Monocyte Chemotactic Protein 2 (MCP2)

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CCL8; CCL-8; SCYA8; MCP-2; HC14; Chemokine C-C-Motif Ligand 8; Small Inducible Cytokine Subfamily A(Cys-Cys)Member 8; Monocyte Chemoattractant Protein 2

Monocyte Chemotactic Protein 2 (MCP2)

Chemokine (C-C motif) ligand 8 (CCL8) is a small cytokine belonging to the CC chemokine family that was once called monocyte chemotactic protein-2 (MCP-2).

The CCL8 protein is produced as a precursor containing 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. MCP-2 is chemotactic for and activates a many different immune cells, including mast cells, eosinophils and basophils, (that are implicated in allergic responses), and monocytes, T cells, and NK cells that are involved in the inflammatory response. CCL8 elicits its effects by binding to several different cell surface receptors called chemokine receptors.These receptors include CCR1, CCR2B and CCR5.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA088Hu01 Recombinant Monocyte Chemotactic Protein 2 (MCP2) Positive Control; Immunogen; SDS-PAGE; WB.
APA088Hu01 Active Monocyte Chemotactic Protein 2 (MCP2) Cell culture; Activity Assays.
Antibodies PAA088Hu01 Polyclonal Antibody to Monocyte Chemotactic Protein 2 (MCP2) WB; IHC; ICC; IP.
MAA088Hu22 Monoclonal Antibody to Monocyte Chemotactic Protein 2 (MCP2) WB; IHC; ICC; IP.
Assay Kits SEA088Hu ELISA Kit for Monocyte Chemotactic Protein 2 (MCP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA088Mu01 Recombinant Monocyte Chemotactic Protein 2 (MCP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA088Mu01 Polyclonal Antibody to Monocyte Chemotactic Protein 2 (MCP2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Monocyte Chemotactic Protein 2 (MCP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Monocyte Chemotactic Protein 2 (MCP2) ELISA Kit Customized Service Offer

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA088Ca01 Recombinant Monocyte Chemotactic Protein 2 (MCP2) Positive Control; Immunogen; SDS-PAGE; WB.
EPA088Ca61 Eukaryotic Monocyte Chemotactic Protein 2 (MCP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA088Ca01 Polyclonal Antibody to Monocyte Chemotactic Protein 2 (MCP2) WB; IHC; ICC; IP.
MAA088Ca21 Monoclonal Antibody to Monocyte Chemotactic Protein 2 (MCP2) WB; IHC; ICC; IP.
Assay Kits SEA088Ca ELISA Kit for Monocyte Chemotactic Protein 2 (MCP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA088Po01 Recombinant Monocyte Chemotactic Protein 2 (MCP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA088Po01 Polyclonal Antibody to Monocyte Chemotactic Protein 2 (MCP2) WB; IHC; ICC; IP.
MAA088Po21 Monoclonal Antibody to Monocyte Chemotactic Protein 2 (MCP2) WB; IHC; ICC; IP.
Assay Kits SEA088Po ELISA Kit for Monocyte Chemotactic Protein 2 (MCP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA088Bo01 Recombinant Monocyte Chemotactic Protein 2 (MCP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA088Bo01 Polyclonal Antibody to Monocyte Chemotactic Protein 2 (MCP2) WB; IHC; ICC; IP.
MAA088Bo21 Monoclonal Antibody to Monocyte Chemotactic Protein 2 (MCP2) WB; IHC; ICC; IP.
Assay Kits SEA088Bo ELISA Kit for Monocyte Chemotactic Protein 2 (MCP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA088Eq01 Recombinant Monocyte Chemotactic Protein 2 (MCP2) Positive Control; Immunogen; SDS-PAGE; WB.
EPA088Eq61 Eukaryotic Monocyte Chemotactic Protein 2 (MCP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA088Eq01 Polyclonal Antibody to Monocyte Chemotactic Protein 2 (MCP2) WB; IHC; ICC; IP.
Assay Kits SEA088Eq ELISA Kit for Monocyte Chemotactic Protein 2 (MCP2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2."Genomics 40:323-331(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Human monocyte chemotactic protein-2: cDNA cloning and regulated expression of mRNA in mesenchymal cells."Biochem. Biophys. Res. Commun. 231:726-730(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and expression of a gamma-interferon-inducible gene in monocytes: a new member of a cytokine gene family."Int. Immunol. 1:388-397(1989) [PubMed] [Europe PMC] [Abstract]
  5. "Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family."J. Exp. Med. 176:59-65(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3."FEBS Lett. 395:277-282(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Posttranslational modifications affect the activity of the human monocyte chemotactic proteins MCP-1 and MCP-2: identification of MCP-2(6-76) as a natural chemokine inhibitor."J. Immunol. 160:4034-4041(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine that interacts with multiple receptors."Biochemistry 39:14075-14081(2000) [PubMed] [Europe PMC] [Abstract]