Pancreatic Duct Epithelial Cells (PDEC)

Pancreatic Duct Epithelial Cells (PDECs) are specialized epithelial cells lining the pancreatic ductal tree, a key component of the exocrine pancreas. Their core function is secreting bicarbonate-rich fluid (via CFTR channels) and mucins, which neutralize duodenal acidic chyme and shield the ductal epithelium from proteolytic enzyme damage.

Physiologically, PDECs form a tubular network that collects digestive proenzymes from acinar cells and transports them to the duodenum, ensuring proper digestive function. They also maintain ductal integrity and may act as progenitor cells during pancreatic repair after injury.

Pathologically, PDECs are pivotal in pancreatic diseases: they are the primary cell of origin for pancreatic ductal adenocarcinoma (PDAC), the most common pancreatic cancer, often arising from precursor lesions (PanINs) with genetic mutations like KRAS. Dysfunctional secretion or duct obstruction by PDECs also contributes to pancreatitis development.