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Cluster Of Differentiation 28 (CD28)

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Tp44; T-Cell-Specific Surface Glycoprotein

Cluster Of Differentiation 28 (CD28)
CCC A652
HGNC 1653
MGI 88327
PubMed 11244036
RGD 2299
UniProt P10747
Wiki CD28
The cluster of differentiation (CD) antigen CD28 is a 44kDa, disulphide-bonded, homodimeric glycoprotein, which is constitutively expressed on the surface of the majority of T-cells.CD28 is structurally very closely related to another molecule expressed in activated T-cells, CTLA-4. In particular, the hinge region is completely conserved for both molecules. Also CTLA-4 and CD28 were shown to be very similar at the message and at the gene structure level. The corresponding genes co-map on human chromosome 2q33.Ligation of CD28 by its counter receptor, B7, expressed on the surface of antigen presenting cells, has been shown to induce signals that, in synergy with those derived from engagement of the T-cell receptor by an antigen bound to a major histocompatibilty complex, enhance proliferation and cytokine production.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins EPA652Hu61 Eukaryotic Cluster Of Differentiation 28 (CD28) Positive Control; Immunogen; SDS-PAGE; WB.
EPA652Hu62 Eukaryotic Cluster Of Differentiation 28 (CD28) Positive Control; Immunogen; SDS-PAGE; WB.
APA652Hu61 Active Cluster Of Differentiation 28 (CD28) Cell culture; Activity Assays.
Antibodies MAA652Hu26 Monoclonal Antibody to Cluster Of Differentiation 28 (CD28) WB; IHC; ICC; IP.
MAA652Hu21 Monoclonal Antibody to Cluster Of Differentiation 28 (CD28) WB; IHC; ICC; IP.
MAA652Hu22 Monoclonal Antibody to Cluster Of Differentiation 28 (CD28) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 28 (CD28) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 28 (CD28) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA652Mu01 Recombinant Cluster Of Differentiation 28 (CD28) Positive Control; Immunogen; SDS-PAGE; WB.
RPA652Mu02 Recombinant Cluster Of Differentiation 28 (CD28) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA652Mu01 Polyclonal Antibody to Cluster Of Differentiation 28 (CD28) WB; IHC; ICC; IP.
PAA652Mu02 Polyclonal Antibody to Cluster Of Differentiation 28 (CD28) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 28 (CD28) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 28 (CD28) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA652Ra01 Recombinant Cluster Of Differentiation 28 (CD28) Positive Control; Immunogen; SDS-PAGE; WB.
APA652Ra01 Active Cluster Of Differentiation 28 (CD28) Cell culture; Activity Assays.
Antibodies PAA652Ra01 Polyclonal Antibody to Cluster Of Differentiation 28 (CD28) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 28 (CD28) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 28 (CD28) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system."Proc. Natl. Acad. Sci. U.S.A. 84:8573-8577(1987) [PubMed] [Europe PMC] [Abstract]
  2. "The genomic organization of the CD28 gene. Implications for the regulation of CD28 mRNA expression and heterogeneity."J. Immunol. 145:344-352(1990) [PubMed] [Europe PMC] [Abstract]
  3. "A novel CD28 mRNA variant and simultaneous presence of various CD28 mRNA isoforms in human T lymphocytes."Hum. Immunol. 63:20-23(2002) [PubMed] [Europe PMC] [Abstract]
  4. "A novel costimulatory signaling in human T lymphocytes by a splice variant of CD28."Blood 99:2138-2145(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches."Genomics 78:155-168(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of a soluble CD28-Fab complex."Nat. Immunol. 6:271-279(2005) [PubMed] [Europe PMC] [Abstract]
  13. "High resolution crystal structure of the Grb2 SH2 domain with a phosphopeptide derived from CD28."PLoS ONE 8:E74482-E74482(2013) [PubMed] [Europe PMC] [Abstract]