-90063.jpg)
Interleukin 17 (IL-17; also known as IL-17A) is a 30 - 35 kDa variably glycosylated homodimeric protein that belongs to a unique family of cysteine-knot related proteins. Its sequence was originally isolated from an activated rodent hybridoma and termed CTLA-8 . It is synthesized as a 155 amino acid (aa) precursor that contains a 23 aa signal sequence and a 15 kDa, 132 aa mature segment. Although there are two intrachain disulfide bonds that create a ring reminiscent of those found in cysteine-knot proteins, the actual closed knot structure does not appear to form. IL-17 has one potential N-linked glycosylation site.IL-17, a T cell-derived proinf lammatory cytokine, is produced by TCRα/β+CD4-CD8- thymocytes, as well as by activated CD4+ and CD4+CD45RO+ memory T cells.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA063Hu01 | Recombinant Interleukin 17 (IL17) | Positive Control; Immunogen; SDS-PAGE; WB. |
| EPA063Hu61 | Eukaryotic Interleukin 17 (IL17) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA063Hu01 | Active Interleukin 17 (IL17) | Cell culture; Activity Assays. | |
| Antibodies | PAA063Hu01 | Polyclonal Antibody to Interleukin 17 (IL17) | WB |
| MAA063Hu22 | Monoclonal Antibody to Interleukin 17 (IL17) | IHC | |
| PAA063Hu06 | Polyclonal Antibody to Interleukin 17 (IL17) | WB; IHC; ICC; IP. | |
| MAA063Hu21 | Monoclonal Antibody to Interleukin 17 (IL17) | WB | |
| MAA063Hu23 | Monoclonal Antibody to Interleukin 17 (IL17) | IHC | |
| MAA063Hu24 | Monoclonal Antibody to Interleukin 17 (IL17) | IHC | |
| MAA063Hu25 | Monoclonal Antibody to Interleukin 17 (IL17) | IHC | |
| Assay Kits | SEA063Hu | ELISA Kit for Interleukin 17 (IL17) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA063Hu | CLIA Kit for Interleukin 17 (IL17) | Chemiluminescent immunoassay for Antigen Detection. | |
| HEA063Hu | High Sensitive ELISA Kit for Interleukin 17 (IL17) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA063Mu01 | Recombinant Interleukin 17 (IL17) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA063Mu02 | Recombinant Interleukin 17 (IL17) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA063Mu61 | Active Interleukin 17 (IL17) | Cell culture; Activity Assays. | |
| Antibodies | PAA063Mu01 | Polyclonal Antibody to Interleukin 17 (IL17) | WB; IHC; ICC; IP. |
| PAA063Mu02 | Polyclonal Antibody to Interleukin 17 (IL17) | WB; IHC; ICC; IP. | |
| MAA063Mu22 | Monoclonal Antibody to Interleukin 17 (IL17) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA063Mu | ELISA Kit for Interleukin 17 (IL17) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA063Mu | CLIA Kit for Interleukin 17 (IL17) | Chemiluminescent immunoassay for Antigen Detection. | |
| HEA063Mu | High Sensitive ELISA Kit for Interleukin 17 (IL17) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA063Ra01 | Recombinant Interleukin 17 (IL17) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA063Ra01 | Polyclonal Antibody to Interleukin 17 (IL17) | WB; IHC; ICC; IP. |
| MAA063Ra21 | Monoclonal Antibody to Interleukin 17 (IL17) | WB; IHC | |
| MAA063Ra22 | Monoclonal Antibody to Interleukin 17 (IL17) | WB; IHC | |
| MAA063Ra23 | Monoclonal Antibody to Interleukin 17 (IL17) | IHC | |
| Assay Kits | SEA063Ra | ELISA Kit for Interleukin 17 (IL17) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Cavia (Guinea pig )
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Interleukin 17 (IL17) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Interleukin 17 (IL17) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Interleukin 17 (IL17) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SEA063Gu | ELISA Kit for Interleukin 17 (IL17) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA063Rb01 | Recombinant Interleukin 17 (IL17) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA063Rb51 | Polyclonal Antibody to Interleukin 17 (IL17) | WB; IHC; ICC; IP. |
