Nerve Growth Factor (NGF)

[Edit]

NGFB; Beta-NGF; HSAN5; NGF-B; Beta-Nerve Growth Factor

Nerve Growth Factor (NGF)

Nerve growth factor (NGF) is a naturally occurring molecule in the body which stimulates the growth and differentiation of the sympathetic and certain sensory nerves. NGF is a protein that consists of 3 types of polypeptide chains -- alpha, beta and gamma -- that interact to form the protein. The NGF beta chain (NGFB) is solely responsible for the nerve growth stimulating activity of NGF. The NGFB gene is in chromosome band 1p22. An ointment containing NGF has been reported to help heal bedsores (decubiti).This complex contains 2 identical 118-amino acid beta-chains, which are solely responsible for nerve growth stimulating activity of NGF. Human DNA fragments coding for NGF were identified by Zabel et al. (1984) using a mouse submaxillary cDNA probe.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA105Hu01Recombinant Nerve Growth Factor (NGF)SDS-PAGE; WB; ELISA; IP; CoIP; Reporter Assays; Purification; Amine Reactive Labeling.
EPA105Hu61Eukaryotic Nerve Growth Factor (NGF)SDS-PAGE; WB; ELISA; IP; CoIP; EMSA; Reporter Assays; Purification; Amine Reactive Labeling.
APA105Hu01Active Nerve Growth Factor (NGF)Cell culture; Activity Assays; In vivo assays.
AntibodiesPAA105Hu01Polyclonal Antibody to Nerve Growth Factor (NGF)WB, ICC, IHC-P, IHC-F, ELISA
MAA105Hu22Monoclonal Antibody to Nerve Growth Factor (NGF)WB, ICC, IHC-P, IHC-F, ELISA
LAA105Hu71Biotin-Linked Polyclonal Antibody to Nerve Growth Factor (NGF)IHC;WB;ELISA
PAA105Hu06Polyclonal Antibody to Nerve Growth Factor (NGF)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA105HuELISA Kit for Nerve Growth Factor (NGF)Enzyme-linked immunosorbent assay for Antigen Detection
SCA105HuCLIA Kit for Nerve Growth Factor (NGF)Chemiluminescent immunoassay for Antigen Detection
HEA105HuHigh Sensitive ELISA Kit for Nerve Growth Factor (NGF)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA105Mu01Recombinant Nerve Growth Factor (NGF)SDS-PAGE; WB; ELISA; IP.
RPA105Mu02Recombinant Nerve Growth Factor (NGF)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA105Mu01Polyclonal Antibody to Nerve Growth Factor (NGF)WB, ICC, IHC-P, IHC-F, ELISA
PAA105Mu02Polyclonal Antibody to Nerve Growth Factor (NGF)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA105MuELISA Kit for Nerve Growth Factor (NGF)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA105Ra01Recombinant Nerve Growth Factor (NGF)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA105Ra01Polyclonal Antibody to Nerve Growth Factor (NGF)WB, ICC, IHC-P, IHC-F, ELISA
MAA105Ra21Monoclonal Antibody to Nerve Growth Factor (NGF)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA105RaELISA Kit for Nerve Growth Factor (NGF)Enzyme-linked immunosorbent assay for Antigen Detection
SCA105RaCLIA Kit for Nerve Growth Factor (NGF)Chemiluminescent immunoassay for Antigen Detection

Organism species: Cavia (Guinea pig )

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA105Gu01Recombinant Nerve Growth Factor (NGF)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA105Gu01Polyclonal Antibody to Nerve Growth Factor (NGF)WB, ICC, IHC-P, IHC-F, ELISA
MAA105Gu21Monoclonal Antibody to Nerve Growth Factor (NGF)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA105GuELISA Kit for Nerve Growth Factor (NGF)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA105Si01Recombinant Nerve Growth Factor (NGF)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA105Si01Polyclonal Antibody to Nerve Growth Factor (NGF)WB, ICC, IHC-P, IHC-F, ELISA
MAA105Si21Monoclonal Antibody to Nerve Growth Factor (NGF)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA105SiELISA Kit for Nerve Growth Factor (NGF)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA105Po01Recombinant Nerve Growth Factor (NGF)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA105Po01Polyclonal Antibody to Nerve Growth Factor (NGF)WB, ICC, IHC-P, IHC-F, ELISA
MAA105Po21Monoclonal Antibody to Nerve Growth Factor (NGF)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA105PoELISA Kit for Nerve Growth Factor (NGF)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA105Bo01Recombinant Nerve Growth Factor (NGF)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA105Bo01Polyclonal Antibody to Nerve Growth Factor (NGF)WB, ICC, IHC-P, IHC-F, ELISA
MAA105Bo21Monoclonal Antibody to Nerve Growth Factor (NGF)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA105BoELISA Kit for Nerve Growth Factor (NGF)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Chicken (Gallus)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA105Ga01Recombinant Nerve Growth Factor (NGF)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA105Ga01Polyclonal Antibody to Nerve Growth Factor (NGF)WB, ICC, IHC-P, IHC-F, ELISA
MAA105Ga21Monoclonal Antibody to Nerve Growth Factor (NGF)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA105GaELISA Kit for Nerve Growth Factor (NGF)Enzyme-linked immunosorbent assay for Antigen Detection
  1. "Human beta-nerve growth factor gene sequence highly homologous to that of mouse."Nature 303:821-825(1983) [PubMed] [Europe PMC] [Abstract]
  2. "Sequence homology of human and mouse beta-NGF subunit genes."Cold Spring Harb. Symp. Quant. Biol. 48:435-442(1983) [PubMed] [Europe PMC] [Abstract]
  3. "cDNA sequence of human beta-NGF."Nucleic Acids Res. 18:4020-4020(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and sequencing of the gene for premature beta nerve growth factor."Zhongguo Ying Yong Sheng Li Xue Za Zhi 13:316-318(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Human-specific amino acid changes found in 103 protein-coding genes."Mol. Biol. Evol. 21:936-944(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary."Neuron 6:845-858(1991) [PubMed] [Europe PMC] [Abstract]
  9. "The trk proto-oncogene encodes a receptor for nerve growth factor."Cell 65:189-197(1991) [PubMed] [Europe PMC] [Abstract]
  10. "Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI."J. Biol. Chem. 285:11793-11799(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor."Nature 401:184-188(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  13. ErratumNat. Genet. 23:373-373(1999)
  14. "A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception."Hum. Mol. Genet. 13:799-805(2004) [PubMed] [Europe PMC] [Abstract]
  15. "A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy."J. Med. Genet. 48:131-135(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Frequency of mutations in the genes associated with hereditary sensory and autonomic neuropathy in a UK cohort." J. Neurol. 259:1673-1685(2012) [PubMed] [Europe PMC] [Abstract]