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Axis Inhibition Protein (AXIN)

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AXIN1

Axis Inhibition Protein (AXIN)
CCC C191
HGNC 903
MGI 1096327
PubMed 23879168
RGD 620859
UniProt O15169
Wiki AXIN1
Axin-1 encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin (cadherin-associated protein), beta 1, 88kDa, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC191Hu01 Recombinant Axis Inhibition Protein (AXIN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC191Hu01 Polyclonal Antibody to Axis Inhibition Protein (AXIN) WB; IHC; ICC; IP.
Assay Kits SEC191Hu ELISA Kit for Axis Inhibition Protein (AXIN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC191Mu01 Recombinant Axis Inhibition Protein (AXIN) Positive Control; Immunogen; SDS-PAGE; WB.
RPC191Mu02 Recombinant Axis Inhibition Protein (AXIN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC191Mu01 Polyclonal Antibody to Axis Inhibition Protein (AXIN) WB; IHC; ICC; IP.
PAC191Mu02 Polyclonal Antibody to Axis Inhibition Protein (AXIN) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Axis Inhibition Protein (AXIN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Axis Inhibition Protein (AXIN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC191Ra01 Recombinant Axis Inhibition Protein (AXIN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC191Ra01 Polyclonal Antibody to Axis Inhibition Protein (AXIN) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Axis Inhibition Protein (AXIN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Axis Inhibition Protein (AXIN) ELISA Kit Customized Service Offer
  1. "The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation."Cell 90:181-192(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain."J. Biol. Chem. 274:3439-3445(1999) [PubMed] [Europe PMC] [Abstract]
  6. "AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1."Nat. Genet. 24:245-250(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway."Mol. Cell 7:801-809(2001) [PubMed] [Europe PMC] [Abstract]
  8. "I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways."Mol. Cell. Biol. 22:6393-6405(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)."EMBO J. 22:3084-3094(2003) [PubMed] [Europe PMC] [Abstract]
  10. "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms."J. Biol. Chem. 279:39366-39373(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Increased DNA methylation at the AXIN1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly."Am. J. Hum. Genet. 79:155-162(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia."EMBO J. 25:1646-1658(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death."Cancer Res. 67:66-74(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex."EMBO J. 26:1511-1521(2007) [PubMed] [Europe PMC] [Abstract]
  15. "SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability."FASEB J. 22:3785-3794(2008) [PubMed] [Europe PMC] [Abstract]
  16. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling." Nature 461:614-620(2009) [PubMed] [Europe PMC] [Abstract]
  18. "The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/beta-catenin signaling."Mol. Cell. Biol. 31:2053-2065(2011) [PubMed] [Europe PMC] [Abstract]
  19. "RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling."Nat. Cell Biol. 13:623-629(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling."PLoS ONE 6:E22595-E22595(2011) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Structural basis of the axin-adenomatous polyposis coli interaction."EMBO J. 19:2270-2279(2000) [PubMed] [Europe PMC] [Abstract]
  23. "Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex."EMBO J. 22:494-501(2003) [PubMed] [Europe PMC] [Abstract]
  24. "Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas."Oncogene 21:4863-4871(2002) [PubMed] [Europe PMC] [Abstract]