Prostaglandin E Synthase, Microsomal (PTGES)

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MGST1L1; MGST-IV; MGST1-L1; PGES; PIG12; PP102; PP1294; TP53I12; PGE Synthase; Tumor Protein p53 Inducible Protein 12; Glutathione S-Transferase 1-Like 1; MGST1-Like 1

Prostaglandin E Synthase, Microsomal (PTGES)

Prostaglandin E synthase is an enzyme involved in eicosanoid and glutathione metabolism, a member of MAPEG family. It generates prostaglandin E (PGE) from prostaglandin H2.The synthase generating PGE2 is a membrane-associated protein. Prostaglandin E synthase  is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis.The authors grouped the MGST1L1 protein with other members of the MAPEG (membrane-associated proteins in eicosanoid and glutathione metabolism) superfamily, which includes MGST2 , MGST3 , LTC4S, and FLAP (ALOX5AP).

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA167Hu01Recombinant Prostaglandin E Synthase, Microsomal (PTGES)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAA167Hu01Polyclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES)WB; IHC; ICC; IP.
MAA167Hu22Monoclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES)WB; IHC; ICC; IP.
LAA167Hu81FITC-Linked Polyclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES)WB; IHC; ICC; IF.
LAA167Hu71Biotin-Linked Polyclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES)WB; IHC; ICC.
Assay KitsSEA167HuELISA Kit for Prostaglandin E Synthase, Microsomal (PTGES)Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Prostaglandin E Synthase, Microsomal (PTGES)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Prostaglandin E Synthase, Microsomal (PTGES)CLIA Kit Customized Service Offer
n/aELISA Kit for Prostaglandin E Synthase, Microsomal (PTGES)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA167Ra01Recombinant Prostaglandin E Synthase, Microsomal (PTGES)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAA167Ra01Polyclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES)WB; IHC; ICC; IP.
MAA167Ra21Monoclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES)WB; IHC; ICC; IP.
Assay KitsSEA167RaELISA Kit for Prostaglandin E Synthase, Microsomal (PTGES)Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target."Proc. Natl. Acad. Sci. U.S.A. 96:7220-7225(1999) [PubMed] [Europe PMC] [Abstract]
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  10. "Structural basis for induced formation of the inflammatory mediator prostaglandin E2."Proc. Natl. Acad. Sci. U.S.A. 105:11110-11115(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily."Proc. Natl. Acad. Sci. U.S.A. 110:3806-3811(2013) [PubMed] [Europe PMC] [Abstract]