Interleukin 1 Beta (IL1b)

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IL1-B; IL1-Beta; IL1F2; IL-1β; Interleukin-1 Family Member 2; Catabolin

Interleukin 1 Beta (IL1b)

Interleukin-1 (IL-1) is one of the first cytokines ever described. Its initial discovery was as a factor that could induce fever, control lymphocytes, increase the number of bone marrow cells and cause degeneration of bone joints. At this time, IL-1 was known under several other names including endogenous pyrogen, lymphocyte activating factor, haemopoetin-1 and mononuclear cell factor, amongst others.

It was around 1984-1985 when scientists confirmed that IL-1 was actually composed of two distinct proteins, now called IL-1α and IL-1β.These belong to a family of cytokines known as the interleukin-1 superfamily.Both IL-1α and IL-1β are produced by macrophages, monocytes and dendritic cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA563Hu01 Recombinant Interleukin 1 Beta (IL1b) Positive Control; Immunogen; SDS-PAGE; WB.
EPA563Hu61 Eukaryotic Interleukin 1 Beta (IL1b) Positive Control; Immunogen; SDS-PAGE; WB.
APA563Hu61 Active Interleukin 1 Beta (IL1b) Cell culture; Activity Assays.
APA563Hu01 Active Interleukin 1 Beta (IL1b) Cell culture; Activity Assays.
Antibodies PAA563Hu01 Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
MAA563Hu22 Monoclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
PAA563Hu06 Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
MAA563Hu21 Monoclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
Assay Kits SEA563Hu ELISA Kit for Interleukin 1 Beta (IL1b) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA563Hu CLIA Kit for Interleukin 1 Beta (IL1b) Chemiluminescent immunoassay for Antigen Detection.
HEA563Hu High Sensitive ELISA Kit for Interleukin 1 Beta (IL1b) Enzyme-linked immunosorbent assay for Antigen Detection.
AEA563Hu ELISA Kit for Anti-Interleukin 1 Beta Antibody (Anti-IL1b) Enzyme-linked immunosorbent assay for Antibody Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA563Mu01 Recombinant Interleukin 1 Beta (IL1b) Positive Control; Immunogen; SDS-PAGE; WB.
RPA563Mu02 Recombinant Interleukin 1 Beta (IL1b) Positive Control; Immunogen; SDS-PAGE; WB.
CPA563Mu11 BSA Conjugated Interleukin 1 Beta (IL1b) Immunogen; SDS-PAGE; WB.
CPA563Mu21 OVA Conjugated Interleukin 1 Beta (IL1b) Immunogen; SDS-PAGE; WB.
EPA563Mu61 Eukaryotic Interleukin 1 Beta (IL1b) Positive Control; Immunogen; SDS-PAGE; WB.
APA563Mu61 Active Interleukin 1 Beta (IL1b) Cell culture; Activity Assays.
APA563Mu02 Active Interleukin 1 Beta (IL1b) Cell culture; Activity Assays.
Antibodies PAA563Mu01 Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
LAA563Mu71 Biotin-Linked Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC.
PAA563Mu02 Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
MAA563Mu21 Monoclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
PAA563Mu08 Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
MAA563Mu22 Monoclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
Assay Kits SEA563Mu ELISA Kit for Interleukin 1 Beta (IL1b) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA563Mu CLIA Kit for Interleukin 1 Beta (IL1b) Chemiluminescent immunoassay for Antigen Detection.
HEA563Mu High Sensitive ELISA Kit for Interleukin 1 Beta (IL1b) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA563Ra01 Recombinant Interleukin 1 Beta (IL1b) Positive Control; Immunogen; SDS-PAGE; WB.
CPA563Ra11 BSA Conjugated Interleukin 1 Beta (IL1b) Immunogen; SDS-PAGE; WB.
CPA563Ra21 OVA Conjugated Interleukin 1 Beta (IL1b) Immunogen; SDS-PAGE; WB.
APA563Ra01 Active Interleukin 1 Beta (IL1b) Cell culture; Activity Assays.
APA563Ra61 Active Interleukin 1 Beta (IL1b) Cell culture; Activity Assays.
EPA563Ra61 Eukaryotic Interleukin 1 Beta (IL1b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA563Ra01 Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
LAA563Ra71 Biotin-Linked Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC.
LAA563Ra81 FITC-Linked Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IF.
MAA563Ra21 Monoclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
PAA563Ra08 Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
Assay Kits SEA563Ra ELISA Kit for Interleukin 1 Beta (IL1b) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA563Ra CLIA Kit for Interleukin 1 Beta (IL1b) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Cavia (Guinea pig )

