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Estrogen Receptor Beta (ERb)

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ER-B; ESRB; ESTRB; NR3A2; NR3-A2; ESR2; Estrogen Receptor 2; Nuclear Receptor Subfamily 3,Group A,Member 2

Estrogen Receptor Beta (ERb)
CCC A437
HGNC 3468
MGI 109392
PubMed 10579320
RGD 2582
UniProt Q92731
Wiki ERB

Estrogen receptor beta is a nuclear receptor which is activated by the sex hormone estrogen. a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA437Hu01 Recombinant Estrogen Receptor Beta (ERb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA437Hu01 Polyclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IP.
MAA437Hu22 Monoclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IP.
LAA437Hu71 Biotin-Linked Polyclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC.
LAA437Hu81 FITC-Linked Polyclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IF.
MAA437Hu21 Monoclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IP.
Assay Kits SEA437Hu ELISA Kit for Estrogen Receptor Beta (ERb) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA437Hu CLIA Kit for Estrogen Receptor Beta (ERb) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA437Mu01 Recombinant Estrogen Receptor Beta (ERb) Positive Control; Immunogen; SDS-PAGE; WB.
RPA437Mu02 Recombinant Estrogen Receptor Beta (ERb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA437Mu01 Polyclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IP.
LAA437Mu71 Biotin-Linked Polyclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC.
LAA437Mu81 FITC-Linked Polyclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IF.
PAA437Mu02 Polyclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IP.
Assay Kits SEA437Mu ELISA Kit for Estrogen Receptor Beta (ERb) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA437Ra01 Recombinant Estrogen Receptor Beta (ERb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA437Ra01 Polyclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IP.
MAA437Ra21 Monoclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IP.
Assay Kits SEA437Ra ELISA Kit for Estrogen Receptor Beta (ERb) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Cloning and characterization of human estrogen receptor beta isoforms."Biochem. Biophys. Res. Commun. 247:75-78(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Estrogen receptor-beta mRNA variants in human and murine tissues."Mol. Cell. Endocrinol. 138:199-203(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular cloning and characterization of human estrogen receptor beta cx: a potential inhibitor of estrogen action in human."Nucleic Acids Res. 26:3505-3512(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling."Proc. Natl. Acad. Sci. U.S.A. 103:13162-13167(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Cloning and characterization of human estrogen receptor beta promoter."Biochem. Biophys. Res. Commun. 275:682-689(2000) [PubMed] [Europe PMC] [Abstract]
  10. "ER beta: identification and characterization of a novel human estrogen receptor."FEBS Lett. 392:49-53(1996) [PubMed] [Europe PMC] [Abstract]
  11. "Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300."Cell 90:569-580(1997) [PubMed] [Europe PMC] [Abstract]
  12. "Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha."J. Biol. Chem. 272:25832-25838(1997) [PubMed] [Europe PMC] [Abstract]
  13. "Cloning and characterization of RAP250, a nuclear receptor coactivator."J. Biol. Chem. 275:5308-5317(2000) [PubMed] [Europe PMC] [Abstract]
  14. "CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant."Mol. Cell. Biol. 21:343-353(2001) [PubMed] [Europe PMC] [Abstract]
  15. "The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway."J. Biol. Chem. 276:46792-46797(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha."J. Biol. Chem. 277:28624-28630(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade."Proc. Natl. Acad. Sci. U.S.A. 99:14783-14788(2002) [PubMed] [Europe PMC] [Abstract]
  18. "ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor."Biochem. Biophys. Res. Commun. 317:54-59(2004) [PubMed] [Europe PMC] [Abstract]
  19. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  20. "An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling."J. Biol. Chem. 279:38721-38729(2004) [PubMed] [Europe PMC] [Abstract]
  21. "Selective hormone-dependent repression of estrogen receptor beta by a p38-activated ErbB2/ErbB3 pathway."J. Steroid Biochem. Mol. Biol. 94:23-37(2005) [PubMed] [Europe PMC] [Abstract]
  22. "CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells."Carcinogenesis 30:841-850(2009) [PubMed] [Europe PMC] [Abstract]