Spleen Mononuclear Cells (SpMC)

Spleen Mononuclear Cells (SpMCs), also frequently abbreviated as SpMC, are a heterogeneous group of immune-competent cells residing in the spleen, a pivotal secondary lymphoid organ. This cell population consists of multiple key subtypes involved in both innate and adaptive immune responses, including T lymphocytes, B lymphocytes, natural killer (NK) cells, monocytes, macrophages, and dendritic cells. These cells undertake diverse critical immune functions. For instance, dendritic cells are responsible for antigen presentation, activating downstream adaptive immune reactions; B cells can synthesize antibodies to neutralize pathogens; T cells and NK cells participate in eliminating infected or abnormal cells, and monocytes can differentiate into macrophages to phagocytose foreign substances.