≡

Cytokeratin 14 (CK14)

[Edit]

KRT14; EBS3; EBS4; K14; Keratin 14; Epidermolysis Bullosa Simplex Dowling-Meara Koebner; Keratin, type I cytoskeletal 14

Cytokeratin 14 (CK14)
CCC A522
HGNC 6416
MGI 96688
PubMed 15083518
RGD 1307463
UniProt P02533
Wiki Keratin_14

Keratin 14 is a type I cytokeratin. It is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells.Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex and Dermatopathia pigmentosa reticularis, both of which are autosomal dominant mutations.

KRT14 belongs to a large group of acidic type I keratins that interact with basic type II keratins to form the 8-nm cytoskeletal filaments of epithelial cells. Both type I and type II keratins have a central alpha-helical domain of over 300 amino acids that mediates keratin interaction. KRT14 is expressed in the basal layer of stratified squamous epithelia, including epidermis .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA522Hu01 Recombinant Cytokeratin 14 (CK14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA522Hu01 Polyclonal Antibody to Cytokeratin 14 (CK14) WB; IHC; ICC; IP.
MAA522Hu22 Monoclonal Antibody to Cytokeratin 14 (CK14) WB; IHC; ICC; IP.
Assay Kits SEA522Hu ELISA Kit for Cytokeratin 14 (CK14) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA522Mu01 Recombinant Cytokeratin 14 (CK14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA522Mu01 Polyclonal Antibody to Cytokeratin 14 (CK14) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cytokeratin 14 (CK14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytokeratin 14 (CK14) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA522Ra01 Recombinant Cytokeratin 14 (CK14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA522Ra01 Polyclonal Antibody to Cytokeratin 14 (CK14) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cytokeratin 14 (CK14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytokeratin 14 (CK14) ELISA Kit Customized Service Offer
  1. "Remarkable conservation of structure among intermediate filament genes."Cell 39:491-498(1984) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequence of a gene encoding a human type I keratin: sequences homologous to enhancer elements in the regulatory region of the gene."Proc. Natl. Acad. Sci. U.S.A. 82:1609-1613(1985) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The cDNA sequence of a human epidermal keratin: divergence of sequence but conservation of structure among intermediate filament proteins."Cell 31:243-252(1982) [PubMed] [Europe PMC] [Abstract]
  6. "Genetic analysis of a severe case of Dowling-Meara epidermolysis bullosa simplex."J. Invest. Dermatol. 106:327-334(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: genetic and functional analyses."Cell 66:1301-1311(1991) [PubMed] [Europe PMC] [Abstract]
  8. "A novel mutation of Leu122 to Phe at a highly conserved hydrophobic residue in the helix initiation motif of keratin 14 in epidermolysis bullosa simplex."Hum. Mol. Genet. 3:1171-1172(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle."J. Invest. Dermatol. 110:158-164(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD."J. Cell Biol. 155:415-426(2001) [PubMed] [Europe PMC] [Abstract]
  11. "The nonhelical tail domain of keratin 14 promotes filament bundling and enhances the mechanical properties of keratin intermediate filaments in vitro."J. Cell Biol. 155:747-754(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Structural basis for heteromeric assembly and perinuclear organization of keratin filaments."Nat. Struct. Mol. Biol. 19:707-715(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Epidermolysis bullosa simplex: evidence in two families for keratin gene abnormalities."Science 254:1202-1205(1991) [PubMed] [Europe PMC] [Abstract]
  17. "A novel three-nucleotide deletion in the helix 2B region of keratin 14 in epidermolysis bullosa simplex: delta E375."Hum. Mol. Genet. 2:1971-1972(1993) [PubMed] [Europe PMC] [Abstract]
  18. "A mutation (Met-->Arg) in the type I keratin (K14) gene responsible for autosomal dominant epidermolysis bullosa simplex."Hum. Mutat. 2:37-42(1993) [PubMed] [Europe PMC] [Abstract]
