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Desmoglein 1 (DSG1)

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CDHF4; DG1; DSG; Cadherin family member 4; Desmosomal glycoprotein 1; Pemphigus foliaceus antigen

Desmoglein 1 (DSG1)
CCC A729
HGNC 3048
MGI 94930
PubMed 12485422
UniProt Q02413
Wiki DSG1

Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus.From restriction enzyme analysis, they showed that the order of the DSG genes and their orientation is as follows: 5-prime--DSG1--DSG3--DSG2--3-prime. The desmoglein isoforms are expressed in a stratification-related manner in human epidermis, DSG1 being suprabasally expressed and DSG3 at a lower level, while DSG2 expression is weak and basal.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA729Hu01 Recombinant Desmoglein 1 (DSG1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA729Hu02 Recombinant Desmoglein 1 (DSG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA729Hu01 Polyclonal Antibody to Desmoglein 1 (DSG1) WB; IHC; ICC; IP.
MAA729Hu22 Monoclonal Antibody to Desmoglein 1 (DSG1) WB; IHC; ICC; IP.
LAA729Hu81 FITC-Linked Polyclonal Antibody to Desmoglein 1 (DSG1) WB; IHC; ICC; IF.
LAA729Hu71 Biotin-Linked Polyclonal Antibody to Desmoglein 1 (DSG1) WB; IHC; ICC.
Assay Kits SEA729Hu ELISA Kit for Desmoglein 1 (DSG1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Desmoglein 1 (DSG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Desmoglein 1 (DSG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Desmoglein 1 (DSG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Desmoglein 1 (DSG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Desmoglein 1 (DSG1) ELISA Kit Customized Service Offer
  1. "Desmosomal glycoprotein DGI, a component of intercellular desmosome junctions, is related to the cadherin family of cell adhesion molecules."Proc. Natl. Acad. Sci. U.S.A. 88:4796-4800(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Structural analysis and expression of human desmoglein: a cadherin-like component of the desmosome."J. Cell Sci. 99:809-821(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  5. "N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma."Hum. Mol. Genet. 8:971-976(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes."J. Biol. Chem. 284:31776-31788(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting." Nat. Genet. 45:1244-1248(2013) [PubMed] [Europe PMC] [Abstract]