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Cathepsin A (CTSA)

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CTS-A; GLB2; GSL; NGBE; PPCA; PPGB; Protective Protein For Beta-Galactosidase; Galactosialidosis; Carboxypeptidase C; Carboxypeptidase L

Cathepsin A (CTSA)
CCC A348
HGNC 9251
MGI 97748
PubMed 8725271
RGD 1309070
UniProt P10619
Wiki Cathepsin_A

Cathepsin A is a ubiquitously expressed multifunctional enzyme, with deamidase, esterase, and carboxypeptidase activities and a preference for substrates with hydrophobic amino acid residues at the P1-prime position. Association with CTSA, as part of the lysosomal multienzyme complex, is essential for stabilization of lysosomal beta-galactosidase (GLB1), as well as for activation of the lysosomal neuraminidase (NEU1) . Galjart et al. isolated cDNA encoding the human 'protective protein.' The cDNA directed the synthesis of a 452-amino acid precursor molecule that is processed in vivo to yield mature 'protective protein,' a heterodimer of 32 kD and 20 kD polypeptides held together by disulfide bridges. Because of homology to yeast carboxypeptidase Y, Galjart et al. suggested a protease activity for the 'protective protein.'

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA348Hu01 Recombinant Cathepsin A (CTSA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA348Hu01 Polyclonal Antibody to Cathepsin A (CTSA) WB; IHC; ICC; IP.
LAA348Hu81 FITC-Linked Polyclonal Antibody to Cathepsin A (CTSA) WB; IHC; ICC; IF.
LAA348Hu71 Biotin-Linked Polyclonal Antibody to Cathepsin A (CTSA) WB; IHC; ICC.
MAA348Hu21 Monoclonal Antibody to Cathepsin A (CTSA) WB; IHC; ICC; IP.
Assay Kits SEA348Hu ELISA Kit for Cathepsin A (CTSA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA348Mu01 Recombinant Cathepsin A (CTSA) Positive Control; Immunogen; SDS-PAGE; WB.
RPA348Mu02 Recombinant Cathepsin A (CTSA) Positive Control; Immunogen; SDS-PAGE; WB.
APA348Mu61 Active Cathepsin A (CTSA) Cell culture; Activity Assays.
Antibodies PAA348Mu01 Polyclonal Antibody to Cathepsin A (CTSA) WB; IHC; ICC; IP.
LAA348Mu81 FITC-Linked Polyclonal Antibody to Cathepsin A (CTSA) WB; IHC; ICC; IF.
LAA348Mu71 Biotin-Linked Polyclonal Antibody to Cathepsin A (CTSA) WB; IHC; ICC.
PAA348Mu02 Polyclonal Antibody to Cathepsin A (CTSA) WB; IHC; ICC; IP.
Assay Kits SEA348Mu ELISA Kit for Cathepsin A (CTSA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA348Ra01 Recombinant Cathepsin A (CTSA) Positive Control; Immunogen; SDS-PAGE; WB.
APA348Ra01 Active Cathepsin A (CTSA) Cell culture; Activity Assays.
EPA348Ra61 Eukaryotic Cathepsin A (CTSA) Positive Control; Immunogen; SDS-PAGE; WB.
APA348Ra61 Active Cathepsin A (CTSA) Cell culture; Activity Assays.
Antibodies PAA348Ra01 Polyclonal Antibody to Cathepsin A (CTSA) WB; IHC; ICC; IP.
LAA348Ra81 FITC-Linked Polyclonal Antibody to Cathepsin A (CTSA) WB; IHC; ICC; IF.
LAA348Ra71 Biotin-Linked Polyclonal Antibody to Cathepsin A (CTSA) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Cathepsin A (CTSA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cathepsin A (CTSA) ELISA Kit Customized Service Offer

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA348Ca01 Recombinant Cathepsin A (CTSA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA348Ca01 Polyclonal Antibody to Cathepsin A (CTSA) WB; IHC; ICC; IP.
LAA348Ca81 FITC-Linked Polyclonal Antibody to Cathepsin A (CTSA) WB; IHC; ICC; IF.
LAA348Ca71 Biotin-Linked Polyclonal Antibody to Cathepsin A (CTSA) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Cathepsin A (CTSA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cathepsin A (CTSA) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA348Po01 Recombinant Cathepsin A (CTSA) Positive Control; Immunogen; SDS-PAGE; WB.
EPA348Po61 Eukaryotic Cathepsin A (CTSA) Positive Control; Immunogen; SDS-PAGE; WB.
APA348Po61 Active Cathepsin A (CTSA) Cell culture; Activity Assays.
Antibodies PAA348Po01 Polyclonal Antibody to Cathepsin A (CTSA) WB; IHC; ICC; IP.
LAA348Po81 FITC-Linked Polyclonal Antibody to Cathepsin A (CTSA) WB; IHC; ICC; IF.
LAA348Po71 Biotin-Linked Polyclonal Antibody to Cathepsin A (CTSA) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Cathepsin A (CTSA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cathepsin A (CTSA) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA348Bo01 Recombinant Cathepsin A (CTSA) Positive Control; Immunogen; SDS-PAGE; WB.
APA348Bo61 Active Cathepsin A (CTSA) Cell culture; Activity Assays.
Antibodies PAA348Bo01 Polyclonal Antibody to Cathepsin A (CTSA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cathepsin A (CTSA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cathepsin A (CTSA) ELISA Kit Customized Service Offer
  1. "Expression of cDNA encoding the human 'protective protein' associated with lysosomal beta-galactosidase and neuraminidase: homology to yeast proteases."Cell 54:755-764(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A peptidase in human platelets that deamidates tachykinins. Probable identity with the lysosomal 'protective protein'."J. Biol. Chem. 265:11265-11272(1990) [PubMed] [Europe PMC] [Abstract]
  6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Human lysosomal protective protein has cathepsin A-like activity distinct from its protective function."J. Biol. Chem. 266:14754-14762(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Three-dimensional structure of the human 'protective protein': structure of the precursor form suggests a complex activation mechanism."Structure 3:1249-1259(1995) [PubMed] [Europe PMC] [Abstract]
  12. "A mutation in a mild form of galactosialidosis impairs dimerization of the protective protein and renders it unstable."EMBO J. 10:4041-4048(1991) [PubMed] [Europe PMC] [Abstract]
  13. "Protective protein gene mutations in galactosialidosis."J. Clin. Invest. 91:2393-2398(1993) [PubMed] [Europe PMC] [Abstract]
  14. "Molecular and biochemical analysis of protective protein/cathepsin A mutations: correlation with clinical severity in galactosialidosis."Hum. Mol. Genet. 5:1977-1987(1996) [PubMed] [Europe PMC] [Abstract]
  15. "Structural and functional study of K453E mutant protective protein/cathepsin A causing the late infantile form of galactosialidosis."J. Hum. Genet. 45:200-206(2000) [PubMed] [Europe PMC] [Abstract]