Interleukin 5 (IL5)

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E-CSF; ESGF; EDF; TRF; Colony-Stimulating Factor,Eosinophil; T-Cell replacing Factor; B Cell Differentiation Factor I; Eosinophil Differentiation Factor

Interleukin 5 (IL5)

IL-5 is secreted by a restricted number of mesenchymal cell types. In its native state, mature IL-5 is synthesized as a 115 aa, highly glycosylated 22 kDa monomer that forms a 40-50 kDa disulfide-linked homodimer. 

Although the content of  carbohydrate  is  high, carbohydrate is not needed for bioactivity.  Monomeric IL-5 has no activity and requires a homodimer for function, which is in contrast to the receptor-related IL-3 and GM-CSF cytokines that exist only as monomers.  Just as one IL-3 and GM-CSF monomer binds to one receptor, one IL-5 homodimer is able to engage only one IL-5 receptor.  It has been suggested that IL-5 (as a dimmer) undergoes a general conformational change after binding to one receptor molecule and this change precludes binding to a second receptor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA078Hu01 Recombinant Interleukin 5 (IL5) Positive Control; Immunogen; SDS-PAGE; WB.
EPA078Hu61 Eukaryotic Interleukin 5 (IL5) Positive Control; Immunogen; SDS-PAGE; WB.
APA078Hu01 Active Interleukin 5 (IL5) Cell culture; Activity Assays.
APA078Hu61 Active Interleukin 5 (IL5) Cell culture; Activity Assays; In vivo assays.
EPA078Hu41 Eukaryotic Interleukin 5 (IL5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA078Hu01 Polyclonal Antibody to Interleukin 5 (IL5) WB; IHC; ICC; IP.
MAA078Hu22 Monoclonal Antibody to Interleukin 5 (IL5) WB; IHC; ICC; IP.
MAA078Hu21 Monoclonal Antibody to Interleukin 5 (IL5) WB; IHC; ICC; IP.
Assay Kits SEA078Hu ELISA Kit for Interleukin 5 (IL5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA078Mu01 Recombinant Interleukin 5 (IL5) Positive Control; Immunogen; SDS-PAGE; WB.
RPA078Mu02 Recombinant Interleukin 5 (IL5) Positive Control; Immunogen; SDS-PAGE; WB.
EPA078Mu61 Eukaryotic Interleukin 5 (IL5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA078Mu01 Polyclonal Antibody to Interleukin 5 (IL5) WB; IHC; ICC; IP.
PAA078Mu02 Polyclonal Antibody to Interleukin 5 (IL5) WB; IHC; ICC; IP.
Assay Kits SEA078Mu ELISA Kit for Interleukin 5 (IL5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA078Ra01 Recombinant Interleukin 5 (IL5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA078Ra01 Polyclonal Antibody to Interleukin 5 (IL5) WB; IHC; ICC; IP.
MAA078Ra21 Monoclonal Antibody to Interleukin 5 (IL5) WB; IHC; ICC; IP.
Assay Kits SEA078Ra ELISA Kit for Interleukin 5 (IL5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Cavia (Guinea pig )

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA078Gu01 Recombinant Interleukin 5 (IL5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA078Gu01 Polyclonal Antibody to Interleukin 5 (IL5) WB; IHC; ICC; IP.
MAA078Gu21 Monoclonal Antibody to Interleukin 5 (IL5) WB; IHC; ICC; IP.
Assay Kits SEA078Gu ELISA Kit for Interleukin 5 (IL5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA078Rb01 Recombinant Interleukin 5 (IL5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Interleukin 5 (IL5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 5 (IL5) Polyclonal Antibody Customized Service Offer
Assay Kits SEA078Rb ELISA Kit for Interleukin 5 (IL5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA078Si01 Recombinant Interleukin 5 (IL5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA078Si01 Polyclonal Antibody to Interleukin 5 (IL5) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Interleukin 5 (IL5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 5 (IL5) ELISA Kit Customized Service Offer

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA078Ca01 Recombinant Interleukin 5 (IL5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA078Ca01 Polyclonal Antibody to Interleukin 5 (IL5) WB; IHC; ICC; IP.
MAA078Ca21 Monoclonal Antibody to Interleukin 5 (IL5) WB; IHC; ICC; IP.
Assay Kits SEA078Ca ELISA Kit for Interleukin 5 (IL5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA078Po01 Recombinant Interleukin 5 (IL5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA078Po01 Polyclonal Antibody to Interleukin 5 (IL5) WB; IHC; ICC; IP.
MAA078Po21 Monoclonal Antibody to Interleukin 5 (IL5) WB; IHC; ICC; IP.
Assay Kits SEA078Po ELISA Kit for Interleukin 5 (IL5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA078Bo01 Recombinant Interleukin 5 (IL5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA078Bo01 Polyclonal Antibody to Interleukin 5 (IL5) WB; IHC; ICC; IP.
MAA078Bo21 Monoclonal Antibody to Interleukin 5 (IL5) WB; IHC; ICC; IP.
Assay Kits SEA078Bo ELISA Kit for Interleukin 5 (IL5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA078Cp01 Recombinant Interleukin 5 (IL5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA078Cp01 Polyclonal Antibody to Interleukin 5 (IL5) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Interleukin 5 (IL5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 5 (IL5) ELISA Kit Customized Service Offer

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA078Eq01 Recombinant Interleukin 5 (IL5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA078Eq01 Polyclonal Antibody to Interleukin 5 (IL5) WB; IHC; ICC; IP.
MAA078Eq21 Monoclonal Antibody to Interleukin 5 (IL5) WB; IHC; ICC; IP.
Assay Kits SEA078Eq ELISA Kit for Interleukin 5 (IL5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA078Ga01 Recombinant Interleukin 5 (IL5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA078Ga01 Polyclonal Antibody to Interleukin 5 (IL5) WB; IHC; ICC; IP.
MAA078Ga21 Monoclonal Antibody to Interleukin 5 (IL5) WB; IHC; ICC; IP.
Assay Kits SEA078Ga ELISA Kit for Interleukin 5 (IL5) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning of cDNA for human T-cell replacing factor (interleukin-5) and comparison with the murine homologue."Nucleic Acids Res. 14:9149-9158(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and structure of the human interleukin-5 gene."J. Biol. Chem. 262:16580-16584(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5)."Proc. Natl. Acad. Sci. U.S.A. 84:6629-6633(1987) [PubMed] [Europe PMC] [Abstract]
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  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Structure of recombinant human interleukin 5 produced by Chinese hamster ovary cells."J. Biochem. 107:292-297(1990) [PubMed] [Europe PMC] [Abstract]
  7. "Human interleukin-5 expressed in Escherichia coli: assignment of the disulfide bridges of the purified unglycosylated protein."FEBS Lett. 283:61-64(1991) [PubMed] [Europe PMC] [Abstract]
  8. "A novel dimer configuration revealed by the crystal structure at 2.4-A resolution of human interleukin-5."Nature 363:172-176(1993) [PubMed] [Europe PMC] [Abstract]
  9. "Structure analysis of the IL-5 ligand-receptor complex reveals a wrench-like architecture for IL-5Ralpha."Structure 19:1864-1875(2011) [PubMed] [Europe PMC] [Abstract]