Interleukin 6 (IL6)

[Edit]

MGI2-A; MGI2A; HGF; BSF2; HSF; IFNB2; B-Cell Stimulatory Factor-2; Hybridoma/Plasmacytoma Growth Factor; Hepatocyte Stimulating Factor; Cytotoxic T-Cell Differentiation Factor

Interleukin 6 (IL6)

IL-6 is a multifunctional protein produced by lymphoid and non-lymphoid cells, and by normal and transformed cells, including T cells, monocyte/macrophages, fibroblasts, hepatocytes, vascular endothelial cells, cardiac myxomas, bladder cell carcinomas, myelomas, astrogliomas and glioblastomas. The production of IL-6 in these various cells is regulated, either positively or negatively, by a variety of signals including mitogens, antigenic stimulation, lipopolysaccharides, IL-1, TNF, PDGF and viruses. On the basis of its various activities, IL-6 has also been called interferon-β2 (IFN-β2), 26 kDa protein, B-cell stimulatory factor-2 (BSF-2), hybridoma/plasmacytoma growth factor, hepatocyte stimulating factor, cytotoxic T-cell differentiation factor, and macrophage-granulocyte inducing factor 2A (MGI-2A).

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA079Hu01Recombinant Interleukin 6 (IL6)SDS-PAGE; WB; ELISA; IP.
EPA079Hu61Eukaryotic Interleukin 6 (IL6)SDS-PAGE; WB; ELISA; IP; CoIP; EMSA; Reporter Assays; Purification; Amine Reactive Labeling.
APA079Hu01Active Interleukin 6 (IL6)Cell culture; Activity Assays; In vivo assays.
APA079Hu61Active Interleukin 6 (IL6)Cell culture; Activity Assays; In vivo assays.
AntibodiesPAA079Hu01Polyclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
MAA079Hu22Monoclonal Antibody to Interleukin 6 (IL6)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
LAA079Hu71Biotin-Linked Polyclonal Antibody to Interleukin 6 (IL6)IHC;WB;ELISA
PAA079Hu06Polyclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
LAA079Hu72Biotin-Linked Monoclonal Antibody to Interleukin 6 (IL6)WB; ICC; IHC-P; IHC-F; IF; ELISA.
Assay KitsSEA079HuELISA Kit for Interleukin 6 (IL6)Enzyme-linked immunosorbent assay for Antigen Detection
SCA079HuCLIA Kit for Interleukin 6 (IL6)Chemiluminescent immunoassay for Antigen Detection
HEA079HuHigh Sensitive ELISA Kit for Interleukin 6 (IL6)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA079Mu01Recombinant Interleukin 6 (IL6)SDS-PAGE; WB; ELISA; IP.
RPA079Mu02Recombinant Interleukin 6 (IL6)SDS-PAGE; WB; ELISA; IP.
EPA079Mu61Eukaryotic Interleukin 6 (IL6)SDS-PAGE; WB; ELISA; IP; CoIP; EMSA; Reporter Assays; Purification; Amine Reactive Labeling.
APA079Mu61Active Interleukin 6 (IL6)Cell culture; Activity Assays; In vivo assays.
AntibodiesPAA079Mu01Polyclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
LAA079Mu71Biotin-Linked Polyclonal Antibody to Interleukin 6 (IL6)IHC;WB;ELISA
LAA079Mu81FITC-Linked Polyclonal Antibody to Interleukin 6 (IL6)IHC;ICC;IF;WB
PAA079Mu02Polyclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
MAA079Mu21Monoclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
PAA079Mu06Polyclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA079MuELISA Kit for Interleukin 6 (IL6)Enzyme-linked immunosorbent assay for Antigen Detection
SCA079MuCLIA Kit for Interleukin 6 (IL6)Chemiluminescent immunoassay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA079Ra01Recombinant Interleukin 6 (IL6)SDS-PAGE; WB; ELISA; IP.
EPA079Ra61Eukaryotic Interleukin 6 (IL6)SDS-PAGE; WB; ELISA; IP; CoIP; EMSA; Reporter Assays; Purification; Amine Reactive Labeling.
APA079Ra61Active Interleukin 6 (IL6)Cell culture; Activity Assays; In vivo assays.
AntibodiesPAA079Ra01Polyclonal Antibody to Interleukin 6 (IL6)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
LAA079Ra71Biotin-Linked Polyclonal Antibody to Interleukin 6 (IL6)IHC;WB;ELISA
MAA079Ra21Monoclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
PAA079Ra06Polyclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA079RaELISA Kit for Interleukin 6 (IL6)Enzyme-linked immunosorbent assay for Antigen Detection
SCA079RaCLIA Kit for Interleukin 6 (IL6)Chemiluminescent immunoassay for Antigen Detection
HEA079RaHigh Sensitive ELISA Kit for Interleukin 6 (IL6)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA079Rb01Recombinant Interleukin 6 (IL6)SDS-PAGE; WB; ELISA; IP; CoIP; ReporterAssays; Purification; Amine Reactive Labeling.
RPA079Rb02Recombinant Interleukin 6 (IL6)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA079Rb52Polyclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
PAA079Rb51Polyclonal Antibody to Interleukin 6 (IL6)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
