Keratin 1 (KRT1)

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CK1; EHK1; K1; KRT1A; KRT1-A; Cytokeratin 1; Epidermolytic Hyperkeratosis; Keratin, type II cytoskeletal 1; 67 kDa cytokeratin; Type-II keratin Kb1

Keratin 1 (KRT1)

The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.Keratin 1 is specifically expressed in the spinous and granular layers of the epidermis with family member keratin 10. Mutations in this gene have been associated with the variants of bullous congenital ichthyosiform erythroderma in which the palms and soles of the feet are affected.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA492Hu01 Recombinant Keratin 1 (KRT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA492Hu01 Polyclonal Antibody to Keratin 1 (KRT1) WB; ICC; IHC-P; IHC-F; ELISA.
MAA492Hu22 Monoclonal Antibody to Keratin 1 (KRT1) WB; IHC; ICC; IP.
LAA492Hu71 Biotin-Linked Polyclonal Antibody to Keratin 1 (KRT1) WB; IHC; ICC.
Assay Kits SEA492Hu ELISA Kit for Keratin 1 (KRT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA492Mu01 Recombinant Keratin 1 (KRT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA492Mu01 Polyclonal Antibody to Keratin 1 (KRT1) WB; IHC; ICC; IP.
LAA492Mu71 Biotin-Linked Polyclonal Antibody to Keratin 1 (KRT1) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Keratin 1 (KRT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Keratin 1 (KRT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA492Ra01 Recombinant Keratin 1 (KRT1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA492Ra02 Recombinant Keratin 1 (KRT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA492Ra01 Polyclonal Antibody to Keratin 1 (KRT1) WB; IHC; ICC; IP.
LAA492Ra71 Biotin-Linked Polyclonal Antibody to Keratin 1 (KRT1) WB; IHC; ICC.
PAA492Ra02 Polyclonal Antibody to Keratin 1 (KRT1) WB; IHC; ICC; IP.
Assay Kits SEA492Ra ELISA Kit for Keratin 1 (KRT1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Genomic organization and amplification of the human epidermal type II keratin genes K1 and K5."Biochem. Biophys. Res. Commun. 274:149-152(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Novel splice site mutation in keratin 1 underlies mild epidermolytic palmoplantar keratoderma in three kindreds."J. Invest. Dermatol. 116:606-609(2001) [PubMed] [Europe PMC] [Abstract]
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