Prokineticin Receptor 2 (PKR2)

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PROKR2; KAL3; GPR73L1; GPR73b; GPRg2; G Protein-Coupled receptor 73-Like 1

Prokineticin Receptor 2 (PKR2)
Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins.
Lin et al. (2002) cloned human GPR73L1 (PROKR2) by PCR of a pooled testis and fetal brain cDNA library. They also cloned GPR73 (PROKR1), which shares 85% overall sequence identity with GPR73L1. The greatest divergence between the proteins is in the N terminus, and both share about 80% sequence identity with mouse Gpr73. RT-PCR detected expression of GPR73L1 in brain, testis, small intestine, ovary, thyroid, pituitary, and salivary gland.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA075Hu01Recombinant Prokineticin Receptor 2 (PKR2)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA075Hu01Polyclonal Antibody to Prokineticin Receptor 2 (PKR2)WB, ICC, IHC-P, IHC-F, ELISA
MAA075Hu22Monoclonal Antibody to Prokineticin Receptor 2 (PKR2)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA075HuELISA Kit for Prokineticin Receptor 2 (PKR2)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Prokineticin Receptor 2 (PKR2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Prokineticin Receptor 2 (PKR2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Prokineticin Receptor 2 (PKR2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Prokineticin Receptor 2 (PKR2)CLIA Kit Customized Service Offer
n/aELISA Kit for Prokineticin Receptor 2 (PKR2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Prokineticin Receptor 2 (PKR2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Prokineticin Receptor 2 (PKR2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Prokineticin Receptor 2 (PKR2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Prokineticin Receptor 2 (PKR2)CLIA Kit Customized Service Offer
n/aELISA Kit for Prokineticin Receptor 2 (PKR2)ELISA Kit Customized Service Offer
  1. "Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor."J. Biol. Chem. 277:19276-19280(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and characterization of prokineticin receptors."Biochim. Biophys. Acta 1579:173-179(2002) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Evidence that prokineticin receptor 2 exists as a dimer in vivo."Cell. Mol. Life Sci. 68:2919-2929(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2."PLoS Genet. 2:1648-1652(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum."J. Clin. Endocrinol. Metab. 93:3551-3559(2008) [PubMed] [Europe PMC] [Abstract]
  8. "PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activity."Hum. Mol. Genet. 18:75-81(2009) [PubMed] [Europe PMC] [Abstract]
  9. "SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome." PLoS Genet. 8:E1002896-E1002896(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism." Am. J. Hum. Genet. 92:725-743(2013) [PubMed] [Europe PMC] [Abstract]
  11. "The prevalence of CHD7 missense versus truncating mutations is higher in patients with Kallmann syndrome than in typical CHARGE patients." J. Clin. Endocrinol. Metab. 99:E2138-2143(2014) [PubMed] [Europe PMC] [Abstract]