Protease, Serine 1 (PRSS1)

[Edit]

TRP1; TRY1; TRY4; TRYP1; Trypsin 1; Cationic Trypsinogen; Beta-trypsin; Serine protease 1; Trypsin I

Protease, Serine 1 (PRSS1)

Trypsin-1 is  a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7.

Normally, cationic trypsinogen represents approximately two-thirds of total trypsinogen, while anionic trypsinogen makes up approximately one-third. Mesotrypsinogen is a minor species, accounting for less than 5% of trypsinogens or 0.5% of pancreatic juice proteins.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA230Hu01Recombinant Protease, Serine 1 (PRSS1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA230Hu01Polyclonal Antibody to Protease, Serine 1 (PRSS1)WB, ICC, IHC-P, IHC-F, ELISA
MAA230Hu22Monoclonal Antibody to Protease, Serine 1 (PRSS1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA230HuELISA Kit for Protease, Serine 1 (PRSS1)Enzyme-linked immunosorbent assay

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Protease, Serine 1 (PRSS1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Protease, Serine 1 (PRSS1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Protease, Serine 1 (PRSS1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Protease, Serine 1 (PRSS1)CLIA Kit Customized Service Offer
n/aELISA Kit for Protease, Serine 1 (PRSS1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA230Ra01Recombinant Protease, Serine 1 (PRSS1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA230Ra01Polyclonal Antibody to Protease, Serine 1 (PRSS1)WB, ICC, IHC-P, IHC-F, ELISA
MAA230Ra21Monoclonal Antibody to Protease, Serine 1 (PRSS1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA230RaELISA Kit for Protease, Serine 1 (PRSS1)Enzyme-linked immunosorbent assay
  1. "Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens."Gene 41:305-310(1986) [PubMed] [Europe PMC] [Abstract]
  2. "The complete 685-kilobase DNA sequence of the human beta T cell receptor locus."Science 272:1755-1762(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Chronic pancreatitis associated with an activation peptide mutation that facilitates trypsin activation."Gastroenterology 119:461-465(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of one- and two-chain forms of trypsinogen 1 produced by a human gastric adenocarcinoma cell line."Biochem. J. 303:187-190(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Immunoreactive anionic and cationic trypsin in human serum."Clin. Chim. Acta 184:31-46(1989) [PubMed] [Europe PMC] [Abstract]
  10. "Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene."Nat. Genet. 14:141-145(1996) [PubMed] [Europe PMC] [Abstract]
  11. "Mutational screening of patients with nonalcoholic chronic pancreatitis: identification of further trypsinogen variants."Am. J. Gastroenterol. 97:341-346(2002) [PubMed] [Europe PMC] [Abstract]
  12. , Submitted (MAR-2007) to UniProtKB
  13. "Human cationic trypsinogen is sulfated on Tyr154."FEBS J. 273:5044-5050(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids."PLoS ONE 9:E102063-E102063(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Crystal structure of human trypsin 1: unexpected phosphorylation of Tyr151."J. Mol. Biol. 259:995-1010(1996) [PubMed] [Europe PMC] [Abstract]
  16. "Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis."Gastroenterology 113:1063-1068(1997) [PubMed] [Europe PMC] [Abstract]
  17. "Mutations of the cationic trypsinogen in hereditary pancreatitis."Hum. Mutat. 12:39-43(1998) [PubMed] [Europe PMC] [Abstract]
  18. "A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis."Gastroenterology 117:7-10(1999) [PubMed] [Europe PMC] [Abstract]
  19. "Mutations in the cationic trypsinogen gene and evidence for genetic heterogeneity in hereditary pancreatitis."J. Med. Genet. 36:228-232(1999) [PubMed] [Europe PMC] [Abstract]
  20. "A CGC>CAT gene conversion-like event resulting in the R122H mutation in the cationic trypsinogen gene and its implication in the genotyping of pancreatitis."J. Med. Genet. 37:E36-E36(2000) [PubMed] [Europe PMC] [Abstract]
  21. "Novel cationic trypsinogen (PRSS1) N29T and R122C mutations cause autosomal dominant hereditary pancreatitis."Gut 50:271-272(2002) [PubMed] [Europe PMC] [Abstract]
  22. "Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2)."Hum. Mutat. 23:22-31(2004) [PubMed] [Europe PMC] [Abstract]
  23. "Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl."Hum. Mutat. 25:343-347(2005) [PubMed] [Europe PMC] [Abstract]
  24. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]