Interleukin 12B (IL12B)

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p40; IL12-B; CLMF2; NKSF2; Natural Killer Cell Stimulatory Factor 2; Cytotoxic Lymphocyte Maturation Factor 2; Interleukin 23, P40 Subunit

Interleukin 12B (IL12B)

IL12B, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA058Hu01Recombinant Interleukin 12B (IL12B)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA058Hu01Polyclonal Antibody to Interleukin 12B (IL12B)WB, ICC, IHC-P, IHC-F, ELISA
MAA058Hu22Monoclonal Antibody to Interleukin 12B (IL12B)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA058HuELISA Kit for Interleukin 12B (IL12B)Enzyme-linked immunosorbent assay

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA058Mu01Recombinant Interleukin 12B (IL12B)SDS-PAGE; WB; ELISA; IP.
RPA058Mu02Recombinant Interleukin 12B (IL12B)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA058Mu01Polyclonal Antibody to Interleukin 12B (IL12B)WB, ICC, IHC-P, IHC-F, ELISA
PAA058Mu02Polyclonal Antibody to Interleukin 12B (IL12B)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA058MuELISA Kit for Interleukin 12B (IL12B)Enzyme-linked immunosorbent assay

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA058Ra01Recombinant Interleukin 12B (IL12B)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA058Ra01Polyclonal Antibody to Interleukin 12B (IL12B)WB, ICC, IHC-P, IHC-F, ELISA
MAA058Ra21Monoclonal Antibody to Interleukin 12B (IL12B)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA058RaELISA Kit for Interleukin 12B (IL12B)Enzyme-linked immunosorbent assay

Organism species: Cavia (Guinea pig )

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA058Gu01Recombinant Interleukin 12B (IL12B)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA058Gu01Polyclonal Antibody to Interleukin 12B (IL12B)WB, ICC, IHC-P, IHC-F, ELISA
MAA058Gu21Monoclonal Antibody to Interleukin 12B (IL12B)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA058GuELISA Kit for Interleukin 12B (IL12B)Enzyme-linked immunosorbent assay

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA058Ca01Recombinant Interleukin 12B (IL12B)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA058Ca01Polyclonal Antibody to Interleukin 12B (IL12B)WB, ICC, IHC-P, IHC-F, ELISA
MAA058Ca21Monoclonal Antibody to Interleukin 12B (IL12B)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA058CaELISA Kit for Interleukin 12B (IL12B)Enzyme-linked immunosorbent assay

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA058Po01Recombinant Interleukin 12B (IL12B)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA058Po01Polyclonal Antibody to Interleukin 12B (IL12B)WB, ICC, IHC-P, IHC-F, ELISA
MAA058Po21Monoclonal Antibody to Interleukin 12B (IL12B)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA058PoELISA Kit for Interleukin 12B (IL12B)Enzyme-linked immunosorbent assay

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA058Bo01Recombinant Interleukin 12B (IL12B)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA058Bo01Polyclonal Antibody to Interleukin 12B (IL12B)WB, ICC, IHC-P, IHC-F, ELISA
MAA058Bo21Monoclonal Antibody to Interleukin 12B (IL12B)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA058BoELISA Kit for Interleukin 12B (IL12B)Enzyme-linked immunosorbent assay

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA058Cp01Recombinant Interleukin 12B (IL12B)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA058Cp01Polyclonal Antibody to Interleukin 12B (IL12B)WB, ICC, IHC-P, IHC-F, ELISA
MAA058Cp21Monoclonal Antibody to Interleukin 12B (IL12B)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA058CpELISA Kit for Interleukin 12B (IL12B)Enzyme-linked immunosorbent assay

Organism species: Equus caballus; Equine (Horse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA058Eq01Recombinant Interleukin 12B (IL12B)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA058Eq01Polyclonal Antibody to Interleukin 12B (IL12B)WB, ICC, IHC-P, IHC-F, ELISA
MAA058Eq21Monoclonal Antibody to Interleukin 12B (IL12B)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA058EqELISA Kit for Interleukin 12B (IL12B)Enzyme-linked immunosorbent assay

Organism species: Chicken (Gallus)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA058Ga01Recombinant Interleukin 12B (IL12B)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA058Ga01Polyclonal Antibody to Interleukin 12B (IL12B)WB, ICC, IHC-P, IHC-F, ELISA
MAA058Ga21Monoclonal Antibody to Interleukin 12B (IL12B)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA058GaELISA Kit for Interleukin 12B (IL12B)Enzyme-linked immunosorbent assay

Organism species: Danio rerio (Zebrafish)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA058Fi01Recombinant Interleukin 12B (IL12B)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA058Fi01Polyclonal Antibody to Interleukin 12B (IL12B)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Interleukin 12B (IL12B)CLIA Kit Customized Service Offer
n/aELISA Kit for Interleukin 12B (IL12B)ELISA Kit Customized Service Offer
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  9. "Inherited interleukin 12 deficiency in a child with bacille Calmette-Guerin and Salmonella enteritidis disseminated infection."J. Clin. Invest. 102:2035-2040(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12." Immunity 13:715-725(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Inherited interleukin-12 deficiency: IL12B genotype and clinical phenotype of 13 patients from six kindreds." Am. J. Hum. Genet. 70:336-348(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis."Hum. Genet. 122:201-206(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Genetic variants of the IL-23R pathway: association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritis."J. Invest. Dermatol. 129:355-358(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12."EMBO J. 19:3530-3541(2000) [PubMed] [Europe PMC] [Abstract]
  15. "Crystal structures of the pro-inflammatory cytokine interleukin-23 and its complex with a high-affinity neutralizing antibody."J. Mol. Biol. 382:942-955(2008) [PubMed] [Europe PMC] [Abstract]
  16. "The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12."J. Mol. Biol. 382:931-941(2008) [PubMed] [Europe PMC] [Abstract]