Keratin 1 (KRT1)

[Edit]

CK1; EHK1; K1; KRT1A; KRT1-A; Cytokeratin 1; Epidermolytic Hyperkeratosis; Keratin, type II cytoskeletal 1; 67 kDa cytokeratin; Type-II keratin Kb1

Keratin 1 (KRT1)

The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.Keratin 1 is specifically expressed in the spinous and granular layers of the epidermis with family member keratin 10. Mutations in this gene have been associated with the variants of bullous congenital ichthyosiform erythroderma in which the palms and soles of the feet are affected.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA492Hu01Recombinant Keratin 1 (KRT1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA492Hu01Polyclonal Antibody to Keratin 1 (KRT1)WB, ICC, IHC-P, IHC-F, ELISA
MAA492Hu22Monoclonal Antibody to Keratin 1 (KRT1)WB, ICC, IHC-P, IHC-F, ELISA
LAA492Hu71Biotin-Linked Polyclonal Antibody to Keratin 1 (KRT1)IHC;WB;ELISA
Assay KitsSEA492HuELISA Kit for Keratin 1 (KRT1)Enzyme-linked immunosorbent assay

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA492Mu01Recombinant Keratin 1 (KRT1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA492Mu01Polyclonal Antibody to Keratin 1 (KRT1)WB, ICC, IHC-P, IHC-F, ELISA
LAA492Mu71Biotin-Linked Polyclonal Antibody to Keratin 1 (KRT1)IHC;WB;ELISA
Assay Kitsn/aCLIA Kit for Keratin 1 (KRT1)CLIA Kit Customized Service Offer
n/aELISA Kit for Keratin 1 (KRT1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA492Ra01Recombinant Keratin 1 (KRT1)SDS-PAGE; WB; ELISA; IP.
RPA492Ra02Recombinant Keratin 1 (KRT1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA492Ra01Polyclonal Antibody to Keratin 1 (KRT1)WB, ICC, IHC-P, IHC-F, ELISA
LAA492Ra71Biotin-Linked Polyclonal Antibody to Keratin 1 (KRT1)IHC;WB;ELISA
PAA492Ra02Polyclonal Antibody to Keratin 1 (KRT1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA492RaELISA Kit for Keratin 1 (KRT1)Enzyme-linked immunosorbent assay
  1. "Structure of a gene for the human epidermal 67-kDa keratin."Proc. Natl. Acad. Sci. U.S.A. 82:1896-1900(1985) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization and amplification of the human epidermal type II keratin genes K1 and K5."Biochem. Biophys. Res. Commun. 274:149-152(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Novel splice site mutation in keratin 1 underlies mild epidermolytic palmoplantar keratoderma in three kindreds."J. Invest. Dermatol. 116:606-609(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]