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Meprin A Beta (MEP1b)

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PPH Beta; Endopeptidase-2; Meprin B; PABA Peptide Hydrolase; N-benzoyl-L-tyrosyl-P-amino-Benzoic Acid Hydrolase Subunit Beta

Meprin A Beta (MEP1b)
CCC A173
HGNC 7020
MGI 96964
PubMed 10806353
RGD 3081
UniProt Q16820
Wiki MEP1B
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes and in leukocytes and certain cancer cells. Mature meprins are oligomers of evolutionarily related, separately encoded alpha and/or beta subunits. Homooligomers of meprin-alpha (MEP1A) are secreted; oligomers containing meprin-beta are associated with the plasma membrane.
Mep1b-null mice were born at half the expected mendelian ratio, but those that survived developed normally and were viable and fertile. Mutant mice lacked membrane-associated Mep1a in kidney and intestine, and microarray analysis indicated that renal gene expression profiles were different than those of wildtype mice.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA173Hu01 Recombinant Meprin A Beta (MEP1b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA173Hu01 Polyclonal Antibody to Meprin A Beta (MEP1b) WB; IHC; ICC; IP.
MAA173Hu21 Monoclonal Antibody to Meprin A Beta (MEP1b) WB; IHC; ICC; IP.
Assay Kits SEA173Hu ELISA Kit for Meprin A Beta (MEP1b) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Meprin A Beta (MEP1b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Meprin A Beta (MEP1b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Meprin A Beta (MEP1b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Meprin A Beta (MEP1b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Meprin A Beta (MEP1b) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA173Ra01 Recombinant Meprin A Beta (MEP1b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA173Ra01 Polyclonal Antibody to Meprin A Beta (MEP1b) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Meprin A Beta (MEP1b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Meprin A Beta (MEP1b) ELISA Kit Customized Service Offer
  1. "Polarised expression of human intestinal N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase (human meprin) alpha and beta subunits in Madin-Darby canine kidney cells."Eur. J. Biochem. 247:920-932(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cells."FEBS Lett. 335:367-375(1993) [PubMed] [Europe PMC] [Abstract]
  4. "N-Benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase beta (human meprinbeta). A 13-amino-acid sequence is required for proteolytic processing and subsequent secretion."Eur. J. Biochem. 261:421-429(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Human meprin beta: O-linked glycans in the intervening region of the type I membrane protein protect the C-terminal region from proteolytic cleavage and diminish its secretion."Biochem. J. 369:659-665(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Critical amino acids in the active site of meprin metalloproteinases for substrate and peptide bond specificity."J. Biol. Chem. 278:42545-42550(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Prointerleukin-18 is activated by meprin beta in vitro and in vivo in intestinal inflammation."J. Biol. Chem. 283:31371-31377(2008) [PubMed] [Europe PMC] [Abstract]
  8. "The metalloprotease meprinbeta processes E-cadherin and weakens intercellular adhesion."PLoS ONE 3:E2153-E2153(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases."Biochemistry 49:8599-8607(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Specific processing of tenascin-C by the metalloprotease meprinbeta neutralizes its inhibition of cell spreading."Matrix Biol. 29:31-42(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates."Mol. Cell. Proteomics 10:M111.009233.01-M111.009233.19(2011) [PubMed] [Europe PMC] [Abstract]
  12. "The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin beta and ADAM10."Cell. Mol. Life Sci. 70:309-333(2013) [PubMed] [Europe PMC] [Abstract]
  13. "Structural basis for the sheddase function of human meprin beta metalloproteinase at the plasma membrane."Proc. Natl. Acad. Sci. U.S.A. 109:16131-16136(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Diagnostic exome sequencing in persons with severe intellectual disability."N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]