Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)

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NTN; ABCD3; C3Xkine; CXC3; CXC3C; NTT; SCYD1; ABCD3; FKN; Neurotactin; Fractalkine; Small Inducible Cytokine Subfamily D(Cys-X3-Cys)Member 1

Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)

CX3CL1 is the unique member of the CX3C chemokine subfamily. The membrane-anchored protein, which is primarily expressed on the inflamed endothelium, serves as an adhesion protein promoting the retention of monocytes and T cells in inflamed tissue. The soluble form resembles more a conventional chemokine and strongly induces chemotaxis. Both chemotaxis and adhesion are mediated by the G protein-coupled receptor CX3CR1. CX3CL1 has been thought to play an important role in inflammation, and indeed, accumulating evidence indicates that CX3CL1/CX3CR1 are involved in the pathogenesis of various inflammatory disorders such as glomerulonephritis, rheumatoid arthritis and systemic lupus erythematosus (SLE).

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA040Hu01Recombinant Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)SDS-PAGE; WB; ELISA; IP.
RPA040Hu02Recombinant Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)SDS-PAGE; WB; ELISA; IP.
APA040Hu01Active Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)Cell culture; Activity Assays; In vivo assays.
AntibodiesPAA040Hu01Polyclonal Antibody to Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)WB, ICC, IHC-P, IHC-F, ELISA
MAA040Hu22Monoclonal Antibody to Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)WB, ICC, IHC-P, IHC-F, ELISA
PAA040Hu02Polyclonal Antibody to Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)WB, ICC, IHC-P, IHC-F, ELISA
LAA040Hu81FITC-Linked Polyclonal Antibody to Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)IHC;ICC;IF;WB
LAA040Hu71Biotin-Linked Polyclonal Antibody to Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)IHC;WB;ELISA
Assay KitsSEA040HuELISA Kit for Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)Enzyme-linked immunosorbent assay for Antigen Detection
SCA040HuCLIA Kit for Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)Chemiluminescent immunoassay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA040Mu01Recombinant Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)SDS-PAGE; WB; ELISA; IP.
RPA040Mu02Recombinant Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA040Mu01Polyclonal Antibody to Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)WB, ICC, IHC-P, IHC-F, ELISA
PAA040Mu02Polyclonal Antibody to Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA040MuELISA Kit for Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)Enzyme-linked immunosorbent assay for Antigen Detection
SCA040MuCLIA Kit for Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)Chemiluminescent immunoassay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA040Ra01Recombinant Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)SDS-PAGE; WB; ELISA; IP.
APA040Ra01Active Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)Cell culture; Activity Assays; In vivo assays.
AntibodiesPAA040Ra01Polyclonal Antibody to Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)WB, ICC, IHC-P, IHC-F, ELISA
LAA040Ra81FITC-Linked Polyclonal Antibody to Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)IHC;ICC;IF;WB
LAA040Ra71Biotin-Linked Polyclonal Antibody to Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)IHC;WB;ELISA
MAA040Ra21Monoclonal Antibody to Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA040RaELISA Kit for Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)Enzyme-linked immunosorbent assay for Antigen Detection
SCA040RaCLIA Kit for Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)Chemiluminescent immunoassay for Antigen Detection
  1. "A new class of membrane-bound chemokine with a CX3C motif."Nature 385:640-644(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Enrichment of glycopeptides for glycan structure and attachment site identification."Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Solution structure and dynamics of the CX3C chemokine domain of fractalkine and its interaction with an N-terminal fragment of CX3CR1."Biochemistry 38:1402-1414(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The crystal structure of the chemokine domain of fractalkine shows a novel quaternary arrangement."J. Biol. Chem. 275:23187-23193(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Structural basis of chemokine sequestration by CrmD, a poxvirus-encoded tumor necrosis factor receptor."PLoS Pathog. 7:E1002162-E1002162(2011) [PubMed] [Europe PMC] [Abstract]