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Protease, Serine 1 (PRSS1)

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TRP1; TRY1; TRY4; TRYP1; Trypsin 1; Cationic Trypsinogen; Beta-trypsin; Serine protease 1; Trypsin I

Protease, Serine 1 (PRSS1)
CCC A230
HGNC 9475
MGI 3687012
PubMed 8683601
RGD 3417
UniProt P07477
Wiki PRSS1

Trypsin-1 is  a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7.

Normally, cationic trypsinogen represents approximately two-thirds of total trypsinogen, while anionic trypsinogen makes up approximately one-third. Mesotrypsinogen is a minor species, accounting for less than 5% of trypsinogens or 0.5% of pancreatic juice proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA230Hu01 Recombinant Protease, Serine 1 (PRSS1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA230Hu02 Recombinant Protease, Serine 1 (PRSS1) Positive Control; Immunogen; SDS-PAGE; WB.
APA230Hu02 Active Protease, Serine 1 (PRSS1) Cell culture; Activity Assays.
Antibodies PAA230Hu01 Polyclonal Antibody to Protease, Serine 1 (PRSS1) WB; IHC; ICC; IP.
MAA230Hu22 Monoclonal Antibody to Protease, Serine 1 (PRSS1) WB; IHC; ICC; IP.
PAA230Hu02 Polyclonal Antibody to Protease, Serine 1 (PRSS1) WB
Assay Kits SEA230Hu ELISA Kit for Protease, Serine 1 (PRSS1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA230Mu01 Recombinant Protease, Serine 1 (PRSS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA230Mu01 Polyclonal Antibody to Protease, Serine 1 (PRSS1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protease, Serine 1 (PRSS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protease, Serine 1 (PRSS1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA230Ra01 Recombinant Protease, Serine 1 (PRSS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA230Ra01 Polyclonal Antibody to Protease, Serine 1 (PRSS1) WB; IHC; ICC; IP.
MAA230Ra21 Monoclonal Antibody to Protease, Serine 1 (PRSS1) WB; IHC; ICC; IP.
Assay Kits SEA230Ra ELISA Kit for Protease, Serine 1 (PRSS1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  11. "Mutational screening of patients with nonalcoholic chronic pancreatitis: identification of further trypsinogen variants."Am. J. Gastroenterol. 97:341-346(2002) [PubMed] [Europe PMC] [Abstract]
  12. , Submitted (MAR-2007) to UniProtKB
  13. "Human cationic trypsinogen is sulfated on Tyr154."FEBS J. 273:5044-5050(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids."PLoS ONE 9:E102063-E102063(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Crystal structure of human trypsin 1: unexpected phosphorylation of Tyr151."J. Mol. Biol. 259:995-1010(1996) [PubMed] [Europe PMC] [Abstract]
  16. "Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis."Gastroenterology 113:1063-1068(1997) [PubMed] [Europe PMC] [Abstract]
  17. "Mutations of the cationic trypsinogen in hereditary pancreatitis."Hum. Mutat. 12:39-43(1998) [PubMed] [Europe PMC] [Abstract]
  18. "A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis."Gastroenterology 117:7-10(1999) [PubMed] [Europe PMC] [Abstract]
  19. "Mutations in the cationic trypsinogen gene and evidence for genetic heterogeneity in hereditary pancreatitis."J. Med. Genet. 36:228-232(1999) [PubMed] [Europe PMC] [Abstract]
  20. "A CGC>CAT gene conversion-like event resulting in the R122H mutation in the cationic trypsinogen gene and its implication in the genotyping of pancreatitis."J. Med. Genet. 37:E36-E36(2000) [PubMed] [Europe PMC] [Abstract]
  21. "Novel cationic trypsinogen (PRSS1) N29T and R122C mutations cause autosomal dominant hereditary pancreatitis."Gut 50:271-272(2002) [PubMed] [Europe PMC] [Abstract]
  22. "Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2)."Hum. Mutat. 23:22-31(2004) [PubMed] [Europe PMC] [Abstract]
  23. "Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl."Hum. Mutat. 25:343-347(2005) [PubMed] [Europe PMC] [Abstract]
  24. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]