Macrophage Migration Inhibitory Factor (MIF)

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GIF; GLIF; MMIF; Glycosylation-Inhibiting Factor; L-dopachrome isomerase; L-dopachrome tautomerase; Phenylpyruvate tautomerase

Macrophage Migration Inhibitory Factor (MIF)

One of the first cytokines described, MIF (macrophage migration inhibitory factor) was originally identified in studies of delayed hypersensitivity reactions where it was shown to inhibit macrophage migration. It is an important mediator of the innate immune response with potential roles in the pathophysiology of inflammatory, autoimmune, and neoplastic disorders. The human MIF gene encodes a 115 amino acid, 12.5 kDa secreted protein. Crystallographic studies suggest that MIF exists as a homotrimer, although some reports show that it may exist as a dimer or monomer as well. Although MIF exhibits no homology with other known cytokines, it shares structural homology with several bacterial enzymes. It has been speculated that MIF is an inflammatory mediator possibly associated with rheumatoid arthritis (RA) severity.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA698Hu01Recombinant Macrophage Migration Inhibitory Factor (MIF)SDS-PAGE; WB; ELISA; IP.
RPA698Hu02Recombinant Macrophage Migration Inhibitory Factor (MIF)SDS-PAGE; WB; ELISA; IP.
APA698Hu01Active Macrophage Migration Inhibitory Factor (MIF)Cell culture; Activity Assays; In vivo assays.
AntibodiesPAA698Hu01Polyclonal Antibody to Macrophage Migration Inhibitory Factor (MIF)WB, ICC, IHC-P, IHC-F, ELISA
MAA698Hu22Monoclonal Antibody to Macrophage Migration Inhibitory Factor (MIF)WB, ICC, IHC-P, IHC-F, ELISA
PAA698Hu02Polyclonal Antibody to Macrophage Migration Inhibitory Factor (MIF)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA698HuELISA Kit for Macrophage Migration Inhibitory Factor (MIF)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA698Mu01Recombinant Macrophage Migration Inhibitory Factor (MIF)SDS-PAGE; WB; ELISA; IP.
RPA698Mu02Recombinant Macrophage Migration Inhibitory Factor (MIF)SDS-PAGE; WB; ELISA; IP.
APA698Mu01Active Macrophage Migration Inhibitory Factor (MIF)Cell culture; Activity Assays; In vivo assays.
AntibodiesPAA698Mu01Polyclonal Antibody to Macrophage Migration Inhibitory Factor (MIF)WB, ICC, IHC-P, IHC-F, ELISA
PAA698Mu02Polyclonal Antibody to Macrophage Migration Inhibitory Factor (MIF)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA698MuELISA Kit for Macrophage Migration Inhibitory Factor (MIF)Enzyme-linked immunosorbent assay for Antigen Detection
SCA698MuCLIA Kit for Macrophage Migration Inhibitory Factor (MIF)Chemiluminescent immunoassay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA698Ra01Recombinant Macrophage Migration Inhibitory Factor (MIF)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA698Ra01Polyclonal Antibody to Macrophage Migration Inhibitory Factor (MIF)WB, ICC, IHC-P, IHC-F, ELISA
MAA698Ra21Monoclonal Antibody to Macrophage Migration Inhibitory Factor (MIF)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA698RaELISA Kit for Macrophage Migration Inhibitory Factor (MIF)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Macrophage Migration Inhibitory Factor (MIF)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Macrophage Migration Inhibitory Factor (MIF)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Macrophage Migration Inhibitory Factor (MIF)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Macrophage Migration Inhibitory Factor (MIF)CLIA Kit Customized Service Offer
n/aELISA Kit for Macrophage Migration Inhibitory Factor (MIF)ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Macrophage Migration Inhibitory Factor (MIF)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Macrophage Migration Inhibitory Factor (MIF)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Macrophage Migration Inhibitory Factor (MIF)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Macrophage Migration Inhibitory Factor (MIF)CLIA Kit Customized Service Offer
n/aELISA Kit for Macrophage Migration Inhibitory Factor (MIF)ELISA Kit Customized Service Offer

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Macrophage Migration Inhibitory Factor (MIF)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Macrophage Migration Inhibitory Factor (MIF)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Macrophage Migration Inhibitory Factor (MIF)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Macrophage Migration Inhibitory Factor (MIF)CLIA Kit Customized Service Offer
n/aELISA Kit for Macrophage Migration Inhibitory Factor (MIF)ELISA Kit Customized Service Offer
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  20. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
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  22. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
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  25. "The crystal structure of human glycosylation-inhibiting factor is a trimeric barrel with three 6-stranded beta-sheets."Proc. Natl. Acad. Sci. U.S.A. 93:3007-3010(1996) [PubMed] [Europe PMC] [Abstract]
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  27. "Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity."Biochemistry 38:7346-7354(1999) [PubMed] [Europe PMC] [Abstract]
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  29. "Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor."J. Biol. Chem. 282:23089-23095(2007) [PubMed] [Europe PMC] [Abstract]
  30. "Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions."Biochemistry 48:132-139(2009) [PubMed] [Europe PMC] [Abstract]
  31. "MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations."Proc. Natl. Acad. Sci. U.S.A. 110:10994-10999(2013) [PubMed] [Europe PMC] [Abstract]