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Kallikrein 5 (KLK5)

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KLK-L2; KLKL2; SCTE; Kallikrein-Related Peptidase 5; Kallikrein-like protein 2; Stratum corneum tryptic enzyme

Kallikrein 5 (KLK5)
CCC A451
HGNC 6366
MGI 1915918
PubMed 19820362
RGD 1593461
UniProt Q9Y337
Wiki KLK5

KLK5 belongs to the kallikrein subgroup of serine proteases, which have diverse physiologic functions in many tissues. For background information on kallikreins.Using a positional candidate approach to identify additional KLK genes on 19q13.3-q13.4, followed by EST database searching and PCR, Yousef and Diamandis (1999) obtained a cDNA encoding KLK5, which they called KLKL2. RT-PCR analysis detected expression primarily in brain, mammary gland, and testis, with lower levels in other tissues.Kim et al. (2001) noted that KLK5 is expressed in a subset of ovarian tumors. They found a strong positive correlation between KLK5 expression and tumor grade and disease stage. They concluded that KLK5 expression is associated with more aggressive forms of epithelial ovarian carcinoma.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA451Hu01 Recombinant Kallikrein 5 (KLK5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA451Hu01 Polyclonal Antibody to Kallikrein 5 (KLK5) WB; IHC; ICC; IP.
MAA451Hu22 Monoclonal Antibody to Kallikrein 5 (KLK5) WB; IHC; ICC; IP.
Assay Kits SEA451Hu ELISA Kit for Kallikrein 5 (KLK5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA451Mu01 Recombinant Kallikrein 5 (KLK5) Positive Control; Immunogen; SDS-PAGE; WB.
RPA451Mu02 Recombinant Kallikrein 5 (KLK5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA451Mu01 Polyclonal Antibody to Kallikrein 5 (KLK5) WB; IHC; ICC; IP.
PAA451Mu02 Polyclonal Antibody to Kallikrein 5 (KLK5) WB; IHC; ICC; IP.
Assay Kits SEA451Mu ELISA Kit for Kallikrein 5 (KLK5) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation."J. Biol. Chem. 274:30033-30040(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4."Anticancer Res. 19:2843-2852(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Differential expression of a human kallikrein 5 (KLK5) splice variant in ovarian and prostate cancer."Tumor Biol. 25:149-156(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor."J. Invest. Dermatol. 129:1656-1665(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of lympho-epithelial Kazal-type inhibitor 2 in human skin as a kallikrein-related peptidase 5-specific protease inhibitor."PLoS ONE 4:E4372-E4372(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Structural basis of the zinc inhibition of human tissue kallikrein 5."J. Mol. Biol. 373:1017-1031(2007) [PubMed] [Europe PMC] [Abstract]