| LAA063Rb71 | Biotin-Linked Polyclonal Antibody to Interleukin 17 (IL17) | WB; IHC; ICC. | |
| MAA063Rb21 | Monoclonal Antibody to Interleukin 17 (IL17) | IHC | |
| PAA063Rb01 | Polyclonal Antibody to Interleukin 17 (IL17) | WB; IHC; ICC; IP. | |
| MAA063Rb22 | Monoclonal Antibody to Interleukin 17 (IL17) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA063Rb | ELISA Kit for Interleukin 17 (IL17) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Canis familiaris; Canine (Dog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA063Ca01 | Recombinant Interleukin 17 (IL17) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA063Ca01 | Polyclonal Antibody to Interleukin 17 (IL17) | IHC |
| MAA063Ca21 | Monoclonal Antibody to Interleukin 17 (IL17) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA063Ca | ELISA Kit for Interleukin 17 (IL17) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA063Po01 | Recombinant Interleukin 17 (IL17) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA063Po61 | Active Interleukin 17 (IL17) | Cell culture; Activity Assays. | |
| Antibodies | PAA063Po01 | Polyclonal Antibody to Interleukin 17 (IL17) | WB; IHC; ICC; IP. |
| MAA063Po21 | Monoclonal Antibody to Interleukin 17 (IL17) | IHC | |
| Assay Kits | SEA063Po | ELISA Kit for Interleukin 17 (IL17) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA063Bo01 | Recombinant Interleukin 17 (IL17) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA063Bo01 | Polyclonal Antibody to Interleukin 17 (IL17) | WB; IHC; ICC; IP. |
| MAA063Bo21 | Monoclonal Antibody to Interleukin 17 (IL17) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA063Bo | ELISA Kit for Interleukin 17 (IL17) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Ovis aries; Ovine (Sheep)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA063Ov01 | Recombinant Interleukin 17 (IL17) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA063Ov01 | Polyclonal Antibody to Interleukin 17 (IL17) | WB; IHC; ICC; IP. |
| MAA063Ov21 | Monoclonal Antibody to Interleukin 17 (IL17) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA063Ov | ELISA Kit for Interleukin 17 (IL17) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Equus caballus; Equine (Horse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA063Eq01 | Recombinant Interleukin 17 (IL17) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA063Eq01 | Polyclonal Antibody to Interleukin 17 (IL17) | WB; IHC; ICC; IP. |
| MAA063Eq21 | Monoclonal Antibody to Interleukin 17 (IL17) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA063Eq | ELISA Kit for Interleukin 17 (IL17) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Chicken (Gallus)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA063Ga01 | Recombinant Interleukin 17 (IL17) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA063Ga01 | Polyclonal Antibody to Interleukin 17 (IL17) | WB |
| LAA063Ga81 | FITC-Linked Polyclonal Antibody to Interleukin 17 (IL17) | WB; IHC; ICC; IF. | |
| LAA063Ga71 | Biotin-Linked Polyclonal Antibody to Interleukin 17 (IL17) | WB | |
| MAA063Ga21 | Monoclonal Antibody to Interleukin 17 (IL17) | WB; IHC; ICC; IP. | |
| Assay Kits | CEA063Ga | ELISA Kit for Interleukin 17 (IL17) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SEA063Ga | ELISA Kit for Interleukin 17 (IL17) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines."J. Exp. Med. 183:2593-2603(1996) [PubMed] [Europe PMC] [Abstract]
- "Human IL-17: a novel cytokine derived from T cells."J. Immunol. 155:5483-5486(1995) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
- "Structure of IL-17A in complex with a potent, fully human neutralizing antibody." J. Mol. Biol. 394:905-921(2009) [PubMed] [Europe PMC] [Abstract]