Aquaporin 1, Colton Blood Group (AQP1)

[Edit]

AQP-CHIP; CHIP28; CO; Channel-Forming Integral Protein,28kDa; Aquaporin-CHIP; Urine water channel; Water channel protein for red blood cells and kidney proximal tubule

Aquaporin 1, Colton Blood Group (AQP1)

AQP1 is a polypeptide hormone produced in pancreatic beta-cells that belongs to the family of calcitonin gene-related peptides. There is a 20% sequence homology between AQP1 and calcitonin and 44% homology with calcitonin gene-related peptide. AQP1 and its fragments stimulate the proliferation of osteoblasts, inhibit bone resorption, and increase bone density and the amount of bone mass.Analysis of the deduced amino acid sequence suggested that CHIP28 protein contains 6 bilayer-spanning domains, 2 exofacial potential N-glycosylation sites, and intracellular N and C termini. The sequence showed strong homology with the major intrinsic protein of bovine lens (MIP26), which is the prototype of an ancient family of membrane channels.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA579Hu01Recombinant Aquaporin 1, Colton Blood Group (AQP1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA579Hu01Polyclonal Antibody to Aquaporin 1, Colton Blood Group (AQP1)WB, ICC, IHC-P, IHC-F, ELISA
MAA579Hu22Monoclonal Antibody to Aquaporin 1, Colton Blood Group (AQP1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA579HuELISA Kit for Aquaporin 1, Colton Blood Group (AQP1)Enzyme-linked immunosorbent assay

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Aquaporin 1, Colton Blood Group (AQP1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Aquaporin 1, Colton Blood Group (AQP1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Aquaporin 1, Colton Blood Group (AQP1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Aquaporin 1, Colton Blood Group (AQP1)CLIA Kit Customized Service Offer
n/aELISA Kit for Aquaporin 1, Colton Blood Group (AQP1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Aquaporin 1, Colton Blood Group (AQP1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Aquaporin 1, Colton Blood Group (AQP1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Aquaporin 1, Colton Blood Group (AQP1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Aquaporin 1, Colton Blood Group (AQP1)CLIA Kit Customized Service Offer
n/aELISA Kit for Aquaporin 1, Colton Blood Group (AQP1)ELISA Kit Customized Service Offer
  1. "Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family."Proc. Natl. Acad. Sci. U.S.A. 88:11110-11114(1991) [PubMed] [Europe PMC] [Abstract]
  2. "The human aquaporin-CHIP gene. Structure, organization, and chromosomal localization."J. Biol. Chem. 268:15772-15778(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of the 3' UTR sequence encoded by the AQP-1 gene in human retinal pigment epithelium."Biochim. Biophys. Acta 1282:174-178(1996) [PubMed] [Europe PMC] [Abstract]
  4. "The water channel gene in human uterus."Biochem. Mol. Biol. Int. 32:371-377(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Erythrocyte Mr 28,000 transmembrane protein exists as a multisubunit oligomer similar to channel proteins."J. Biol. Chem. 266:6407-6415(1991) [PubMed] [Europe PMC] [Abstract]
  10. "Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein."Science 256:385-387(1992) [PubMed] [Europe PMC] [Abstract]
  11. "The mercury-sensitive residue at cysteine 189 in the CHIP28 water channel."J. Biol. Chem. 268:17-20(1993) [PubMed] [Europe PMC] [Abstract]
  12. "Membrane topology of aquaporin CHIP. Analysis of functional epitope-scanning mutants by vectorial proteolysis."J. Biol. Chem. 269:1668-1673(1994) [PubMed] [Europe PMC] [Abstract]
  13. "Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains."Biochim. Biophys. Acta 1828:956-966(2013) [PubMed] [Europe PMC] [Abstract]
  14. "The three-dimensional structure of human erythrocyte aquaporin CHIP."EMBO J. 13:2985-2993(1994) [PubMed] [Europe PMC] [Abstract]
  15. "The three-dimensional structure of aquaporin-1."Nature 387:624-627(1997) [PubMed] [Europe PMC] [Abstract]
  16. "Structural determinants of water permeation through aquaporin-1."Nature 407:599-605(2000) [PubMed] [Europe PMC] [Abstract]
  17. "A refined structure of human aquaporin-1."FEBS Lett. 504:206-211(2001) [PubMed] [Europe PMC] [Abstract]
  18. "Visualization of a water-selective pore by electron crystallography in vitreous ice."Proc. Natl. Acad. Sci. U.S.A. 98:1398-1403(2001) [PubMed] [Europe PMC] [Abstract]
  19. "Human red cell aquaporin CHIP. I. Molecular characterization of ABH and Colton blood group antigens."J. Clin. Invest. 94:1043-1049(1994) [PubMed] [Europe PMC] [Abstract]
  20. "Mutations in aquaporin-1 in phenotypically normal humans without functional CHIP water channels."Science 265:1585-1587(1994) [PubMed] [Europe PMC] [Abstract]