Interleukin 1 Beta (IL1b)
[Edit]IL1-B; IL1-Beta; IL1F2; IL-1β; Interleukin-1 Family Member 2; Catabolin
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Interleukin-1 (IL-1) is one of the first cytokines ever described. Its initial discovery was as a factor that could induce fever, control lymphocytes, increase the number of bone marrow cells and cause degeneration of bone joints. At this time, IL-1 was known under several other names including endogenous pyrogen, lymphocyte activating factor, haemopoetin-1 and mononuclear cell factor, amongst others.
It was around 1984-1985 when scientists confirmed that IL-1 was actually composed of two distinct proteins, now called IL-1α and IL-1β.These belong to a family of cytokines known as the interleukin-1 superfamily.Both IL-1α and IL-1β are produced by macrophages, monocytes and dendritic cells.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA563Hu01 | Recombinant Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| EPA563Hu61 | Eukaryotic Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA563Hu61 | Active Interleukin 1 Beta (IL1b) | Cell culture; Activity Assays. | |
| APA563Hu01 | Active Interleukin 1 Beta (IL1b) | Cell culture; Activity Assays. | |
| Antibodies | PAA563Hu01 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. |
| MAA563Hu22 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB | |
| PAA563Hu06 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| MAA563Hu21 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| MAA563Hu23 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| MAA563Hu24 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| MAA563Hu25 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| MAA563Hu26 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA563Hu | ELISA Kit for Interleukin 1 Beta (IL1b) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA563Hu | CLIA Kit for Interleukin 1 Beta (IL1b) | Chemiluminescent immunoassay for Antigen Detection. | |
| HEA563Hu | High Sensitive ELISA Kit for Interleukin 1 Beta (IL1b) | Enzyme-linked immunosorbent assay for Antigen Detection. | |
| AEA563Hu | ELISA Kit for Anti-Interleukin 1 Beta Antibody (Anti-IL1b) | Enzyme-linked immunosorbent assay for Antibody Detection. | |
| IEA563Hu | Instant ELISA Kit for Interleukin 1 Beta (IL1b) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA563Mu01 | Recombinant Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA563Mu02 | Recombinant Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| CPA563Mu11 | BSA Conjugated Interleukin 1 Beta (IL1b) | Immunogen; SDS-PAGE; WB. | |
| CPA563Mu21 | OVA Conjugated Interleukin 1 Beta (IL1b) | Immunogen; SDS-PAGE; WB. | |
| EPA563Mu61 | Eukaryotic Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA563Mu61 | Active Interleukin 1 Beta (IL1b) | Cell culture; Activity Assays. | |
| APA563Mu02 | Active Interleukin 1 Beta (IL1b) | Cell culture; Activity Assays. | |
| APA563Mu01 | Active Interleukin 1 Beta (IL1b) | Cell culture; Activity Assays. | |
| Antibodies | PAA563Mu01 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB |
| LAA563Mu71 | Biotin-Linked Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC. | |
| PAA563Mu02 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| MAA563Mu21 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| PAA563Mu08 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| MAA563Mu22 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| MAA563Mu23 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| MAA563Mu24 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| MAA563Mu26 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| PAA563Mu06 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA563Mu | ELISA Kit for Interleukin 1 Beta (IL1b) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA563Mu | CLIA Kit for Interleukin 1 Beta (IL1b) | Chemiluminescent immunoassay for Antigen Detection. | |
| HEA563Mu | High Sensitive ELISA Kit for Interleukin 1 Beta (IL1b) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
Organism species: Cavia (Guinea pig )
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA563Gu01 | Recombinant Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA563Gu01 | Active Interleukin 1 Beta (IL1b) | Cell culture; Activity Assays. | |
| Antibodies | PAA563Gu01 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. |
| LAA563Gu71 | Biotin-Linked Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC. | |
| LAA563Gu81 | FITC-Linked Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IF. | |
| MAA563Gu21 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA563Gu | ELISA Kit for Interleukin 1 Beta (IL1b) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
Organism species: Rhesus monkey (Simian)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA563Si01 | Recombinant Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA563Si01 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. |
| MAA563Si21 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA563Si | ELISA Kit for Interleukin 1 Beta (IL1b) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Canis familiaris; Canine (Dog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA563Ca01 | Recombinant Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA563Ca01 | Active Interleukin 1 Beta (IL1b) | Cell culture; Activity Assays. | |
| Antibodies | PAA563Ca01 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. |
| MAA563Ca21 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| LAA563Ca72 | Biotin-Linked Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC. | |
| Assay Kits | SEA563Ca | ELISA Kit for Interleukin 1 Beta (IL1b) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA563Po01 | Recombinant Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA563Po01 | Active Interleukin 1 Beta (IL1b) | Cell culture; Activity Assays. | |
| Antibodies | PAA563Po01 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. |
