Melanoma Inhibitory Activity Protein 1 (MIA1)

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CD-RAP; Melanoma-derived growth regulatory protein

Melanoma Inhibitory Activity Protein 1 (MIA1)
Growth and expansion of tumor cells including malignant melanomas are modulated by a complex network of growth factors, which regulate proliferation and cell-matrix interaction through a variety of different signal transduction pathways.
Bosserhoff et al. (1996) cloned the gene encoding MIA and described its genomic organization. The gene encodes a 131-amino acid prepropolypeptide with a 24-residue secretion signal peptide sequence. The authors identified the transcription start site of the gene and studied the expression characteristics of the gene promoter in human melanoma, epithelial, and undifferentiated cells. Bosserhoff et al. (1996) found by Northern blot analysis that the MIA gene was expressed in all melanoma cell lines tested but was not expressed in fibroblast or epithelial cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH650Hu01 Recombinant Melanoma Inhibitory Activity Protein 1 (MIA1) Positive Control; Immunogen; SDS-PAGE; WB.
APH650Hu01 Active Melanoma Inhibitory Activity Protein 1 (MIA1) Cell culture; Activity Assays.
Antibodies PAH650Hu01 Polyclonal Antibody to Melanoma Inhibitory Activity Protein 1 (MIA1) WB; IHC; ICC; IP.
MAH650Hu21 Monoclonal Antibody to Melanoma Inhibitory Activity Protein 1 (MIA1) WB; IHC; ICC; IP.
Assay Kits SEH650Hu ELISA Kit for Melanoma Inhibitory Activity Protein 1 (MIA1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH650Mu01 Recombinant Melanoma Inhibitory Activity Protein 1 (MIA1) Positive Control; Immunogen; SDS-PAGE; WB.
RPH650Mu02 Recombinant Melanoma Inhibitory Activity Protein 1 (MIA1) Positive Control; Immunogen; SDS-PAGE; WB.
APH650Mu01 Active Melanoma Inhibitory Activity Protein 1 (MIA1) Cell culture; Activity Assays.
Antibodies PAH650Mu01 Polyclonal Antibody to Melanoma Inhibitory Activity Protein 1 (MIA1) WB; IHC; ICC; IP.
PAH650Mu02 Polyclonal Antibody to Melanoma Inhibitory Activity Protein 1 (MIA1) WB; IHC; ICC; IP.
Assay Kits SEH650Mu ELISA Kit for Melanoma Inhibitory Activity Protein 1 (MIA1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH650Ra01 Recombinant Melanoma Inhibitory Activity Protein 1 (MIA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH650Ra01 Polyclonal Antibody to Melanoma Inhibitory Activity Protein 1 (MIA1) WB; IHC; ICC; IP.
MAH650Ra21 Monoclonal Antibody to Melanoma Inhibitory Activity Protein 1 (MIA1) WB; IHC; ICC; IP.
Assay Kits SEH650Ra ELISA Kit for Melanoma Inhibitory Activity Protein 1 (MIA1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA."Cancer Res. 54:5695-5701(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Structure and promoter analysis of the gene encoding the human melanoma-inhibiting protein MIA."J. Biol. Chem. 271:490-495(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and characterization of the expression pattern of a novel splice product MIA (splice) of malignant melanoma-derived growth-inhibiting activity (MIA/CD-RAP)."J. Invest. Dermatol. 119:562-569(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis."Mol. Biol. Cell 23:1646-1656(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins."Proc. Natl. Acad. Sci. U.S.A. 98:5515-5520(2001) [PubMed] [Europe PMC] [Abstract]