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Cluster Of Differentiation 97 (CD97)

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TM7LN1; TM7-LN1; Seven-Span Transmembrane Protein; Seven-Transmembrane,Heterodimeric Receptor Associated With Inflammation; Seven Transmembrane Helix Receptor

Cluster Of Differentiation 97 (CD97)
CCC B410
HGNC 1711
MGI 1347095
PubMed 12417446
RGD 1305595
UniProt P48960
Wiki CD97

CD97 antigen is a glycoprotein that is present on the surface of most activated leukocytes and spans the membrane seven times, which is a defining feature of G protein-coupled receptors. The protein has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to its cellular ligand, decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade.

The presence of structural features characteristic of extracellular matrix proteins and transmembrane proteins suggests that this protein is a receptor involved in both cell adhesion and signaling processes early after leukocyte activation. Alternative splicing has been observed for this gene and three variants have been found.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB410Hu01 Recombinant Cluster Of Differentiation 97 (CD97) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAB410Hu21 Monoclonal Antibody to Cluster Of Differentiation 97 (CD97) WB; IHC
MAB410Hu22 Monoclonal Antibody to Cluster Of Differentiation 97 (CD97) IHC
MAB410Hu23 Monoclonal Antibody to Cluster Of Differentiation 97 (CD97) IHC
MAB410Hu24 Monoclonal Antibody to Cluster Of Differentiation 97 (CD97) IHC
PAB410Hu01 Polyclonal Antibody to Cluster Of Differentiation 97 (CD97) WB; IHC; ICC; IP.
MAB410Hu25 Monoclonal Antibody to Cluster Of Differentiation 97 (CD97) ICC/IF
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 97 (CD97) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 97 (CD97) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB410Mu01 Recombinant Cluster Of Differentiation 97 (CD97) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB410Mu01 Polyclonal Antibody to Cluster Of Differentiation 97 (CD97) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 97 (CD97) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 97 (CD97) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB410Ra01 Recombinant Cluster Of Differentiation 97 (CD97) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB410Ra01 Polyclonal Antibody to Cluster Of Differentiation 97 (CD97) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 97 (CD97) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 97 (CD97) ELISA Kit Customized Service Offer
  1. "Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain."J. Immunol. 155:1942-1950(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily."Genomics 32:144-147(1996) [PubMed] [Europe PMC] [Abstract]
  3. "CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation."J. Immunol. 157:5438-5447(1996) [PubMed] [Europe PMC] [Abstract]
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  8. "The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans."Blood 102:2916-2924(2003) [PubMed] [Europe PMC] [Abstract]
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  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
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  13. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]