2021-03-16

On 18 February, 2021, professor Marcus S. Cooke from Department of Occupational Safety and Health, Chung Shan Medical University published a paper on Redox Biology. The paper titled Biomarkers of nucleic acid oxidation ‒ A summary state-of-the-art.Oxidatively generated damage to DNA has been implicated in the pathogenesis of a wide variety of diseases. Increasingly, interest is also focusing upon the effffects of damage to the other nucleic acids, RNA and the (2′-deoxy-)ribonucleotide pools, and evidence is growing that these too may have an important role in disease. LC-MS/MS has the ability to provide absolute quantifification of specifific biomarkers, such as 8-oxo-7,8-dihydro......2021-03-15

On 18 February, 2021, professor Robert W.Taylor from Newcastle University and Claes M.Gustafsson from University of Gothenburg published a paper on Nature communications. The paper titled POLRMT mutations impair mitochondrial transcription causing neurological disease.While >300 disease-causing variants have been identifified in the mitochondrial DNA (mtDNA) polymerase γ, no mitochondrial phenotypes have been associated with POLRMT, the RNA polymerase responsible for transcription of the mitochondrial genome. Here, we characterise the clinical and molecular nature of POLRMT variants in eight individuals from seven unrelated families. Patients present with global developmental delay......2021-03-08

On 29 January, 2021, professor Lee A Denson from Cincinnati Children’s Hospital Medical Center，Syed Asad Ali from Aga Khan University and Sean R Moore from University of Virginia published a paper on Gastroenterology. The paper titled Mucosal Genomics Implicate Lymphocyte Activation and Lipid Metabolism in Refractory Environmental Enteric Dysfunction.Background & Aims: Environmental enteric dysfunction (EED) limits the Sustainable Development Goals of improved childhood growth and survival. We applied mucosal genomics to advance our understanding of EED.Methods: The Study of Environmental Enteropathy and Malnutrition (SEEM) followed 416 children from birth to 24 months in a rural d......2021-03-02

In Feb. 2021, Literature of Cloud Clone products has exceeded 230. Cloud-Clone could provide multipleproteins, antibodies and ELISA kit, which has been praised by customers.2021-02-26

On 31 December, 2020, professor Kyoungho Suk from Kyungpook National University published a paper on Brain. The paper titled Gamma subunit of complement component 8 is a neuroinflflammation inhibitor.The complement system is part of the innate immune system that comprises several small proteins activated by sequential cleavages. The majority of these complement components, such as components 3a (C3a) and C5a, are chemotactic and pro-inflflammatory. However, in this study, we revealed an inhibitory role of complement component 8 gamma (C8G) in neuroinflflammation. In patients with Alzheimer's disease, who exhibit strong neuroinflflammation, we found higher C8G levels in brain tissue......2021-02-22