1. Introduction Thyroid hormones are tyrosine monoiodide produced by thyroid follicular epithelial cells, this kind of hormone includes tetraiodothyronine( Thyroxine, T4), Triiodothyronine (T3), and reverse T3（rT3）. Both T3 and T4 have physiological activity, but with different action time and intensity. T4 has low physiological activity, slow reaction, and long functioning time, while T3 is totally on the contrary. The in vivo study shows, it’s T3 that works in physiological action and most of T4 functions when they turn to T3. That is to say, T4 is more likely a Prehormone, and rT3 does not have obvious physiological activity. T4 get deiodination by deiodinase, which is......2014-10-23

N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP) is synthesized by heart muscle cells, after secreted into the blood, it will be decomposed into BNP (the concrete introduction of the BNP, please pay attention to BNP - important markers of heart failure) and NT-BNP by endoproteinases (figure 1). As NT-BNP is characterized by non-biological activity, long half-life in the body, and easy to track for a long time, so it can be used as a clinical marker for cardiovascular disease surveillance, and cardiovascular researchers at home and abroad show great interest in it. In 2004 and 2008, the international experts systematically elaborated characteristics and clinical applications of BNP ......2014-10-23

Alzheimer's disease (AD), the most common cause of dementia, was named after its founder, German psychiatrist and neuropathologist Alois Alzheimer. The main symptom of AD is continuously nerve dysfunction, and its main pathogenic symptom is atrophy of cerebral cortex and certain subcortical region. With the progress of the disease, the patients will loss their long-term memory and physical function gradually, and ultimately lead to death. Because AD is becoming a great public health crisis, research programs about the disease are increasing recently. While exploring the mechanism of the disease, three hypotheses had been established. For each of the hypothesis, Cloud-Clone Corp......2014-10-23

CUZD1 is strictly regulated by estrogen in two key reproductive tissues, the uterus and oviduct. Spatio-temporal analyses reveal that CUZD1 mRNA is expressed in a highly stage-specific manner in the uterus and oviduct, and its expression is restricted to the surface epithelium of both of these tissues. Nucleotide sequence analysis of the full-length CUZD1 cDNA indicates that it has an open reading frame of 1821 nucleotides encoding a putative protein of 607 amino acids with a single transmembrane domain and a short cytoplasmic tail. Although the precise function of CUZD1 is not clear, presently, its unique pattern of expression in the uterus and oviduct, and its regulation by estrogen,......2014-04-11

Obesity is the major risk factor for cardiovascular disease, but its mechanism is still not clear. Researchers have proposed two possible hypotheses on obesity-induced diseases: inflammation and increase of oxidative stress. The study of obesity mechanism depends on the study of obesity related bio-markers, and it is very important to find the optimal bio-markers to improve the accuracy of cardiovascular diseases diagnosis. The common used bio-markers are inflammation related bio-markers, for instance, IL6, Adiponectin, Leptin, etc, and oxidative stress related bio-markers, for instance, oxLDL, PPARg, MCP1, etc. Cloud-Clone Corp. has developed a series of quantitative ELISA kits for......2014-03-13

The homology of certain protein in different species is very high, from 95% to 100%. For example, actin beta(ACTb), which is the main component of cytoskeleton microfilament, is widely distributed in various tissues. The protein is expressed by housekeeping gene, and its highly conservative, it shares 100% homology in different mammal species, such as human, rat, mouse, rabbit, pig, bovine, sheep, etc. Based on the characteristics of this kind of protein, we know when an antibody could identify one protein, then it can recognize and combine with this protein in different species. As for this phenomenon, Cloud-Clone Corp. developes a new type of ELISA detection kit with antibody whic......2014-02-08