Peritoneal Macrophage (PM)

Peritoneal macrophages (PMs) are a critical component of the innate immune system residing within the , performing diverse functions in immune surveillance, tissue homeostasis, and inflammatory responses. These highly heterogeneous cells adapt to distinct tissue environments and specialize to develop niche-specific functions. The peritoneal cavity, comprising the peritoneal fluid,  and omentum, provides a unique microenvironment for these macrophages.

PMs exhibit significant phenotypic and functional diversity influenced by their tissue microenvironment, and their roles are crucial in various physiological and pathological conditions, including infection, cancer, and inflammatory diseases. They are involved in phagocytosis, antigen presentation, and cytokine production. For example, PMs can release neutrophil chemotactic factors, a process that can be inhibited by glucocorticoids.