Matrix Gla Protein (MGP)

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MGLAP; GIG36; Cell growth-inhibiting gene 36 protein

Matrix Gla Protein (MGP)

Matrix gla protein (MGP) is a protein found in numerous body tissues that requires vitamin K for its optimum function. It is present in bone (together with the related vitamin K-dependent protein osteocalcin), as well as in heart, kidney and lung. In bone, its production is increased by vitamin D.

MGP and osteocalcin are both calcium-binding proteins that may participate in the organisation of bone tissue. Both have glutamate residues that are post-translationally carboxylated by the enzyme gamma-glutamyl carboxylase in a reaction that requires Vitamin K hydroquinone. This process also occurs with a number of proteins involved in coagulation: prothrombin, factor VII, factor IX and factor X, protein C, protein S and protein Z.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB477Hu01 Recombinant Matrix Gla Protein (MGP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB477Hu01 Polyclonal Antibody to Matrix Gla Protein (MGP) WB; IHC; ICC; IP.
MAB477Hu22 Monoclonal Antibody to Matrix Gla Protein (MGP) WB
MAB477Hu21 Monoclonal Antibody to Matrix Gla Protein (MGP) WB
MAB477Hu23 Monoclonal Antibody to Matrix Gla Protein (MGP) WB
Assay Kits SEB477Hu ELISA Kit for Matrix Gla Protein (MGP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB477Mu01 Recombinant Matrix Gla Protein (MGP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB477Mu02 Recombinant Matrix Gla Protein (MGP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB477Mu01 Polyclonal Antibody to Matrix Gla Protein (MGP) WB; IHC; ICC; IP.
LAB477Mu71 Biotin-Linked Polyclonal Antibody to Matrix Gla Protein (MGP) WB; IHC; ICC.
PAB477Mu02 Polyclonal Antibody to Matrix Gla Protein (MGP) WB; IHC; ICC; IP.
Assay Kits SEB477Mu ELISA Kit for Matrix Gla Protein (MGP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB477Ra01 Recombinant Matrix Gla Protein (MGP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB477Ra02 Recombinant Matrix Gla Protein (MGP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB477Ra01 Polyclonal Antibody to Matrix Gla Protein (MGP) WB; IHC; ICC; IP.
LAB477Ra71 Biotin-Linked Polyclonal Antibody to Matrix Gla Protein (MGP) WB; IHC; ICC.
LAB477Ra81 FITC-Linked Polyclonal Antibody to Matrix Gla Protein (MGP) WB; IHC; ICC; IF.
PAB477Ra02 Polyclonal Antibody to Matrix Gla Protein (MGP) WB; IHC; ICC; IP.
Assay Kits SEB477Ra ELISA Kit for Matrix Gla Protein (MGP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB477Rb01 Recombinant Matrix Gla Protein (MGP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB477Rb51 Polyclonal Antibody to Matrix Gla Protein (MGP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Matrix Gla Protein (MGP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Matrix Gla Protein (MGP) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB477Po01 Recombinant Matrix Gla Protein (MGP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB477Po01 Polyclonal Antibody to Matrix Gla Protein (MGP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Matrix Gla Protein (MGP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Matrix Gla Protein (MGP) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB477Bo01 Recombinant Matrix Gla Protein (MGP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB477Bo01 Polyclonal Antibody to Matrix Gla Protein (MGP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Matrix Gla Protein (MGP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Matrix Gla Protein (MGP) ELISA Kit Customized Service Offer
  1. "Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene."J. Biol. Chem. 265:15040-15048(1990) [PubMed] [Europe PMC] [Abstract]
  2. "The cDNA and derived amino acid sequences for human and bovine matrix Gla protein."Nucleic Acids Res. 16:5213-5213(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Overexpression of matrix Gla protein mRNA in malignant human breast cells: isolation by differential cDNA hybridization."Oncogene 5:1391-1395(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Conserved phosphorylation of serines in the Ser-X-Glu/Ser(P) sequences of the vitamin K-dependent matrix Gla protein from shark, lamb, rat, cow, and human."Protein Sci. 3:822-830(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Carboxyl-terminal proteolytic processing of matrix Gla protein."J. Biol. Chem. 266:21145-21149(1991) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome."Nat. Genet. 21:142-144(1999) [PubMed] [Europe PMC] [Abstract]