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA563Gu01 Recombinant Interleukin 1 Beta (IL1b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA563Gu01 Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
LAA563Gu71 Biotin-Linked Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC.
LAA563Gu81 FITC-Linked Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IF.
MAA563Gu21 Monoclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
Assay Kits SEA563Gu ELISA Kit for Interleukin 1 Beta (IL1b) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA563Rb01 Recombinant Interleukin 1 Beta (IL1b) Positive Control; Immunogen; SDS-PAGE; WB.
RPA563Rb02 Recombinant Interleukin 1 Beta (IL1b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA563Rb52 Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
PAA563Rb51 Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
LAA563Rb71 Biotin-Linked Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC.
MAA563Rb21 Monoclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
Assay Kits SEA563Rb ELISA Kit for Interleukin 1 Beta (IL1b) Enzyme-linked immunosorbent assay for Antigen Detection.
HEA563Rb High Sensitive ELISA Kit for Interleukin 1 Beta (IL1b) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA563Si01 Recombinant Interleukin 1 Beta (IL1b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA563Si01 Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
MAA563Si21 Monoclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
Assay Kits SEA563Si ELISA Kit for Interleukin 1 Beta (IL1b) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA563Ca01 Recombinant Interleukin 1 Beta (IL1b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA563Ca01 Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
MAA563Ca21 Monoclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
LAA563Ca72 Biotin-Linked Monoclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC.
Assay Kits SEA563Ca ELISA Kit for Interleukin 1 Beta (IL1b) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA563Po01 Recombinant Interleukin 1 Beta (IL1b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA563Po01 Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
MAA563Po21 Monoclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
MAA563Po26 Monoclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
LAA563Po76 Biotin-Linked Monoclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC.
Assay Kits SEA563Po ELISA Kit for Interleukin 1 Beta (IL1b) Enzyme-linked immunosorbent assay for Antigen Detection.
HEA563Po High Sensitive ELISA Kit for Interleukin 1 Beta (IL1b) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA563Bo01 Recombinant Interleukin 1 Beta (IL1b) Positive Control; Immunogen; SDS-PAGE; WB.
RPA563Bo02 Recombinant Interleukin 1 Beta (IL1b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA563Bo01 Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
MAA563Bo21 Monoclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
PAA563Bo02 Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
Assay Kits SEA563Bo ELISA Kit for Interleukin 1 Beta (IL1b) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA563Ov01 Recombinant Interleukin 1 Beta (IL1b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA563Ov01 Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
MAA563Ov21 Monoclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
Assay Kits SEA563Ov ELISA Kit for Interleukin 1 Beta (IL1b) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA563Eq01 Recombinant Interleukin 1 Beta (IL1b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA563Eq01 Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
LAA563Eq71 Biotin-Linked Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC.
MAA563Eq21 Monoclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
Assay Kits SEA563Eq ELISA Kit for Interleukin 1 Beta (IL1b) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA563Ga01 Recombinant Interleukin 1 Beta (IL1b) Positive Control; Immunogen; SDS-PAGE; WB.
RPA563Ga02 Recombinant Interleukin 1 Beta (IL1b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA563Ga01 Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
MAA563Ga21 Monoclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
PAA563Ga02 Polyclonal Antibody to Interleukin 1 Beta (IL1b) WB; IHC; ICC; IP.
Assay Kits SEA563Ga ELISA Kit for Interleukin 1 Beta (IL1b) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Danio rerio (Zebrafish)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA563Fi01 Recombinant Interleukin 1 Beta (IL1b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Interleukin 1 Beta (IL1b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 1 Beta (IL1b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin 1 Beta (IL1b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 1 Beta (IL1b) ELISA Kit Customized Service Offer
  1. "Nucleotide sequence of human monocyte interleukin 1 precursor cDNA."Proc. Natl. Acad. Sci. U.S.A. 81:7907-7911(1984) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs."Nature 315:641-647(1985) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene."Nucleic Acids Res. 14:7897-7914(1986) [PubMed] [Europe PMC] [Abstract]
  4. ErratumNucleic Acids Res. 15:868-868(1987)
  5. "cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line."Biochem. Biophys. Res. Commun. 143:345-352(1987) [PubMed] [Europe PMC] [Abstract]
  6. "Human interleukin-1 beta gene."Gene 52:95-101(1987) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning of the cDNA coding for human prointerleukin-1 alpha and prointerleukin-1 beta."Dokl. Akad. Nauk SSSR 309:1005-1008(1989) [PubMed] [Europe PMC] [Abstract]
  8. "A sequence-based map of the nine genes of the human interleukin-1 cluster."Genomics 79:718-725(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase."J. Exp. Med. 174:821-825(1991) [PubMed] [Europe PMC] [Abstract]
  12. "Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1."Nature 314:266-268(1985) [PubMed] [Europe PMC] [Abstract]
  13. "Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow."Blood 71:962-968(1988) [PubMed] [Europe PMC] [Abstract]
  14. "The role of arginine residues in interleukin 1 receptor binding."Biochim. Biophys. Acta 1118:25-35(1991) [PubMed] [Europe PMC] [Abstract]
  15. "The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing."Cell Death Differ. 14:1457-1466(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Crystal structure of the cytokine interleukin-1 beta."EMBO J. 7:339-343(1988) [PubMed] [Europe PMC] [Abstract]
  17. "Crystal structure of recombinant human interleukin-1 beta at 2.0-A resolution."J. Mol. Biol. 209:779-791(1989) [PubMed] [Europe PMC] [Abstract]
  18. "Crystallographic refinement of interleukin 1 beta at 2.0-A resolution."Proc. Natl. Acad. Sci. U.S.A. 86:9667-9671(1989) [PubMed] [Europe PMC] [Abstract]
  19. "Determination of the secondary structure and molecular topology of interleukin-1 beta by use of two- and three-dimensional heteronuclear 15N-1H NMR spectroscopy."Biochemistry 29:4668-4682(1990) [PubMed] [Europe PMC] [Abstract]
  20. "High-resolution three-dimensional structure of interleukin 1 beta in solution by three- and four-dimensional nuclear magnetic resonance spectroscopy."Biochemistry 30:2315-2323(1991) [PubMed] [Europe PMC] [Abstract]
  21. "Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta."Nature 386:190-194(1997) [PubMed] [Europe PMC] [Abstract]
  22. "Structural insights into the assembly and activation of IL-1beta with its receptors."Nat. Immunol. 11:905-911(2010) [PubMed] [Europe PMC] [Abstract]