Ribonuclease A3 (RNASE3)

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Rnase-A3; RnaseA3; ECP; RNS3; Ribonuclease,RNase A Family 3; Eosinophil Cationic Protein

Ribonuclease A3 (RNASE3)

Eosinophil cationic protein, like eosinophil-derived neurotoxin, is localized to the granule matrix of the eosinophil. Both proteins possess neurotoxic, helminthotoxic, and ribonucleolytic activities. The cDNA sequences of the genes encoding these 2 proteins and the deduced amino acid sequences indicate that the genes belong to the ribonuclease gene superfamily. Hamann et al. (1990) demonstrated remarkable similarities of eosinophil-derived neurotoxin and eosinophil cationic protein, symbolized RNS2 and RNS3, respectively, in noncoding sequences, introns, and flanking regions, as well as the previously known coding regions. A single intron in the 5-prime untranslated region and an intronless coding region appear to be features common to many members of the RNase gene superfamily.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB758Hu01 Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
RPB758Hu02 Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
RPB758Hu03 Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB758Hu01 Polyclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
MAB758Hu22 Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
MAB758Hu21 Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB
LAB758Hu72 Biotin-Linked Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC.
PAB758Hu02 Polyclonal Antibody to Ribonuclease A3 (RNASE3) WB
MAB758Hu23 Monoclonal Antibody to Ribonuclease A3 (RNASE3) IHC
MAB758Hu24 Monoclonal Antibody to Ribonuclease A3 (RNASE3) IHC
MAB758Hu25 Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
LAB758Hu74 Biotin-Linked Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC.
LAB758Hu76 Biotin-Linked Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC.
Assay Kits SEB758Hu ELISA Kit for Ribonuclease A3 (RNASE3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB758Mu01 Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
RPB758Mu02 Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
RPB758Mu03 Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB758Mu01 Polyclonal Antibody to Ribonuclease A3 (RNASE3) WB
MAB758Mu21 Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
LAB758Mu72 Biotin-Linked Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC.
MAB758Mu22 Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB
Assay Kits SEB758Mu ELISA Kit for Ribonuclease A3 (RNASE3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB758Ra01 Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB758Ra01 Polyclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
MAB758Ra21 Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB
LAB758Ra72 Biotin-Linked Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Ribonuclease A3 (RNASE3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribonuclease A3 (RNASE3) ELISA Kit Customized Service Offer
  1. "Human eosinophil cationic protein. Molecular cloning of a cytotoxin and helminthotoxin with ribonuclease activity."J. Exp. Med. 170:163-176(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily."Genomics 7:535-546(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Eosinophil cationic protein cDNA. Comparison with other toxic cationic proteins and ribonucleases."J. Immunol. 143:952-955(1989) [PubMed] [Europe PMC] [Abstract]
  4. "Sequence variation at two eosinophil-associated ribonuclease loci in humans."Genetics 156:1949-1958(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease."Proc. Natl. Acad. Sci. U.S.A. 83:3146-3150(1986) [PubMed] [Europe PMC] [Abstract]
  8. "Antibiotic proteins of human polymorphonuclear leukocytes."Proc. Natl. Acad. Sci. U.S.A. 86:5610-5614(1989) [PubMed] [Europe PMC] [Abstract]
  9. "Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase." J. Biol. Chem. 283:28629-28640(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Bactericidal and membrane disruption activities of the eosinophil cationic protein are largely retained in an N-terminal fragment."Biochem. J. 421:425-434(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Eosinophil cationic protein aggregation: identification of an N-terminus amyloid prone region."Biomacromolecules 11:1983-1990(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of eosinophil cationic protein at 2.4 A resolution."Biochemistry 38:16794-16801(1999) [PubMed] [Europe PMC] [Abstract]
  13. "Three-dimensional crystal structure of human eosinophil cationic protein (RNase 3) at 1.75 A resolution."J. Mol. Biol. 300:1297-1307(2000) [PubMed] [Europe PMC] [Abstract]
  14. "The crystal structure of eosinophil cationic protein in complex with 2',5'-ADP at 2.0 A resolution reveals the details of the ribonucleolytic active site."Biochemistry 41:12100-12106(2002) [PubMed] [Europe PMC] [Abstract]