Cytokeratin 17 (CK 17) is a type I Keratin with a relative molecular weight of 46,000, which plays an important role in the formation and maintenance of various skin appendages. CK17 is mainly distributed in the basal cells of sweat glands and deep outer hair root sheath, and is mildly expressed in normal basal cells. Abnormal expression of CK17 occurs when epidermal keratinocytes show abnormal proliferation and differentiation. Several studies have shown that CK17 is abnormally expressed in a variety of skin diseases and cancers, including psoriasis, seborrheic keratosis, cutaneous squamous cell carcinoma, basal cell carcinoma, malignant melanoma, and other epithelial tumors. Therefor......2021-12-20

Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disease that affects the ileum, rectum and colon. Crohn's disease (CD) and ulcerative colitis (UC) are two major forms of IBD.The global distribution of IBD tends to be more prominent in North America and Europe, but its prevalence has increased in developing countries such as China and India over the past 20 years.Potential therapeutic targets for IBDThe etiology and pathogenesis of IBD have not been fully clarified. It is known that the inflammatory response caused by abnormal immune system reaction of intestinal mucosa plays an important role in the pathogenesis of IBD, which is believed to be caused by the in......2021-12-16

On October 21, 2021, Miguel López, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Spain, and his team , published a paper titled "Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation" on Nature Metabolism, which underscored the potential of small extracellular vesicle (sEVs) to specifically target AMPK in hypothalamic neurons.The kits (ELISA Kit for Growth Differentiation Factor 15 (GDF15), SEC034Mu) of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Current pharmacological therapies for treating obesity are of limited efficacy. Genetic ablation......2021-12-14

Cytokeratin 19 (CK19) is mainly distributed in monolayer and pseudostratified epithelial cells, and is overexpressed in various epithelial tumor tissues. CK19 has great value in the diagnosis of lung cancer, especially the current preferred tumor marker for non-small cell lung cancer, with sensitivity up to 60% and specificity up to 95%. In addition, CK19 has a certain positive rate for other tumors, such as head and neck, breast, cervix, bladder and digestive tract tumors. Therefore, CK19 is of great significance for the early diagnosis, curative effect monitoring and prognosis of these cancers.2021-12-13

Tumor immunity is a process of immune response to the occurrence and development of tumors based on tumor antigenicity and immune function of the body.Antitumor immunotherapy is to stimulate and enhance the immune function of the body in order to control and kill tumor cells.Antitumor immunity improves the therapeutic effect of tumorRadiation therapy and chemotherapy are conventional treatments for cancer that have long been in use, but neither of these treatments can completely destroy tumor cells. The last surviving tumor cells need to be taken care of by the body's immune system. Therefore, it is of great significance to explore the mechanism of anti-tumor immunity in improving ......2021-12-10

Arginase (ARG) is an enzyme involved in the urea cycle, which catalyzes the hydrolysis of L-arginine into L-ornithine and urea.The content of ARG in liver isthe highest, followed by kidney, heart, spleen and skeletal muscle.ARG plays an important role in protecting cells from NH3 poisoning and cell growth and repair. In addition, studies have shown that the excessive activity of the ARG/ornithine pathway promotes cardiovascular and renal dysfunction and damage, and plays a role in the progression of central nervous system diseases and cancer. Therefore, ARG detection can help in the diagnosis and treatment of cardiovascular, renal and central nervous system diseases, as well as cancer.2021-12-07