Tracheal Fibroblasts (TrF)

Tracheal fibroblasts are mesenchymal cells found in the connective tissue of the trachea, and they are essential for maintaining the structural integrity and functionality of the trachea. These cells, of mesenchymal origin, play a critical role in extracellular matrix remodeling, wound healing, and inflammatory responses in airway diseases. They are responsible for synthesizing and depositing extracellular matrix (ECM) components, such as collagen, elastin, and fibronectin, which provide structural support and regulate tissue homeostasis. Moreover, fibroblasts orchestrate tissue regeneration by allowing other cells to settle and migrate.

Dysregulation of tracheal fibroblasts contributes to fibrotic disorders (e.g., subglottic stenosis) and chronic airway diseases (e.g., asthma, chronic obstructive pulmonary disease [COPD]). Additionally, in the central nervous system, fibroblasts are present in the meninges, choroid plexus, and perivascular space, contributing to the structural integrity and function of these areas.