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Desmoglein 3 (DSG3)

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CDHF6; PVA; 130 kDa pemphigus vulgaris antigen; Cadherin family member 6

Desmoglein 3 (DSG3)
CCC A444
HGNC 3050
MGI 99499
PubMed 8601740
RGD 1592103
UniProt P32926
Wiki Desmoglein_3

  • Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune diseases of the skin which have as target antigens 2 different members of the desmoglein subfamily of the desmosomal cadherins: pemphigus vulgaris antigen (PVA) in the case of PV and desmoglein I in the case of PF. In pemphigus vulgaris, autoantibodies against PVA, a keratinocyte cell surface 130-kD glycoprotein, cause loss of cell-cell adhesion.

  • Amagai et al. used affinity-purified pemphigus vulgaris IgG to isolate cDNA, containing the entire coding sequence for PVA, from human keratinocyte expression libraries. Northern blot analysis indicated PV mRNA expression only in stratified squamous epithelia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA444Hu01 Recombinant Desmoglein 3 (DSG3) Positive Control; Immunogen; SDS-PAGE; WB.
RPA444Hu02 Recombinant Desmoglein 3 (DSG3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA444Hu01 Polyclonal Antibody to Desmoglein 3 (DSG3) WB; IHC; ICC; IP.
MAA444Hu22 Monoclonal Antibody to Desmoglein 3 (DSG3) WB; IHC; ICC; IP.
PAA444Hu02 Polyclonal Antibody to Desmoglein 3 (DSG3) WB; IHC; ICC; IP.
MAA444Hu21 Monoclonal Antibody to Desmoglein 3 (DSG3) WB; IHC; ICC; IP.
MAA444Hu23 Monoclonal Antibody to Desmoglein 3 (DSG3) WB; IHC; ICC; IP.
MAA444Hu24 Monoclonal Antibody to Desmoglein 3 (DSG3) WB; IHC; ICC; IP.
Assay Kits SEA444Hu ELISA Kit for Desmoglein 3 (DSG3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Desmoglein 3 (DSG3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Desmoglein 3 (DSG3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Desmoglein 3 (DSG3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Desmoglein 3 (DSG3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Desmoglein 3 (DSG3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Desmoglein 3 (DSG3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Desmoglein 3 (DSG3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Desmoglein 3 (DSG3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Desmoglein 3 (DSG3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Desmoglein 3 (DSG3) ELISA Kit Customized Service Offer
  1. "Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion."Cell 67:869-877(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]