Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)

[Edit]

NTN; ABCD3; C3Xkine; CXC3; CXC3C; NTT; SCYD1; ABCD3; FKN; Neurotactin; Fractalkine; Small Inducible Cytokine Subfamily D(Cys-X3-Cys)Member 1

Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)

CX3CL1 is the unique member of the CX3C chemokine subfamily. The membrane-anchored protein, which is primarily expressed on the inflamed endothelium, serves as an adhesion protein promoting the retention of monocytes and T cells in inflamed tissue. The soluble form resembles more a conventional chemokine and strongly induces chemotaxis. Both chemotaxis and adhesion are mediated by the G protein-coupled receptor CX3CR1. CX3CL1 has been thought to play an important role in inflammation, and indeed, accumulating evidence indicates that CX3CL1/CX3CR1 are involved in the pathogenesis of various inflammatory disorders such as glomerulonephritis, rheumatoid arthritis and systemic lupus erythematosus (SLE).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA040Hu01 Recombinant Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA040Hu02 Recombinant Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) Positive Control; Immunogen; SDS-PAGE; WB.
APA040Hu01 Active Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) Cell culture; Activity Assays.
Antibodies PAA040Hu01 Polyclonal Antibody to Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) WB; IHC; ICC; IP.
MAA040Hu22 Monoclonal Antibody to Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) WB; IHC; ICC; IP.
PAA040Hu02 Polyclonal Antibody to Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) WB; IHC; ICC; IP.
LAA040Hu81 FITC-Linked Polyclonal Antibody to Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) WB; IHC; ICC; IF.
LAA040Hu71 Biotin-Linked Polyclonal Antibody to Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) WB; IHC; ICC.
Assay Kits SEA040Hu ELISA Kit for Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA040Hu CLIA Kit for Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA040Mu01 Recombinant Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA040Mu02 Recombinant Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA040Mu01 Polyclonal Antibody to Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) WB; IHC; ICC; IP.
PAA040Mu02 Polyclonal Antibody to Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) WB; IHC; ICC; IP.
Assay Kits SEA040Mu ELISA Kit for Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA040Mu CLIA Kit for Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA040Ra01 Recombinant Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) Positive Control; Immunogen; SDS-PAGE; WB.
APA040Ra01 Active Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) Cell culture; Activity Assays.
Antibodies PAA040Ra01 Polyclonal Antibody to Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) WB; IHC; ICC; IP.
LAA040Ra81 FITC-Linked Polyclonal Antibody to Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) WB; IHC; ICC; IF.
LAA040Ra71 Biotin-Linked Polyclonal Antibody to Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) WB; IHC; ICC.
MAA040Ra21 Monoclonal Antibody to Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) WB; IHC; ICC; IP.
Assay Kits SEA040Ra ELISA Kit for Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA040Ra CLIA Kit for Chemokine C-X3-C-Motif Ligand 1 (CX3CL1) Chemiluminescent immunoassay for Antigen Detection.
  1. "A new class of membrane-bound chemokine with a CX3C motif."Nature 385:640-644(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Enrichment of glycopeptides for glycan structure and attachment site identification."Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Solution structure and dynamics of the CX3C chemokine domain of fractalkine and its interaction with an N-terminal fragment of CX3CR1."Biochemistry 38:1402-1414(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The crystal structure of the chemokine domain of fractalkine shows a novel quaternary arrangement."J. Biol. Chem. 275:23187-23193(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Structural basis of chemokine sequestration by CrmD, a poxvirus-encoded tumor necrosis factor receptor."PLoS Pathog. 7:E1002162-E1002162(2011) [PubMed] [Europe PMC] [Abstract]