Leptin (LEP)

[Edit]

OB; OBS; Obesity Homolog; Obesity Factor; Obese Protein

Leptin (LEP)

Leptin is a protein hormone with important effects in regulating body weight, metabolism and reproductive function. Leptin is a 16-kD protein that plays a critical role in the regulation of body weight by inhibiting food intake and stimulating energy expenditure. Defects in leptin production cause severe hereditary obesity in rodents and humans. In addition to its effects on body weight, leptin has a variety of other functions, including the regulation of hematopoiesis, angiogenesis, wound healing, and the immune and inflammatory response. Leptin acts through the leptin receptor (LEPR), a single-transmembrane-domain receptor of the cytokine receptor family, which is found in many tissues in several alternatively spliced forms. The LEP gene is the human homolog of the gene (ob) mutant in the mouse 'obese' phenotype.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA084Hu01Recombinant Leptin (LEP)SDS-PAGE; WB; ELISA; IP.
APA084Hu01Active Leptin (LEP)Cell culture; Activity Assays; In vivo assays.
AntibodiesLAA084Hu71Biotin-Linked Polyclonal Antibody to Leptin (LEP)IHC;WB;ELISA
LAA084Hu81FITC-Linked Polyclonal Antibody to Leptin (LEP)IHC;ICC;IF;WB
PAA084Hu01Polyclonal Antibody to Leptin (LEP)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA084HuELISA Kit for Leptin (LEP)Enzyme-linked immunosorbent assay for Antigen Detection
SCA084HuCLIA Kit for Leptin (LEP)Chemiluminescent immunoassay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA084Mu01Recombinant Leptin (LEP)SDS-PAGE; WB; ELISA; IP.
RPA084Mu02Recombinant Leptin (LEP)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA084Mu01Polyclonal Antibody to Leptin (LEP)WB, ICC, IHC-P, IHC-F, ELISA
LAA084Mu71Biotin-Linked Polyclonal Antibody to Leptin (LEP)IHC;WB;ELISA
LAA084Mu81FITC-Linked Polyclonal Antibody to Leptin (LEP)IHC;ICC;IF;WB
PAA084Mu02Polyclonal Antibody to Leptin (LEP)WB, ICC, IHC-P, IHC-F, ELISA
MAA084Mu21Monoclonal Antibody to Leptin (LEP)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
Assay KitsSEA084MuELISA Kit for Leptin (LEP)Enzyme-linked immunosorbent assay for Antigen Detection
SCA084MuCLIA Kit for Leptin (LEP)Chemiluminescent immunoassay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA084Ra01Recombinant Leptin (LEP)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA084Ra01Polyclonal Antibody to Leptin (LEP)WB, ICC, IHC-P, IHC-F, ELISA
LAA084Ra71Biotin-Linked Polyclonal Antibody to Leptin (LEP)IHC;WB;ELISA
MAA084Ra21Monoclonal Antibody to Leptin (LEP)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA084RaELISA Kit for Leptin (LEP)Enzyme-linked immunosorbent assay for Antigen Detection
SCA084RaCLIA Kit for Leptin (LEP)Chemiluminescent immunoassay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA084Rb01Recombinant Leptin (LEP)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA084Rb51Polyclonal Antibody to Leptin (LEP)WB, ICC, IHC-P, IHC-F, ELISA
MAA084Rb21Monoclonal Antibody to Leptin (LEP)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA084RbELISA Kit for Leptin (LEP)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA084Ca01Recombinant Leptin (LEP)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA084Ca01Polyclonal Antibody to Leptin (LEP)WB, ICC, IHC-P, IHC-F, ELISA
MAA084Ca21Monoclonal Antibody to Leptin (LEP)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA084CaELISA Kit for Leptin (LEP)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA084Po01Recombinant Leptin (LEP)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA084Po01Polyclonal Antibody to Leptin (LEP)WB, ICC, IHC-P, IHC-F, ELISA
MAA084Po21Monoclonal Antibody to Leptin (LEP)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA084PoELISA Kit for Leptin (LEP)Enzyme-linked immunosorbent assay for Antigen Detection
SCA084PoCLIA Kit for Leptin (LEP)Chemiluminescent immunoassay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA084Bo01Recombinant Leptin (LEP)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA084Bo01Polyclonal Antibody to Leptin (LEP)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
MAA084Bo21Monoclonal Antibody to Leptin (LEP)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
LAA084Bo71Biotin-Linked Polyclonal Antibody to Leptin (LEP)WB; ICC; IHC-P; IHC-F; IF; ELISA.
Assay KitsSEA084BoELISA Kit for Leptin (LEP)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA084Cp01Recombinant Leptin (LEP)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA084Cp01Polyclonal Antibody to Leptin (LEP)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Leptin (LEP)CLIA Kit Customized Service Offer
n/aELISA Kit for Leptin (LEP)ELISA Kit Customized Service Offer

Organism species: Equus caballus; Equine (Horse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA084Eq01Recombinant Leptin (LEP)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA084Eq01Polyclonal Antibody to Leptin (LEP)WB, ICC, IHC-P, IHC-F, ELISA
MAA084Eq21Monoclonal Antibody to Leptin (LEP)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA084EqELISA Kit for Leptin (LEP)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Chicken (Gallus)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA084Ga01Recombinant Leptin (LEP)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA084Ga01Polyclonal Antibody to Leptin (LEP)WB, ICC, IHC-P, IHC-F, ELISA
MAA084Ga21Monoclonal Antibody to Leptin (LEP)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA084GaELISA Kit for Leptin (LEP)Enzyme-linked immunosorbent assay for Antigen Detection
  1. "Positional cloning of the mouse obese gene and its human homologue."Nature 372:425-432(1994) [PubMed] [Europe PMC] [Abstract]
  2. ErratumNature 374:479-479(1995)
  3. "Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue."Diabetes 44:855-858(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Genomic structure and promoter analysis of the human obese gene."J. Biol. Chem. 271:3971-3974(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Structural organization and chromosomal assignment of the human obese gene."J. Biol. Chem. 270:27728-27733(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Human obese gene: molecular screening in Japanese and Asian Indian NIDDM patients associated with obesity."Diabetes 45:675-678(1996) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily."J. Biol. Chem. 274:22729-22738(1999) [PubMed] [Europe PMC] [Abstract]
  9. ErratumJ. Biol. Chem. 274:28058-28058(1999)
  10. "Leptin is a four-helix bundle: secondary structure by NMR."FEBS Lett. 407:239-242(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of the obese protein leptin-E100."Nature 387:206-209(1997) [PubMed] [Europe PMC] [Abstract]
  12. "A novel polymorphism in the leptin gene."Hum. Mutat. 12:220-220(1998)
  13. "A leptin missense mutation associated with hypogonadism and morbid obesity."Nat. Genet. 18:213-215(1998) [PubMed] [Europe PMC] [Abstract]