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Mitogen Activated Protein Kinase 10 (MAPK10)

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JNK3; SAPK1b; PRKM10; Stress-activated protein kinase 1b; Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3; MAP kinase p49 3F12

Mitogen Activated Protein Kinase 10 (MAPK10)
CCC B869
HGNC 6872
MGI 1346863
PubMed 21166945
RGD 3663
UniProt P53779
Wiki MAPK10

Gupta et al. (1996) isolated brain cDNAs encoding 10 different JNK isoforms, 8 of which were derived from either JNK1  or JNK2 . The other 2 cDNAs were from a gene that the authors designated JNK3. JNK3 contains an extended N-terminal region not found in JNK1 or JNK2. The 2 JNK3 isoforms, called JNK3-alpha-1 and JNK3-alpha-2, have different C termini.

By SDS-PAGE of in vitro transcription/translation products, Gupta et al. (1996) determined that JNK3-alpha-1 migrates as a 45-to-48-kD doublet and JNK3-alpha-2 migrates as a 54-to-57-kD doublet. They stated that the lower band probably represents translation from a second in-frame start codon that corresponds to the first codon in JNK1 and JNK2. All the JNKs were activated by treatment of cells with the inflammatory cytokine IL1 .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB869Hu01 Recombinant Mitogen Activated Protein Kinase 10 (MAPK10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB869Hu01 Polyclonal Antibody to Mitogen Activated Protein Kinase 10 (MAPK10) WB; IHC; ICC; IP.
LAB869Hu71 Biotin-Linked Polyclonal Antibody to Mitogen Activated Protein Kinase 10 (MAPK10) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase 10 (MAPK10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase 10 (MAPK10) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase 10 (MAPK10) Recombinant Protein Customized Service Offer
Antibodies PAB869Mu01 Polyclonal Antibody to Mitogen Activated Protein Kinase 10 (MAPK10) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase 10 (MAPK10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase 10 (MAPK10) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase 10 (MAPK10) Recombinant Protein Customized Service Offer
Antibodies PAB869Ra01 Polyclonal Antibody to Mitogen Activated Protein Kinase 10 (MAPK10) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase 10 (MAPK10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase 10 (MAPK10) ELISA Kit Customized Service Offer
  1. "p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system."Neuron 14:67-78(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Selective interaction of JNK protein kinase isoforms with transcription factors."EMBO J. 15:2760-2770(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1."Biochemistry 39:3141-3148(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7."Biochem. J. 352:145-154(2000) [PubMed] [Europe PMC] [Abstract]
  8. "c-Jun N-terminal kinase-3 (JNK3)/stress-activated protein kinase-beta (SAPKbeta) binds and phosphorylates the neuronal microtubule regulator SCG10."FEBS Lett. 508:259-264(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein."Biochem. J. 389:73-82(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Truncation of the CNS-expressed JNK3 in a patient with a severe developmental epileptic encephalopathy."Hum. Genet. 118:559-567(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Visual and both non-visual arrestins in their 'inactive' conformation bind JNK3 and Mdm2 and relocalize them from the nucleus to the cytoplasm."J. Biol. Chem. 281:21491-21499(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Neuroprotection by histone deacetylase-related protein."Mol. Cell. Biol. 26:3550-3564(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAPKs: implications for beta2-adrenoceptor signalling via the ERK1/2 MAPKs."Biochem. J. 413:51-60(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Isoform-specific palmitoylation of JNK regulates axonal development."Cell Death Differ. 19:553-561(2012) [PubMed] [Europe PMC] [Abstract]
  15. "JNK regulates the photic response of the mammalian circadian clock."EMBO Rep. 13:455-461(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Crystal structure of JNK3: a kinase implicated in neuronal apoptosis."Structure 6:983-991(1998) [PubMed] [Europe PMC] [Abstract]