  19. "A keratin 14 mutational hot spot for epidermolysis bullosa simplex, Dowling-Meara: implications for diagnosis."J. Invest. Dermatol. 101:240-243(1993) [PubMed] [Europe PMC] [Abstract]
  20. "A missense mutation in the rod domain of keratin 14 associated with recessive epidermolysis bullosa simplex."Nat. Genet. 3:327-331(1993) [PubMed] [Europe PMC] [Abstract]
  21. "Missing links: Weber-Cockayne keratin mutations implicate the L12 linker domain in effective cytoskeleton function."Nat. Genet. 5:294-300(1993) [PubMed] [Europe PMC] [Abstract]
  22. "Keratin 14 gene mutations in patients with epidermolysis bullosa simplex."J. Invest. Dermatol. 105:629-632(1995) [PubMed] [Europe PMC] [Abstract]
  23. "Partial dominance of a keratin 14 mutation in epidermolysis bullosa simplex: increased severity of disease in a homozygote."J. Invest. Dermatol. 109:360-364(1997) [PubMed] [Europe PMC] [Abstract]
  24. "Severe palmo-plantar hyperkeratosis in Dowling-Meara epidermolysis bullosa simplex caused by a mutation in the keratin 14 gene (KRT14)."J. Invest. Dermatol. 111:893-895(1998) [PubMed] [Europe PMC] [Abstract]
  25. "Novel K5 and K14 mutations in German patients with the Weber-Cockayne variant of epidermolysis bullosa simplex."J. Invest. Dermatol. 111:900-902(1998) [PubMed] [Europe PMC] [Abstract]
  26. "A recurrent keratin 14 mutation in Dowling-Meara epidermolysis bullosa simplex."Br. J. Dermatol. 141:747-748(1999) [PubMed] [Europe PMC] [Abstract]
  27. "Genomic keratin 14 mutation detection in epidermolysis bullosa simplex."Eur. J. Hum. Genet. Suppl. 7:121-121(1999)
  28. "Identification of novel and known mutations in the genes for keratin 5 and 14 in Danish patients with epidermolysis bullosa simplex: correlation between genotype and phenotype."J. Invest. Dermatol. 112:184-190(1999) [PubMed] [Europe PMC] [Abstract]
  29. "Laryngeal involvement in the Dowling-Meara variant of epidermolysis bullosa simplex with keratin mutations of severely disruptive potential."Br. J. Dermatol. 142:315-320(2000) [PubMed] [Europe PMC] [Abstract]
  30. "Exempting homologous pseudogene sequences from polymerase chain reaction amplification allows genomic keratin 14 hotspot analysis."J. Invest. Dermatol. 114:616-619(2000) [PubMed] [Europe PMC] [Abstract]
  31. "DNA based prenatal testing for the skin blistering disorder epidermolysis bullosa simplex."Prenat. Diagn. 20:371-377(2000) [PubMed] [Europe PMC] [Abstract]
  32. "Keratin 14 point mutations at codon 119 of helix 1A resulting in different epidermolysis bullosa simplex phenotypes."J. Invest. Dermatol. 117:1103-1107(2001) [PubMed] [Europe PMC] [Abstract]
  33. "Epidermolysis bullosa simplex in Israel: clinical and genetic features."Arch. Dermatol. 139:498-505(2003) [PubMed] [Europe PMC] [Abstract]
  34. ErratumArch. Dermatol. 139:1084-1084(2003)
  35. "Mutation analysis of the entire keratin 5 and 14 genes in patients with epidermolysis bullosa simplex and identification of novel mutations."Hum. Mutat. 21:447-447(2003) [PubMed] [Europe PMC] [Abstract]
  36. "Long-range polymerase chain reaction for specific full-length amplification of the human keratin 14 gene and novel keratin 14 mutations in epidermolysis bullosa simplex patients."J. Invest. Dermatol. 120:495-497(2003) [PubMed] [Europe PMC] [Abstract]
  37. "Novel keratin 14 gene mutations in patients from Hungary with epidermolysis bullosa simplex."Exp. Dermatol. 13:185-191(2004) [PubMed] [Europe PMC] [Abstract]
  38. "Naegeli-Franceschetti-Jadassohn syndrome and dermatopathia pigmentosa reticularis: two allelic ectodermal dysplasias caused by dominant mutations in KRT14."Am. J. Hum. Genet. 79:724-730(2006) [PubMed] [Europe PMC] [Abstract]
  39. "Epidermolysis bullosa simplex in Japanese and Korean patients: genetic studies in 19 cases."Br. J. Dermatol. 155:313-317(2006) [PubMed] [Europe PMC] [Abstract]
  40. "Novel and recurrent mutations in keratin KRT5 and KRT14 genes in epidermolysis bullosa simplex: implications for disease phenotype and keratin filament assembly."Hum. Mutat. 27:719-720(2006) [PubMed] [Europe PMC] [Abstract]
  41. "Novel KRT14 mutation causing epidermolysis bullosa simplex with variable phenotype."Exp. Dermatol. 23:684-687(2014) [PubMed] [Europe PMC] [Abstract]