC; IP.
MAA903Hu23 Monoclonal Antibody to Cluster Of Differentiation 58 (CD58) WB; IHC; ICC; IP.
MAA903Hu24 Monoclonal Antibody to Cluster Of Differentiation 58 (CD58) WB; IHC; ICC; IP.
Assay Kits SEA903Hu ELISA Kit for Cluster Of Differentiation 58 (CD58) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Primary structure of lymphocyte function-associated antigen 3 (LFA-3). The ligand of the T lymphocyte CD2 glycoprotein."J. Exp. Med. 166:923-932(1987) [PubMed] [Europe PMC] [Abstract]
  2. "An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2."Nature 329:840-842(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Gene structure, promoter characterization, and basis for alternative mRNA splicing of the human CD58 gene."J. Immunol. 160:2862-2871(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment."J. Proteome Res. 5:935-943(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors."Cell 97:791-803(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structure of the CD2-binding domain of CD58 (lymphocyte function-associated antigen 3) at 1.8-A resolution."Proc. Natl. Acad. Sci. U.S.A. 96:4289-4294(1999) [PubMed] [Europe PMC] [Abstract]