LAA079Rb71Biotin-Linked Polyclonal Antibody to Interleukin 6 (IL6)WB; ICC; IHC-P; IHC-F; IF; ELISA.
MAA079Rb21Monoclonal Antibody to Interleukin 6 (IL6)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
Assay KitsSEA079RbELISA Kit for Interleukin 6 (IL6)Enzyme-linked immunosorbent assay for Antigen Detection
SCA079RbCLIA Kit for Interleukin 6 (IL6)Chemiluminescent immunoassay for Antigen Detection
HEA079RbHigh Sensitive ELISA Kit for Interleukin 6 (IL6)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA079Si01Recombinant Interleukin 6 (IL6)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA079Si01Polyclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
MAA079Si22Monoclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
LAA079Si71Biotin-Linked Polyclonal Antibody to Interleukin 6 (IL6)IHC;WB;ELISA
LAA079Si81FITC-Linked Polyclonal Antibody to Interleukin 6 (IL6)IHC;ICC;IF;WB
Assay KitsSEA079SiELISA Kit for Interleukin 6 (IL6)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA079Ca01Recombinant Interleukin 6 (IL6)SDS-PAGE; WB; ELISA; IP.
EPA079Ca61Eukaryotic Interleukin 6 (IL6)SDS-PAGE; WB; ELISA; IP; CoIP; EMSA; Reporter Assays; Purification; Amine Reactive Labeling.
APA079Ca61Active Interleukin 6 (IL6)Cell culture; Activity Assays; In vivo assays.
AntibodiesPAA079Ca01Polyclonal Antibody to Interleukin 6 (IL6)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
MAA079Ca21Monoclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
PAA079Ca06Polyclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA079CaELISA Kit for Interleukin 6 (IL6)Enzyme-linked immunosorbent assay for Antigen Detection
SCA079CaCLIA Kit for Interleukin 6 (IL6)Chemiluminescent immunoassay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA079Po01Recombinant Interleukin 6 (IL6)SDS-PAGE; WB; ELISA; IP.
EPA079Po61Eukaryotic Interleukin 6 (IL6)SDS-PAGE; WB; ELISA; IP; CoIP; EMSA; Reporter Assays; Purification; Amine Reactive Labeling.
APA079Po61Active Interleukin 6 (IL6)Cell culture; Activity Assays; In vivo assays.
AntibodiesPAA079Po01Polyclonal Antibody to Interleukin 6 (IL6)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
LAA079Po71Biotin-Linked Polyclonal Antibody to Interleukin 6 (IL6)IHC;WB;ELISA
LAA079Po81FITC-Linked Polyclonal Antibody to Interleukin 6 (IL6)IHC;ICC;IF;WB
MAA079Po21Monoclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
PAA079Po06Polyclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA079PoELISA Kit for Interleukin 6 (IL6)Enzyme-linked immunosorbent assay for Antigen Detection
SCA079PoCLIA Kit for Interleukin 6 (IL6)Chemiluminescent immunoassay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA079Bo01Recombinant Interleukin 6 (IL6)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA079Bo01Polyclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
MAA079Bo21Monoclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA079BoELISA Kit for Interleukin 6 (IL6)Enzyme-linked immunosorbent assay for Antigen Detection
SCA079BoCLIA Kit for Interleukin 6 (IL6)Chemiluminescent immunoassay for Antigen Detection
HEA079BoHigh Sensitive ELISA Kit for Interleukin 6 (IL6)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA079Cp01Recombinant Interleukin 6 (IL6)SDS-PAGE; WB; ELISA; IP.
CPA079Cp21OVA Conjugated Interleukin 6 (IL6)Immunogen; Coating Antigen; Blocking Peptide; ELISA.
AntibodiesPAA079Cp01Polyclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
LAA079Cp71Biotin-Linked Polyclonal Antibody to Interleukin 6 (IL6)IHC;WB;ELISA
MAA079Cp21Monoclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
PAA079Cp08Polyclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA079CpELISA Kit for Interleukin 6 (IL6)Enzyme-linked immunosorbent assay for Antigen Detection
HEA079CpHigh Sensitive ELISA Kit for Interleukin 6 (IL6)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA079Ov01Recombinant Interleukin 6 (IL6)SDS-PAGE; WB; ELISA; IP.
RPA079Ov02Recombinant Interleukin 6 (IL6)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA079Ov01Polyclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
PAA079Ov02Polyclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
MAA079Ov22Monoclonal Antibody to Interleukin 6 (IL6)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
LAA079Ov71Biotin-Linked Polyclonal Antibody to Interleukin 6 (IL6)IHC;WB;ELISA
LAA079Ov72Biotin-Linked Monoclonal Antibody to Interleukin 6 (IL6)WB; ICC; IHC-P; IHC-F; IF; ELISA.
