Mineralocorticoid Receptor (MR)

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NR3C2; MLR; MCR; Aldosterone Receptor; Nuclear Receptor Subfamily 3 Group C Member 2

Mineralocorticoid Receptor (MR)

The mineralocorticoid receptor  is a receptor with high affinity for mineralocorticoids. It belongs to the steroid hormone receptor family where the ligand diffuses into cells, interacts with the receptor and results in a signal transduction affecting specific gene expression in the nucleus. The gene for the NR3C2 encodes for the 107 kDa MR protein. MR is expressed in many tissues, such as the kidney, colon, heart, central nervous system (hippocampus), brown adipose tissue and sweat glands. In epithelial tissues, its activation leads to the expression of proteins regulating ionic and water transports resulting in the reabsoprtion of sodium, and as a consequence an increase in extracellular volume, increase in blood pressure, and an excretion of potassium to maintain a normal salt concentration in the body.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA464Hu01Recombinant Mineralocorticoid Receptor (MR)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA464Hu01Polyclonal Antibody to Mineralocorticoid Receptor (MR)WB, ICC, IHC-P, IHC-F, ELISA
MAA464Hu22Monoclonal Antibody to Mineralocorticoid Receptor (MR)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA464HuELISA Kit for Mineralocorticoid Receptor (MR)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Mineralocorticoid Receptor (MR)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Mineralocorticoid Receptor (MR)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Mineralocorticoid Receptor (MR)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Mineralocorticoid Receptor (MR)CLIA Kit Customized Service Offer
n/aELISA Kit for Mineralocorticoid Receptor (MR)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA464Ra01Recombinant Mineralocorticoid Receptor (MR)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA464Ra01Polyclonal Antibody to Mineralocorticoid Receptor (MR)WB, ICC, IHC-P, IHC-F, ELISA
MAA464Ra21Monoclonal Antibody to Mineralocorticoid Receptor (MR)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA464RaELISA Kit for Mineralocorticoid Receptor (MR)Enzyme-linked immunosorbent assay for Antigen Detection
  1. "Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor."Science 237:268-275(1987) [PubMed] [Europe PMC] [Abstract]
  2. "A new human MR splice variant is a ligand-independent transactivator modulating corticosteroid action."Mol. Endocrinol. 15:1586-1598(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I."Nat. Genet. 19:279-281(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Overexpression and characterization of the human mineralocorticoid receptor."J. Biol. Chem. 266:18072-18081(1991) [PubMed] [Europe PMC] [Abstract]
  7. "Type I pseudohypoaldosteronism includes two clinically and genetically distinct entities with either renal or multiple target organ defects."J. Clin. Endocrinol. Metab. 73:936-944(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of a splice variant of the rat and human mineralocorticoid receptor genes."J. Steroid Biochem. Mol. Biol. 55:159-162(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Tissue-specific expression of alpha and beta messenger ribonucleic acid isoforms of the human mineralocorticoid receptor in normal and pathological states."J. Clin. Endocrinol. Metab. 82:1345-1352(1997) [PubMed] [Europe PMC] [Abstract]
  10. "The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52."Recept. Signal Transduct. 7:85-98(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Cysteines 849 and 942 of human mineralocorticoid receptor are crucial for steroid binding."Biochemistry 37:12153-12159(1998) [PubMed] [Europe PMC] [Abstract]
  12. "Mechanistic aspects of mineralocorticoid receptor activation."Kidney Int. 57:1250-1255(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Crucial role of the H11-H12 loop in stabilizing the active conformation of the human mineralocorticoid receptor."Mol. Endocrinol. 14:1210-1221(2000) [PubMed] [Europe PMC] [Abstract]
  14. "The intracellular localization of the mineralocorticoid receptor is regulated by 11beta-hydroxysteroid dehydrogenase type 2."J. Biol. Chem. 276:28484-28492(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease."Nat. Med. 14:1370-1376(2008) [PubMed] [Europe PMC] [Abstract]
  16. "A ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptor."J. Biol. Chem. 280:31283-31293(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Structural and biochemical mechanisms for the specificity of hormone binding and coactivator assembly by mineralocorticoid receptor."Mol. Cell 19:367-380(2005) [PubMed] [Europe PMC] [Abstract]
  18. "Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension."Nat. Struct. Mol. Biol. 12:554-555(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
  20. "A novel missense mutation of mineralocorticoid receptor gene in one Japanese family with a renal form of pseudohypoaldosteronism type 1."J. Clin. Endocrinol. Metab. 85:4690-4694(2000) [PubMed] [Europe PMC] [Abstract]
  21. "Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy."Science 289:119-123(2000) [PubMed] [Europe PMC] [Abstract]
  22. "Functional polymorphisms in the mineralocorticoid receptor and amirolide-sensitive sodium channel genes in a patient with sporadic pseudohypoaldosteronism."Hum. Genet. 112:91-97(2003) [PubMed] [Europe PMC] [Abstract]
  23. "Different inactivating mutations of the mineralocorticoid receptor in fourteen families affected by type I pseudohypoaldosteronism." J. Clin. Endocrinol. Metab. 88:2508-2517(2003) [PubMed] [Europe PMC] [Abstract]
  24. "Elucidating the underlying molecular pathogenesis of NR3C2 mutants causing autosomal dominant pseudohypoaldosteronism type 1."J. Clin. Endocrinol. Metab. 91:4552-4561(2006) [PubMed] [Europe PMC] [Abstract]
  25. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  26. "Mineralocorticoid receptor mutations are the principal cause of renal type 1 pseudohypoaldosteronism."Hum. Mutat. 28:33-40(2007) [PubMed] [Europe PMC] [Abstract]