| MAA563Po21 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| MAA563Po26 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| LAA563Po76 | Biotin-Linked Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC. | |
| MAA563Po22 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| MAA563Po23 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA563Po | ELISA Kit for Interleukin 1 Beta (IL1b) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| HEA563Po | High Sensitive ELISA Kit for Interleukin 1 Beta (IL1b) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA563Bo01 | Recombinant Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA563Bo02 | Recombinant Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA563Bo01 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. |
| MAA563Bo21 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| PAA563Bo02 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA563Bo | ELISA Kit for Interleukin 1 Beta (IL1b) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Ovis aries; Ovine (Sheep)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA563Ov01 | Recombinant Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA563Ov01 | Active Interleukin 1 Beta (IL1b) | Cell culture; Activity Assays. | |
| Antibodies | PAA563Ov01 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. |
| MAA563Ov21 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA563Ov | ELISA Kit for Interleukin 1 Beta (IL1b) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Equus caballus; Equine (Horse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA563Eq01 | Recombinant Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA563Eq01 | Active Interleukin 1 Beta (IL1b) | Cell culture; Activity Assays. | |
| Antibodies | PAA563Eq01 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. |
| LAA563Eq71 | Biotin-Linked Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC. | |
| MAA563Eq21 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA563Eq | ELISA Kit for Interleukin 1 Beta (IL1b) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Chicken (Gallus)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA563Ga01 | Recombinant Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA563Ga02 | Recombinant Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA563Ga01 | Active Interleukin 1 Beta (IL1b) | Cell culture; Activity Assays. | |
| APA563Ga02 | Active Interleukin 1 Beta (IL1b) | Cell culture; Activity Assays. | |
| Antibodies | PAA563Ga01 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. |
| MAA563Ga21 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| PAA563Ga02 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA563Ga | ELISA Kit for Interleukin 1 Beta (IL1b) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Danio rerio (Zebrafish)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA563Fi01 | Recombinant Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA563Fi01 | Active Interleukin 1 Beta (IL1b) | Cell culture; Activity Assays. | |
| Antibodies | PAA563Fi01 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Interleukin 1 Beta (IL1b) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Interleukin 1 Beta (IL1b) | ELISA Kit Customized Service Offer |
- "Nucleotide sequence of human monocyte interleukin 1 precursor cDNA."Proc. Natl. Acad. Sci. U.S.A. 81:7907-7911(1984) [PubMed] [Europe PMC] [Abstract]
- "Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs."Nature 315:641-647(1985) [PubMed] [Europe PMC] [Abstract]
- "Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene."Nucleic Acids Res. 14:7897-7914(1986) [PubMed] [Europe PMC] [Abstract]
- ErratumNucleic Acids Res. 15:868-868(1987)
- "cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line."Biochem. Biophys. Res. Commun. 143:345-352(1987) [PubMed] [Europe PMC] [Abstract]
- "Human interleukin-1 beta gene."Gene 52:95-101(1987) [PubMed] [Europe PMC] [Abstract]
- "Cloning of the cDNA coding for human prointerleukin-1 alpha and prointerleukin-1 beta."Dokl. Akad. Nauk SSSR 309:1005-1008(1989) [PubMed] [Europe PMC] [Abstract]
- "A sequence-based map of the nine genes of the human interleukin-1 cluster."Genomics 79:718-725(2002) [PubMed] [Europe PMC] [Abstract]
- "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase."J. Exp. Med. 174:821-825(1991) [PubMed] [Europe PMC] [Abstract]
- "Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1."Nature 314:266-268(1985) [PubMed] [Europe PMC] [Abstract]
- "Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow."Blood 71:962-968(1988) [PubMed] [Europe PMC] [Abstract]
- "The role of arginine residues in interleukin 1 receptor binding."Biochim. Biophys. Acta 1118:25-35(1991) [PubMed] [Europe PMC] [Abstract]
- "The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing."Cell Death Differ. 14:1457-1466(2007) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of the cytokine interleukin-1 beta."EMBO J. 7:339-343(1988) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of recombinant human interleukin-1 beta at 2.0-A resolution."J. Mol. Biol. 209:779-791(1989) [PubMed] [Europe PMC] [Abstract]
- "Crystallographic refinement of interleukin 1 beta at 2.0-A resolution."Proc. Natl. Acad. Sci. U.S.A. 86:9667-9671(1989) [PubMed] [Europe PMC] [Abstract]
- "Determination of the secondary structure and molecular topology of interleukin-1 beta by use of two- and three-dimensional heteronuclear 15N-1H NMR spectroscopy."Biochemistry 29:4668-4682(1990) [PubMed] [Europe PMC] [Abstract]
- "High-resolution three-dimensional structure of interleukin 1 beta in solution by three- and four-dimensional nuclear magnetic resonance spectroscopy."Biochemistry 30:2315-2323(1991) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta."Nature 386:190-194(1997) [PubMed] [Europe PMC] [Abstract]
- "Structural insights into the assembly and activation of IL-1beta with its receptors."Nat. Immunol. 11:905-911(2010) [PubMed] [Europe PMC] [Abstract]