Assay KitsSEA079OvELISA Kit for Interleukin 6 (IL6)Enzyme-linked immunosorbent assay for Antigen Detection
HEA079OvHigh Sensitive ELISA Kit for Interleukin 6 (IL6)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Interleukin 6 (IL6)Recombinant Protein Customized Service Offer
AntibodiesLAA079Eq71Biotin-Linked Polyclonal Antibody to Interleukin 6 (IL6)IHC;WB;ELISA
MAA079Eq21Monoclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA079EqELISA Kit for Interleukin 6 (IL6)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Chicken (Gallus)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA079Ga01Recombinant Interleukin 6 (IL6)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA079Ga01Polyclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
MAA079Ga21Monoclonal Antibody to Interleukin 6 (IL6)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA079GaELISA Kit for Interleukin 6 (IL6)Enzyme-linked immunosorbent assay for Antigen Detection
  1. "Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin."Nature 324:73-76(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene."EMBO J. 6:2939-2945(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Anti-beta-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the beta 2 interferon involved."Proc. Natl. Acad. Sci. U.S.A. 83:8957-8961(1986) [PubMed] [Europe PMC] [Abstract]
  4. "Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines."EMBO J. 5:2529-2537(1986) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular cloning and expression of hybridoma growth factor in Escherichia coli."J. Immunol. 139:4116-4121(1987) [PubMed] [Europe PMC] [Abstract]
  6. "Deletion of 3' untranslated region of human BSF-2 mRNA causes stabilization of the mRNA and high-level expression in mouse NIH3T3 cells."Biochem. Biophys. Res. Commun. 163:1056-1062(1989) [PubMed] [Europe PMC] [Abstract]
  7. "Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts."Eur. J. Biochem. 159:625-632(1986) [PubMed] [Europe PMC] [Abstract]
  8. "Interleukin 6: identification as a hematopoietic colony-stimulating factor."Behring Inst. Mitt. 83:40-47(1988) [PubMed] [Europe PMC] [Abstract]
  9. "Stable and efficient expression of human interleukin-6 cDNA in mammalian cells after gene transfer."Zhonghua Zhong Liu Za Zhi 14:340-344(1992) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Separation and comparison of two monokines with lymphocyte-activating factor activity: IL-1 beta and hybridoma growth factor (HGF). Identification of leukocyte-derived HGF as IL-6."J. Immunol. 140:1534-1541(1988) [PubMed] [Europe PMC] [Abstract]
  12. "Interleukin 6 is the principal cytolytic T lymphocyte differentiation factor for thymocytes in human leukocyte conditioned medium."J. Mol. Cell. Immunol. 4:203-211(1989) [PubMed] [Europe PMC] [Abstract]
  13. "Marked cell-type-specific differences in glycosylation of human interleukin-6."Cytokine 3:204-211(1991) [PubMed] [Europe PMC] [Abstract]
  14. "Structure, stability and biological properties of a N-terminally truncated form of recombinant human interleukin-6 containing a single disulfide bond."Eur. J. Biochem. 227:573-581(1995) [PubMed] [Europe PMC] [Abstract]
  15. "Disulfide structures of human interleukin-6 are similar to those of human granulocyte colony stimulating factor."Arch. Biochem. Biophys. 272:144-151(1989) [PubMed] [Europe PMC] [Abstract]
  16. "Evidence for the importance of a positive charge and an alpha-helical structure of the C-terminus for biological activity of human IL-6."FEBS Lett. 282:265-267(1991) [PubMed] [Europe PMC] [Abstract]
  17. "Folding topologies of human interleukin-6 and its mutants as studied by NMR spectroscopy."Biochemistry 35:273-281(1996) [PubMed] [Europe PMC] [Abstract]
  18. "Solution structure of recombinant human interleukin-6."J. Mol. Biol. 268:468-481(1997) [PubMed] [Europe PMC] [Abstract]
  19. "1.9-A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling."EMBO J. 16:989-997(1997) [PubMed] [Europe PMC] [Abstract]
  20. "The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis."J. Clin. Invest. 102:1369-1376(1998) [PubMed] [Europe PMC] [Abstract]
  21. "An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus."Blood 96:2562-2567(2000) [PubMed] [Europe PMC] [Abstract]
  22. "A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density."J. Hum. Genet. 46:267-272(2001) [PubMed] [Europe PMC] [Abstract]
  23. "Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women."J. Hum. Genet. 48:243-248(2003) [PubMed] [Europe PMC] [Abstract]