Complement Factor H (CFH)

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CF-H; FH; FHL1; ARMD4; ARMS1; CFHL3; HF1; HF2; HUS; H Factor 2; Age-Related Maculopathy Susceptibility 1; Adrenomedullin binding protein

Complement Factor H (CFH)

Factor H is a member of the regulators of complement activation family and is a complement control protein. It is a large (155 kilodaltons), soluble glycoprotein that circulates in human plasma (at a concentration of 500–800 micrograms per milliliter). Its main job is to regulate the Alternative Pathway of the complement system, ensuring that the complement system is directed towards pathogens and does not damage host tissue. Factor H regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3 convertase, C3bBb. Factor H protects self cells from complement activation but not bacteria/viruses, in that it binds to glycosaminoglycans (GAGs) that are present on host cells but not pathogen cell surfaces.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA635Hu01Recombinant Complement Factor H (CFH)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA635Hu01Polyclonal Antibody to Complement Factor H (CFH)WB, ICC, IHC-P, IHC-F, ELISA
MAA635Hu22Monoclonal Antibody to Complement Factor H (CFH)WB, ICC, IHC-P, IHC-F, ELISA
LAA635Hu71Biotin-Linked Polyclonal Antibody to Complement Factor H (CFH)IHC;WB;ELISA
LAA635Hu81FITC-Linked Polyclonal Antibody to Complement Factor H (CFH)IHC;ICC;IF;WB
Assay KitsSEA635HuELISA Kit for Complement Factor H (CFH)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA635Mu01Recombinant Complement Factor H (CFH)SDS-PAGE; WB; ELISA; IP.
RPA635Mu02Recombinant Complement Factor H (CFH)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA635Mu01Polyclonal Antibody to Complement Factor H (CFH)WB, ICC, IHC-P, IHC-F, ELISA
PAA635Mu02Polyclonal Antibody to Complement Factor H (CFH)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA635MuELISA Kit for Complement Factor H (CFH)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA635Ra01Recombinant Complement Factor H (CFH)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA635Ra01Polyclonal Antibody to Complement Factor H (CFH)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
MAA635Ra21Monoclonal Antibody to Complement Factor H (CFH)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
Assay KitsCEA635RaELISA Kit for Complement Factor H (CFH)Enzyme-linked immunosorbent assay for Antigen Detection
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  8. Thesis (1993), Hospital Trias I Pujol, Spain
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  32. "Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration."Am. J. Hum. Genet. 77:149-153(2005) [PubMed] [Europe PMC] [Abstract]
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