Glucokinase (GCK)


GK; GLK; HHF3; HK4; HKIV; HXKP; MODY2; Hexokinase-D; Hexokinase 4; Maturity Onset Diabetes Of The Young 2

Glucokinase (GCK)

Glucokinase (GK) is a hexokinase isozyme, related homologously and by evolution to at least three other hexokinases. All of the hexokinases can mediate phosphorylation of glucose to glucose-6-phosphate (G6P), which is the first step of both glycogen synthesis and glycolysis. However, glucokinase is coded by a separate gene and its distinctive kinetic properties allow it to serve a different set of functions. Glucokinase has a lower affinity for glucose than the other hexokinases do, and its activity is localized to a few cell types, leaving the other three hexokinases as more important preparers of glucose for glycolysis and glycogen synthesis for most tissues and organs. Because of this reduced affinity, the activity of glucokinase, under usual physiological conditions, varies substantially according to the concentration of glucose.

Organism species: Homo sapiens (Human)

ProteinsRPA667Hu01Recombinant Glucokinase (GCK)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAA667Hu01Polyclonal Antibody to Glucokinase (GCK)WB; IHC; ICC; IP.
MAA667Hu22Monoclonal Antibody to Glucokinase (GCK)WB; IHC; ICC; IP.
LAA667Hu71Biotin-Linked Polyclonal Antibody to Glucokinase (GCK)WB; IHC; ICC.
Assay KitsSEA667HuELISA Kit for Glucokinase (GCK)Enzyme-linked immunosorbent assay for Antigen Detection.
SCA667HuCLIA Kit for Glucokinase (GCK)Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

ProteinsRPA667Mu01Recombinant Glucokinase (GCK)Positive Control; Immunogen; SDS-PAGE; WB.
RPA667Mu02Recombinant Glucokinase (GCK)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAA667Mu01Polyclonal Antibody to Glucokinase (GCK)WB; IHC; ICC; IP.
PAA667Mu02Polyclonal Antibody to Glucokinase (GCK)WB; IHC; ICC; IP.
Assay KitsSEA667MuELISA Kit for Glucokinase (GCK)Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

ProteinsRPA667Ra01Recombinant Glucokinase (GCK)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAA667Ra01Polyclonal Antibody to Glucokinase (GCK)WB; IHC; ICC; IP.
MAA667Ra21Monoclonal Antibody to Glucokinase (GCK)WB; IHC; ICC; IP.
Assay KitsSEA667RaELISA Kit for Glucokinase (GCK)Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Human liver glucokinase gene: cloning and sequence determination of two alternatively spliced cDNAs."Proc. Natl. Acad. Sci. U.S.A. 88:7294-7297(1991) [PubMed] [Europe PMC] [Abstract]
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  6. ErratumProc. Natl. Acad. Sci. U.S.A. 89:10562-10562(1992)
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  12. "Molecular model of human beta-cell glucokinase built by analogy to the crystal structure of yeast hexokinase B."Diabetes 43:784-791(1994) [PubMed] [Europe PMC] [Abstract]
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  15. "Structural basis for regulation of human glucokinase by glucokinase regulatory protein."Biochemistry 52:6232-6239(2013) [PubMed] [Europe PMC] [Abstract]
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  20. "Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships."Proc. Natl. Acad. Sci. U.S.A. 90:1932-1936(1993) [PubMed] [Europe PMC] [Abstract]
  21. "Six mutations in the glucokinase gene identified in MODY by using a nonradioactive sensitive screening technique."Diabetes 43:730-733(1994) [PubMed] [Europe PMC] [Abstract]
  22. "Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families."Diabetologia 40:217-224(1997) [PubMed] [Europe PMC] [Abstract]
  23. "Three novel missense mutations in the glucokinase gene (G80S; E221K; G227C) in Italian subjects with maturity-onset diabetes of the young (MODY)."Hum. Mutat. 12:136-136(1998) [PubMed] [Europe PMC] [Abstract]
  24. "Mutations in the glucokinase gene of the fetus result in reduced birth weight."Nat. Genet. 19:268-270(1998) [PubMed] [Europe PMC] [Abstract]
  25. "Familial hyperinsulinism caused by an activating glucokinase mutation."N. Engl. J. Med. 338:226-230(1998) [PubMed] [Europe PMC] [Abstract]
  26. "Molecular genetics of diabetes mellitus in Chinese subjects: identification of mutations in glucokinase and hepatocyte nuclear factor-1alpha genes in patients with early-onset type 2 diabetes mellitus/MODY."Diabet. Med. 16:956-963(1999) [PubMed] [Europe PMC] [Abstract]
  27. "Identification of glucokinase mutation in subjects with post-renal transplantation diabetes mellitus."Diabetes Res. Clin. Pract. 50:169-176(2000) [PubMed] [Europe PMC] [Abstract]
  28. "Neonatal diabetes mellitus due to complete glucokinase deficiency."N. Engl. J. Med. 344:1588-1592(2001) [PubMed] [Europe PMC] [Abstract]
  29. "The previously reported T342P GCK missense variant is not a pathogenic mutation causing MODY."Diabetologia 54:2202-2205(2011) [PubMed] [Europe PMC] [Abstract]